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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

150 patients dying from renal cell carcinoma are studied in order to reveal the background disease, incidence and character of the nephrosclerosis and the possible morphogenetic link between nephrosclerosis and carcinoma. Renal cell carcinoma is found to develop in 82.7% of cases in the kidneys with signs of nephrosclerosis. The diffuse nephrosclerosis developing in connection with the hypertension disease, atherosclerosis, diabetes mellitus, chronic pyelonephritis, nephrolithiasis is the most important. Proliferation of the canaliculi epithelium with the appearance of undifferentiated cells are regularly found in the nephrosclerotic areas. The disturbance of the epithelium differentiation is followed by the development of dysplasia the phenotypical variants of which are similar to those of renal cell carcinoma. Adenomas are found in 11.3% of cases of renal cell carcinoma which may originate from the adenomas developing against the background of nephrosclerosis.
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PMID:[Background and precancerous processes in renal cell carcinoma]. 280 41

An accurate preoperative diagnosis of xanthogranulomatous pyelonephritis is difficult because of its clinical and radiological similarities to renal cell carcinoma. We report two cases of xanthogranulomatous pyelonephritis. Furthermore, in an attempt to clarify the clinical distinction between this entity and renal cell carcinoma, we summarize the clinical characteristics of 143 cases with xanthogranulomatous pyelonephritis in the literature and 126 cases with renal cell carcinoma experienced in our clinic. According to the clinical reviews, several characteristics of xanthogranulomatous pyelonephritis were revealed. 1) Presence of history of pyelonephritis. 2) gamma-globulinemia in blood chemistry. 3) Non-visualizing kidney on the excretory urogram. 4) Hypovascular or avascular features and dilatation of renal capsular arteries on angiogram. 5) Heterogenous renal mass and thickness of Gerota's fascia on computed tomogram. 6) Positive uptake of renal mass in Ga-scintigram. When some of these features are found in the renal mass, the case could be of xanthogranulomatous pyelonephritis and therefore a kidney preserving operation should be considered.
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PMID:[A clinical study of xanthogranulomatous pyelonephritis with special emphasis on the differential preoperative diagnosis between xanthogranulomatous pyelonephritis and renal cell carcinoma]. 317 36

Xanthogranulomatous pyelonephritis may, rarely, occur as a renal tumour syndrome (simulating mainly a renal cell carcinoma). We report one case. The diagnosis is often difficult (even with surgical findings) and frequently a histological surprise. This points out the importance of identifying it in preoperative staging; the diagnosis may be suggested by the association of chronic pyelonephritis, renal stones and hypovascular renal tumour syndrome without specificity at sonography and CT.
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PMID:[Pseudotumoral xanthogranulomatous pyelonephritis. Apropos of a case]. 354 Feb 92

Cytoplasmic creatine kinase (CK) activity was measured in 39 renal cortex samples from various kidney diseases. The highest CK values were observed in normal tissues (507 +/- 71). The mean values of CK enzymatic activity in the other groups decreased in the following order: chronic pyelonephritis (273 +/- 98), hydronephrosis (233 +/- 102), renal tuberculosis (133 +/- 34), pyonephrosis (96 +/- 46), and hypernephroma (45 +/- 33). The decrease in CK activity in kidney tissue paralleled tissue damage, and affects cellular functionality in relation with the processes that use adenosine 5'-triphosphate, such as the ionic pumps.
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PMID:Cytoplasmic creatine kinase in normal and pathological human kidney tissue. 358 38

A patient who presented with coexistent xanthogranulomatous pyelonephritis and renal cell carcinoma is reported. Nine previously reported cases are reviewed and the possible significance of this association is discussed.
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PMID:Coexistent xanthogranulomatous pyelonephritis and renal cell carcinoma. 360 57

Unilateral parenchymatous kidney disease associated with high blood pressure represents a potentially curable form of hypertension. Surgery may normalize blood pressure in a substantial number of these patients. Curable renal parenchymatous hypertension includes unilateral tubulointerstitial kidney diseases such as chronic pyelonephritis, reflux nephropathy, segmental hypoplasia and radiation nephritis, hydronephrosis, simple renal cysts, traumatic kidney lesions and renal tumors associated with high blood pressure. Renal ischemia and in turn activation of the renin angiotensin system is involved in the pathogenesis of hypertension in most of these patients. In patients with unilateral kidney disease and hypertension, both an operative and a medical therapeutic approach have a high success rate. Good candidates for nephrectomy are young patients with severe hypertension, strict unilateral disease, normal plasma creatinine levels and minimal function of the involved kidney. In unilateral hydronephrosis reconstructive surgery or nephrectomy may cure or improve hypertension in the vast majority of the patients. Surgically correctable hypertension has also been reported in some patients with large renal cysts and renal tumors (hemangiopericytoma, Wilm's tumor, hypernephroma, renal pelvic tumor).
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PMID:Curable renal parenchymatous hypertension: current diagnosis and management. 390 29

