Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034069 (pulmonary fibrosis)
 7,050 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Angiogenesis is a process of new blood vessels' formation occurring in many physiological and pathological conditions. Neovascularisation is the principal vascular response in chronic inflammation and concomitant fibrotic process. Microvascular changes in various organ sites in sarcoidosis (BBS) and some of the symptoms of the disease may be related to microangiopathy. Moreover, vascular alterations were also observed in lung specimens from idiopathic pulmonary fibrosis (IPF) and avian fanciers lung (AFL) patients. The present study was aimed at testing the effects of serum from 43 patients with ILD (24 BBS, 8 AFL, 8 IPF, 3 DIPF--drug induced pulmonary fibrosis) and 11 healthy controls on angiogenic capability of normal blood peripheral mononuclear cells (PBMC) in the murine intradermal angiogenesis assay (according to Sidky and Auerbach). The data demonstrated that sera from ILD patients significantly enhanced angiogenic capacity of normal PBMC as compared to control sera (p < 0.001). The effect was more pronounced for AFL patients than for BBS and IPF ones (p < 0.05). Sera from DIPF did not stimulate angiogenesis compared to control sera. The data showed that sera from ILD patients constitute sources of mediators participating in angiogenesis. This phenomenon may play role in pathogenesis of chronic immunological processes in lung.
Pneumonol Alergol Pol 1997
PMID:[Evaluation of angiogenic activity in sera from patients with interstitial lung diseases]. 976 Jul 88

Restriction is a typical functional abnormality in interstitial lung diseases (ILD) patients but not all of them represent this pattern. The aim of this study was to evaluate 164 patients with ILD in whom normal lung volumes (FVC and TLC > 80% predicted) were found. There were 111 patients with sarcoidosis (phase I--9, II--77, III--25 patients), 25 patients with pulmonary fibrosis, 12 patients with allergic alveolitis and 16 patients with disseminated radiological changes in the lungs of different etiology. Some patients (40%), mostly with fibrosis and allergic alveolitis, were treated with corticosteroids. Measured parameters included static compliance (Cst), transfer factor for CO (TLco and Kco) and maxima expiratory flow-volume curves (MEF50). 33% of patients had all examined functional parameters in normal range, 50% had decreased maximal expiratory flows (particularly in the sarcoidosis group), 46% decreased Cst and 24% decreased transfer factor. Decreased Cst was found in 31% of patients with sarcoidosis, in 67% of patients with allergic alveolitis and in 96% of patients with lung fibrosis. Decreased TLco or Kco was found only in 11% of patients with sarcoidosis, in 42% of patients with allergic alveolitis and in 60% of patients with pulmonary fibrosis. It seems that, these discussed tests are very helpful in detecting functional abnormalities in patients with ILD without signs of restriction. Increased lung elasticity and decreased transfer factor for CO indicate the existence of early or presisting functional disturbances (despite treatment) in patients with ILD and normal lung volumes.
Pneumonol Alergol Pol 1999
PMID:[Functional disturbances in patients with interstitial lung diseases without signs of restriction]. 1057 Jun 39

Conventional therapy of fibrogenic lung diseases, based mainly on the use of glucocorticoids or immunosuppressive, cytotoxic agents, does not usually protect before progression of disease and accumulation of the excess connective tissue in lungs. This article is a review of potential new therapies in the treatment of pulmonary fibrosis. Novel therapies emerged from the use of animal models of pulmonary fibrosis and recent advances in the cellular and molecular biology of inflammatory reaction involve the use of substances directed against the action of pathogenic agents: growth factors, cytokines or oxidants. Thus, future therapeutic strategies will be aimed at more selective and effective methods of controlling the key elements of pulmonary fibrosis.
Pneumonol Alergol Pol 1999
PMID:[Perspectives for treatment of pulmonary fibrosis]. 1105 10

The aim of this study was to analyze the association between HLA class I and class II DR frequency in the different stages of sarcoidosis in Polish population. 88 patients and 30 healthy controls have been typed. Patients were divided into three groups depending on radiological findings. In the first group were 28 cases presenting the regression of the disease. In the second were 33 patients in stable stage II or III and in the third group 27 patients with pulmonary fibrosis (stage IV). The typing was performed by NIH method using commercial sera. There were no statistically significant differences between studied group in HLA-A class I. The frequency of HLA B-18 was statistically more frequent in patients with sarcoidosis compared to healthy controls. HLA-DR1 was not present in third group of patients and the difference was significant compared to healthy controls.
Pneumonol Alergol Pol 2000
PMID:[Comparison of HLA class I and DR class II antigen frequency in Polish patients, in relation to different stages of the disease]. 1132 May 61

We describe a case of a 52-year old woman with clinical and immunological features of sicca syndrome associated with pulmonary fibrosis, anti-Jo-1, and anti-Ro-52 antibodies but without any signs of idiopathic inflammatory myopathy.
Pol Arch Med Wewn 2003 Dec
PMID:[Sicca syndrome and pulmonary fibrosis in a woman with anti-RO and anti-Jo-1 antibodies]. 1505 40

