Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0034069 (pulmonary fibrosis)
7,050 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
collagen 1360
Mol 720
Sep 423
cytokine 386
SMA 295
smooth muscle actin 249
fibronectin 201
TNF 155
IL-6 147
tumor necrosis factor 146
Smad2 130
superoxide dismutase 115
E-cadherin 110
TGF-beta 109
Smad3 105
vimentin 102
Hermansky-Pudlak syndrome 88
type I collagen 87
IL-13 83
connective tissue growth factor 83
myeloperoxidase 82
IL-4 79
alpha-smooth muscle actin 77
transforming growth factor-beta 77
matrix metalloproteinase 76
lipopolysaccharide 73
platelet-derived growth factor 73
She 68
COPD 66
p38 66
TNF-alpha 66
chemokine 66
catenin 66
endoplasmic reticulum 64
catalase 63
ERK 63
MMP-9 62
PDGF 60
MAPK 58
lactate dehydrogenase 57
surfactant protein C 54
p53 53
GSH 52
CD4 50
IL-10 49
IFN 49
IL-17 49
MRC 48
inducible nitric oxide synthase 46
interferon 45
MMP-2 44
Mal 44
caspase-3 44
BLM 44
SARS 43
IL-1 42
EPA 42
interleukin-6 42
plasminogen activator inhibitor-1 41
lymphoid 41
tyrosine kinase 40
AKT 39
thrombin 39
PI3K 39
IL-8 38
elastin 38
glutathione peroxidase 37
BAL 36
vascular endothelial growth factor 36
mTOR 36
IFN-gamma 35
JNK 35
ERK1 35
Fas 34
Cytokine 34
metalloproteinase 34
CTGF 33
interferon-gamma 32
c-Jun 31
HPS1 31
more...
Disease
pulmonary fibrosis 7050
idiopathic pulmonary fibrosis 1193
lung disease 730
cancer 509
emphysema 377
interstitial lung disease 369
pneumonia 350
interstitial pneumonia 349
chronic obstructive pulmonary disease 341
asthma 313
pulmonary hypertension 305
PSS 301
lung cancer 296
respiratory failure 259
sarcoidosis 256
tumor 217
scleroderma 159
rheumatoid arthritis 158
silicosis 153
hypertension 143
bronchiectasis 141
cystic fibrosis 122
asbestosis 108
bronchiolitis 106
hypersensitivity pneumonitis 102
Hermansky-Pudlak syndrome 98
arthritis 91
pneumoconiosis 87
vasculitis 83
systemic lupus erythematosus 81
Raynaud's phenomenon 80
pulmonary edema 77
diabetes 76
adult respiratory distress syndrome 74
respiratory disease 70
carcinoma 66
COPD 66
tuberculosis 63
mesothelioma 62
connective tissue disease 62
heart failure 60
SARS 58
cirrhosis 57
pneumothorax 56
GSH 52
dyskeratosis congenita 51
dermatomyositis 49
colitis 48
chronic bronchitis 47
cor pulmonale 47
atherosclerosis 46
bronchopulmonary dysplasia 46
BLM 45
liver fibrosis 44
eosinophilia 44
metastases 43
virus infection 42
sepsis 42
polymyositis 40
sepsis 40
cardiovascular disease 39
autoimmune disease 39
renal failure 38
breast cancer 37
influenza 37
adenocarcinoma 36
non-small cell lung cancer 36
myositis 35
Thorax 35
infectious diseases 33
bronchitis 33
vascular disease 33
Hodgkin's disease 33
Langerhans cell histiocytosis 33
gastroesophageal reflux disease 32
bronchitis 32
sclerodactyly 31
pulmonary tuberculosis 31
aplastic anemia 31
lymphadenopathy 30
more...
Symptom
dyspnea 251
respiratory distress 166
cough 138
collapse 45
hyperoxia 42
exertional dyspnea 41
hemoptysis 39
anesthesia 38
shortness of breath 38
pain 32
fatigue 31
vomiting 26
weakness 25
diarrhea 23
nausea 20
clubbing 19
arthralgia 18
anorexia 18
chest pain 17
chronic cough 17
wheezing 16
erythema 15
nausea and vomiting 14
tachypnea 13
rales 12
headache 11
myalgia 10
cyanosis 10
chills 9
productive cough 9
cachexia 8
hypercapnia 8
hepatosplenomegaly 7
asthenia 7
Ill 7
pleuritic chest pain 6
analgesia 6
photophobia 6
tremor 6
Respiratory symptoms 6
hypocapnia 5
abdominal pain 5
discomfort 5
night sweats 5
discomfort 5
dry eye 5
thinning 5
regurgitation 4
non-productive cough 4
dysarthria 4
angina 4
seizures 4
exhaustion 4
livedo 4
dry skin 3
heartburn 3
numbness 3
abdominal discomfort 2
overweight 2
lethargy 2
bone pain 2
oliguria 2
hypoproteinemia 2
breath holding 2
starvation 2
hepatomegaly 2
low back pain 2
hoarseness 2
chest tightness 2
constipation 2
syncope 2
postnasal drip 2
fever of unknown origin 2
Physical findings 2
insomnia 2
bradykinesia 2
rhinorrhea 2
heel pain 2
vertigo 2
spasm 1
more...
