Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0034069 (
pulmonary fibrosis
)
7,050
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
C-X-C motif chemokine 17
(CXCL-17) is a novel chemokine that plays a functional role maintaining homeostasis at distinct mucosal barriers, including regulation of myeloid-cell recruitment, angiogenesis, and control of microorganisms. Particularly,
CXCL17
is produced along the epithelium of the airways both at steady state and under inflammatory conditions. While increased
CXCL17
expression is associated with disease progression in
pulmonary fibrosis
, asthma, and lung/hepatic cancer, it is thought to play a protective role in pancreatic cancer, autoimmune encephalomyelitis and viral infections. Thus, there is emerging evidence pointing to both a harmful and protective role for
CXCL17
in human health and disease, with therapeutic potential for translational applications. In this review, we provide an overview of the discovery, characteristics and functions of
CXCL17
emphasizing its clinical potential in respiratory disorders.
...
PMID:The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine. 3234 16
