Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034069 (pulmonary fibrosis)
 7,050 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Morphological analysis of lungs was carried out in patients dying in the Department of Neurology who were treated before death by controlled respiration with respirators. Changes in the pulmonary tissue included mainly atelectasis and chronic oedema. For a better analysis the material was divided into 4 groups. Group I included earliest changes with slight atelectasis and hyperaemia of alveolar septa. Group II comprised cased with advanced atelectasis and manifest oedema. Group III contained cases with hyaeline membrane presence. In group IV pulmonary fibrosis was found. These findings were similar to those observed in other patients treated with respirators.
Neurol Neurochir Pol
PMID:[Morphological changes in lung tissue developing during controlled respiration in patients with severe neurological diseases]. 105 47

Long-term oxygen therapy (LTOT) became a routine in the treatment of severe respiratory failure and cor pulmonale. Four years experience of the LTOT in Warsaw is presented. From 237 patients referred 172 were qualified for treatment. Majority--130 (76%) suffered from COPD. The rest of the group presented with pulmonary fibrosis, tb sequelae, bronchiectasis, kyphoscoliosis or chronic pulmonary thromboembolic disease. The mean oxygen breathing time averaged 14.5 H/day. Seventy two patients that is 42% of treated group died. The most frequent (63%) cause of death was respiratory failure. No adverse effects of LTOT were observed.
Pneumonol Alergol Pol 1992
PMID:[4-year experience of the Warsaw Center for Home Oxygen Therapy]. 129 25

Clinical symptoms and signs and the frequency of abnormalities in the results of enzymatic, electromyographic, histological and serological tests were analysed in 50 patients, including 17 with polymyositis (PM) and 33 with dermatomyositis (DM), groups I and II according to Bohan's classification and followed-up for 25 years. Weakness of the proximal muscles of the extremities was present in both groups in all patients and in a high proportion of cases weakness involved also the distal muscles. Dysphagia was more frequent in DM patients (54.5%) than in PM (17.6%). In DM erythema and facial oedema as well as Gottron's sign were observed more frequently. In 11.8% of PM patients and 15.1% of DM patients deposition of calcium salts in subcutaneous tissue developed. Signs of vasculitis were found in 39.4% of DM cases and 17.6% of PM cases. In one-third of PM and in only 3 DM cases pitting oedema of the distal parts of the extremities was noted. Cardiovascular changes were disclosed in 82.3% of PM and 69.7% of DM patients. On the other hand, radiological signs of interstitial pulmonary fibrosis were noted more frequently in DM (36%) than in PM (23%). Increased serum activity of CPK, AspAT and ALAT was present with similar frequency in both groups from 71% to 81% of cases. EMG showed evidence of primary muscular changes in all PM patients and 69.6% of DM patients. Histological examination confirmed the diagnosis in the studied patients. Antinuclear antibodies were found relatively rarely, from 2% to 24% of PM/DM patients.(ABSTRACT TRUNCATED AT 250 WORDS)
Mater Med Pol
PMID:Polymyositis-dermatomyositis--a 25-year follow-up of 50 patients (analysis of clinical symptoms and signs and results of laboratory tests). 213 28

The determination of total hydroxyproline (Hyp) with separation into protein and non-protein fractions was carried out in 24-hour urine samples of healthy persons, patients with sarcoidosis and patients with interstitial pulmonary fibrosis (i.p.f.). In the group of sarcoidosis Hyp excretion was evaluated taking into account progression of pulmonary changes and disease activity. It was found that total and non-protein Hyp excretion correlated positively in healthy persons as well as in those with sarcoidosis, and interstitial pulmonary fibrosis. An increased excretion of total and non-protein Hyp occurred in 24% of the patients with sarcoidosis while excretion of protein Hyp remained within the normal range. In 30% of the patients with interstitial pulmonary fibrosis increased excretion of total and non-protein Hyp was demonstrated. The excretion of protein Hyp in these patients did not deviate from normal values. The results of our study indicate that determination of total and nonprotein Hyp in urine may be useful in the evaluation of fibrotic changes in the pulmonary diseases mentioned above. However, these parameters are not usefull in differentiation between sarcoidosis and interstitial pulmonary fibrosis.
Mater Med Pol
PMID:Urinary excretion of protein and non-protein hydroxyproline in patients with sarcoidosis and interstitial pulmonary fibrosis. 841 35