Histological examination was performed on 93 pulmonary nodules resected in 90 patients with known malignancy. The diameters of the coin lesions on CT scan were 3-10 mm in 42 cases and 11-30 mm in 51 cases. The most common sources of the previous malignancy were: large bowel (20), breast (14), uterus (12), kidney (11) and larynx (7). In 84 cases the nodules were radically resected through "wedge" resection and in 9 cases lobectomy was performed. Most frequently, coin lesion was caused by metastases of known malignancy (in 69.9%), pulmonary fibrosis (in 11.8%) and by primary lung cancer (in 7.5%). In general, pulmonary nodules were found malignant in 78.5% and benign in 21.5% of the cases. In the subgroup of coin lesions of diameter between 11 and 30 mm malignancy was noted in 94.1%--significantly more frequently than in subgroup of diameter between 3 and 10 mm (59.5%). No significant correlation was found between histological type of pulmonary nodules (malignant or benign) and the type of primary malignancy as well as the time from the treatment of primary malignancy to the detection of the coin lesion.
Pneumonol Alergol Pol 2003
PMID:[Coin lesion in the lung of patients with known malignancy]. 1530 57

Lung transplantation is now generally accepted as a modality of care for patients with end-stage lung diseases who demonstrate declining of lung function despite optimal therapy. This paper describe a case of single lung transplantation performed in patient with advanced obstructive pulmonary diseases and pulmonary fibrosis. One year follow-up with special regard to complications after operation is presented.
Pneumonol Alergol Pol 2004
PMID:[Single lung transplantation--one year follow-up]. 1602 99

Interstitial lung diseases (ILD) constitute a large group of disorders characterized by various etiology and pathogenesis. Inflammation and pulmonary fibrosis are the most important processes in the course of ILD. Disease causes the decrease of the gas diffusion in the lungs and provokes hypoxia. Chronic inflammation and hypoxia are strong stimulus of neovascularization. Neoangiogenesis is a principal response of vessels to inflammation. The critical importance of tumor angiogenesis in the development and metastatic spread of tumors is proved. Relations of ILD with neoplasma have been observed. Neovascularization takes an important role in wound healing allowing the cells to flow into damaged structures. Recently, pulmonary fibrosis has been deemed to result from abnormal wound healing in the lung in response to injury to the alveolar epithelium. Angiogenesis participates in pathogenesis of idiopathic pulmonary fibrosis. More and more data suggest the role of angiogenesis in pathogenesis of other ILDs, such as granulomatosis, fibrosis and vasculitis. The mechanism of angiogenesis in ILD is not clear yet. New data concerning participation of neoangiogenesis in pathogenesis of ILD created target for new drugs. Thalidomide, a strong antiangiogenic drug was used successfully in the some cases of ILD.
Pneumonol Alergol Pol 2009
PMID:[Angiogenesis in interstitial lung diseases]. 1930 10

We describe the case of a 61-year-old male patient, in which the search for the cause of chronic respiratory failure, severe pulmonary hypertension and secondary erythrocytosis resulted in a diagnosis of combined pulmonary fibrosis and emphysema (CPFE). This is a unique, recently characterised syndrome with upper-lobe emphysema and pulmonary fibrosis of the lower lungs. The cause is unknown, but one of the main risk factor remains smoking. The patient was a heavy smoker (over 40 pack-years). He complained of dyspnoea on exertion and cough. Physical examination revealed basal crackles and cyanosis. The patient had severe reduction in diffusing capacity, out of proportion to his lung volumes (DLCO 27% of predicted value, FEV1 2.95 l (100%), FVC 4.41 l (118%), FEV1/FVC (66%). The blood gas showed hypoxemia (pO2 37 mm Hg), hypocapnia and respiratory alkalosis. Diagnosis was based on chest computer tomography, which revealed upper lobe emphysema and lower lobe ground glass changes and honeycombing. Severe pulmonary hypertension (SPAP 80 mm Hg) was confirmed by echocardiography and right cardiac catherisation. The patient received long-term oxygen therapy, inhaled corticosteroid and Ca-blocker.
Pneumonol Alergol Pol 2009
PMID:[Combined pulmonary fibrosis and emphysema - case report and literature review]. 1946 58

Polymyositis (PM) and dermatomyositis (DM) are very rare connective tissue disorders which only in exceptional circumstances affect white men. The present paper describes the case of an obese 55-years-old man in whom no muscular-skeletal system symptoms were found during the period of 2 years before the onset of arthritis, and who was treated because of cardiac involvement (pericarditis, PAF), pleuritis, malaise and fever. Only the occurrence of non erosive arthritis decided on the connective tissue disorder as a cause of his complaints. Previously the diagnostics was based on the exclusion of malignant diseases and bacterial and viral infections. The determination of antinuclear antibodies in high titer without any specific, typical of individual disease entities antinuclear antibodies allowed only the diagnose of undifferentiated connective tissue disease. Glucocorticosteroid treatment was initiated, however six months later despite treatment with metyloprednisolone the symptoms and signs associated with PM accompanied by high level of creatinophosphokinase and elevated transaminase were found. The muscle biopsy revealed myositis, but no specific antibodies, especially anti-Jo-1, were detected. It is very interesting that cyclophosphamide + glucocorticoids pulse therapy failed to prevent the development of antiphospholipide syndrome and interstitial pulmonary fibrosis in the PM patient. Overlapping of immunological tissue disorders is a well-known phenomenon, but in the case of fulminating and distinct symptoms and signs the lack of detection of specific antibodies is quite uncommon.
Pol Arch Med Wewn 2008
PMID:Symptoms and signs of polymositis, systematic lupus erythematosus and antiphospholipid syndrome follow consecutively 1956 77


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