Drug
Dermatol 56
MRC 48
BLM 46
Pirfenidone 43
IFN-gamma 36
Cardiovasc 32
Silica 32
lysine 26
ROS 25
CSF 19
vitamin E 18
Monit 17
Asthma 16
CTX 13
niacin 10
TiO2 10
Leaf 9
IL-2 9
uPA 7
ascorbate 7
Prednisolone 6
ETA 6
Emodin 6
Bleomycins 6
Emodin 6
Gel 6
Mutagen 5
Indomethacin 5
Vitamin E 5
ADM 5
Captopril 5
VCR 4
IL-11 4
Tacrolimus 4
Gefitinib 4
Activin 4
EE2 4
Gelatin 4
nitroglycerin 4
Itraconazole 4
SiO2 4
Paraffin 4
Sivelestat 4
Oxaliplatin 4
Prednisone 3
KGF 3
Talc 3
Fructose 3
Infliximab 3
caffeine 3
Histamine 3
Glycyrrhiza 3
CCL 3
ENT 3
Adriamycin 3
Urokinase 3
Everolimus 3
Infliximab 3
Methylprednisolone 3
citric acid 3
Gleevec 3
VCR 3
Dronedarone 2
Senicapoc 2
Heme 2
Angiotensin II 2
Artesunate 2
Dial 2
Bayer 2
Dasatinib 2
Blenoxane 2
Helium 2
Vinorelbine 2
PDGF B-chain 2
Cangrelor 2
DEX 2
Imatinib 2
Erlotinib 2
Fluorescein 2
Simvastatin 2
more...
Enzyme
mitogen-activated protein kinase 157
superoxide dismutase 136
ERK 98
peroxidase 96
catalase 64
collagenase 63
lactate dehydrogenase 61
focal adhesion kinase 55
ACE 47
protein kinase 40
luciferase 38
thrombin 37
glutathione peroxidase 37
BAL 36
urokinase-type plasminogen activator 31
reverse transcriptase 29
caspase-3 28
prolyl hydroxylase 27
elastase 24
renin 23
type III procollagen 21
protein kinase C 20
NADPH oxidase 20
MMP 19
MEK 18
NADPH oxidase 18
phosphodiesterase 16
lysyl oxidase 15
arginase 14
plasmin 14
matrix metalloproteinase 9 14
neutrophil elastase 13
trypsin 13
alkaline phosphatase 13
RNA polymerase 13
MIP 13
APC 13
proteasome 12
SPC 12
chymase 11
RNase 11
glutathione reductase 11
RNase 11
matrix metalloproteinase 2 10
caspase-1 10
ACS 10
glutathione S-transferase 10
topoisomerase 10
aspartate aminotransferase 10
lysozyme 9
NO synthase 9
caspase-9 9
topoisomerase 9
acid phosphatase 9
phosphatidylinositol 3-kinase 9
alanine aminotransferase 9
pepsin 8
chitinase 8
GSK 7
creatine kinase 7
caspase-8 7
interstitial collagenase 7
PARP 7
NQO1 7
beta-glucuronidase 6
xanthine oxidase 6
transcriptase 6
neuraminidase 6
MMP-3 6
phospholipase C 6
phospholipase A2 6
macrophage elastase 6
hyaluronidase 5
tyrosinase 5
thioredoxin reductase 5
PAH 5
tryptase 5
cathepsin D 5
phosphoinositide 3-kinase 5
NOS 5
more...
Compound
Dec 462
oxygen 445
Clin 421
BLM 296
DNA 292
TNF 155
CO2 115
water 80
Collagen 74
phosphate 72
nitric oxide 69
Paraquat 68
Paraquat 66
iron 64
calcium 63
Asbestos 56
GSH 52
GSH 52
silicon 52
proline 51
Amiodarone 49
acetate 46
sulfate 45
cysteine 41
tyrosine 38
BAL 37
His 35
sodium 35
N-acetylcysteine 34
MTT 30
Hydroxyproline 29
lysine 29
hydrogen 29
Cardiol 26
arginine 26
MDA 26
nitrogen 26
ASA 26
prostacyclin 25
PGE 24
titanium 24
creatinine 24
cobalt 24
potassium 23
BCNU 23
PGE2 23
glucose 23
ATP 22
THP 21
THP 21
guanidine 21
nickel 20
ANCA 20
Hematoxylin 19
serine 19
zinc 19
copper 18
Methotrexate 18
H2O2 17
SiO2 17
cAMP 17
urea 16
salt 15
tungsten 15
aluminum 15
Curcumin 14
Angiotensin II 14
NAD 14
dUTP 14
CTX 13
Thrombin 13
MEK 13
H2S 13
NADPH 12
Vimentin 12
NADPH 12
threonine 12
ethanol 12
Adenosine 11
leucine 11
more...