Our experience of finding a small renal cell carcinoma by CT suggested the diagnostic importance of CT in the early stage of the tumor. The patient was a forty-year-old woman who had suffered several times from pyelonephritis. She consulted us for detailed examination. IVP showed only slight deformity like a calyceal diverticulum at the upper pole of the left kidney. Ultrasonic tomography failed to expose the region. Enhanced CT revealed a small space occupying lesion like a simple renal cyst at the region, though plain CT revealed no abnormal findings. From the comparison of these two CT, she was diagnosed to have renal cell carcinoma which was confirmed by renal arteriography. Subsequently, transabdominal left nephrectomy was performed. Pathological diagnosis was renal cell carcinoma (clear cell type). The tumor size was very small, 1.5 cm in diameter. Comparison of plain and enhanced CT were considered important to diagnose a small tumor, and CT is now the most useful examination to detect early stage renal cell carcinoma.
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PMID:[Diagnostic importance of CT in early stage renal cell carcinoma]. 406 Dec 15

A series of 24,388 consecutive autopsies yielded 148 cases of amyloidosis, for which the associated diseases were tabulated. 13 solid primary malignancies were found in eleven patients, including one mucoepidermoid cancer of the parotid and one thymoma; two out of eleven had evidence of pyelonephritis. Five patients suffered from past or present renal adenocarcinoma, the most common carcinomatous cause of amyloidosis. Systemic amyloid deposits thus occurred in 2.1% of autopsied patients with renal carcinoma, but showed no obvious correlation with tumor stage or histologic type. Details are presented of an unusual case of hypernephroma producing a stable bronchial metastasis cuffed by nodular amyloid and dissociated by a lymphoid infiltrate containing plasma cells. The occurrence of systemic amyloidosis in non-hematologic malignancy thus appears to be a rare event, which, especially in the case of renal cancer, is assumed to be due to amyloid-fibril protein AA.
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PMID:Systemic amyloidosis and non-hematologic malignancy in a large autopsy series. 627 22

Ferritin, carcinoembryonic antigen (CEA) and beta 2-microglobulin (beta 2-MG) levels in urine from 45 patients with cancer (4 with renal adenocarcinoma, 7 with renal pelvic and ureteral cancer and 34 with bladder cancer) at various stages were clinically evaluated for their significance as parameter of urinary tract malignancies as compared to urinary fibrin/fibrinogen degradation products (FDP) and urine cytology. Ferritin levels for the poorly-differentiated and advanced stage groups were higher than those for the well-differentiated and early stage groups, and were especially high in 5 of the 7 patients with renal pelvic and ureteral cancer and all of the 7 patients with bladder cancer involving the upper urinary tract. These data suggest that determination of urinary ferritin is useful in the detection of urinary tract cancer involving the upper urinary tract. The upper limits of CEA levels were determined respectively according to white blood cell counts in urine. Although, CEA levels were elevated in the poorly-differentiated group and the advanced stage group compared to the well-differentiated and early stage groups, the values were positive in only 12 out of 52 cases (23.1%). These values seemed to be low compared to other reports. beta 2-MG levels increased significantly in the poorly-differentiated and advanced stage groups. However, most cases in the above groups were complicated with pyelonephritis or renal impairment. It is suggested that the urinary beta 2-MG secretion from cancer itself is not so significant.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Assessment of urinary ferritin, CEA and beta 2-MG determinations in patients with urinary tract malignancies]. 637 12

Two cases of xanthogranulomatous pyelonephritis (XGP) examined preoperatively by computed tomography are reported. In one, preoperative diagnosis of an inflammatory abscess-forming disease was possible. Several features of computed tomography in XGP permit differentiation from renal carcinoma. Global renal enlargement, the presence of calculi, the spread of infiltration into the fatty capsule with thickening of Gerota's fascia, and the characteristic density differences between cortex and medulla as a result of reduced contrast medium concentrations in the pyramids are suspicious of this special form of interstitial nephritis.
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PMID:Computed tomography in xanthogranulomatous pyelonephritis. 652 54


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