Sialic acid is a component of cell membranes and it can take part in immunological processes with lymphocytes and neutrophiles. In the present work the concentration of sialic acid in BALF in selected interstitial pulmonary disease was studied (in sarcoidosis, pulmonary fibrosis, avian fanciers lung) and compared with the control group of healthy persons. The investigations were repeated during the observations. The patients were divided into active and inactive groups. The analysis included the results in 187 patients divided into 9 groups. Sialic acid was measured with colorimetric method with the use of Ehrlich's reagent. The growth of sialic acid concentration in supernatant of BALF was observed in the studied diseases. The increase of sialic acid occurs in inflammatory processes especially those with neutrophiles. The correlation of acid concentration with the percentage or the total number of lymphocytes in BALF was observed. It is specific that the concentration of sialic acid in BALF in patients with avian fanciers lung keeps growing even after the contact with the antigen was discontinued.
Pneumonol Alergol Pol 1995
PMID:[Concentration of sialic acid in bronchoalveolar lavage fluid in selected interstitial pulmonary diseases]. 861 78

Bleomycin induces local inflammatory process with subsequent pulmonary fibrosis. An unknown chemoattractant induces the mast cell (MC) migration to the injured lung tissue. Aim of this study was evaluation of the number, topography and ultrastructure (TEM) of the MC in rat lungs with bleomycin-induced fibrosis. The bleomycin was administered once intratracheally (3.6 mg/kg). The animals were sacrificed on 7th. 14th and 21st day of experiment. MC were stained with Csaba's method. An evident increase in MC number related to the phase of experiment and stage of lung fibrosis was observed: 520, 1200, 4745 per cm2 section on the 7th, 14th and 21st day respectively. In control the MC number was 163 per cm2 section (p < 0.001). On the 7th day the MC were rich in red granules (mature granules with preponderance of heparin). They were located mainly in pleura and around the blood vessels, as in control. On the 14th and 21st day the majority of MC was situated in places of active fibrosing. They contained exclusively blue granules (the young granules with preponderance of biogenic amines), mixture of increased secretory function of the MC in the fibrotic lungs. Some of the MC granules showed fusion and altered matrix contents, other were emptied in piecemeal manner. A net of microtubules connected the granules was observed. Degranulation of MC may release heparin and cytokines able to stimulate synthesis of extracellular matrix. It has been suggested that heparin contributes to the fibrotic process and angiogenesis, stimulating directly or indirectly collagen synthesis by binding, stabilization and activation of fibroblast growth factor (FGF) and cell adhesion glycoproteins.
Pneumonol Alergol Pol 1995
PMID:[Morphology of mast cells in experimental pulmonary fibrosis induced with bleomysin]. 864 Jan 54

Between August 1986-July 1994 45 1 patients with chronic hypoxaemia were referred to us for evaluation. 315 of them (70%) were qualified for LTOT according to national guidelines. There were 189 pts with COPD (60%), 40 with late sequelae of pulmonary tuberculosis (TB), 21 with interstitial pulmonary fibrosis (IPF), 15 with bronchiectasis (BE), 15 with severe kyphoscoliosis (KS) and 35 with other disease leading to chronic respiratory failure. All patients received oxygen from an oxygen concentrator and have been regularly followed-up. The best survival rate in patients followed up for at least 3 years was observed in KS (68%) and COPD pts (50%). The worst survival was seen in BE (9%) and IPF (21%). 183 pts died during the follow-up and in 3 pts (1%) LTOT was withdrawn. The most frequent cause of death were either acute (58%) or chronic (21%) cardiorespiratory failure.
Pneumonol Alergol Pol 1996
PMID:[Eight years of experience in Warsaw with domiciliary long term oxygen therapy]. 899 52

The course of the pulmonary fibrosis is difficult to estimate as there are no diagnostic tests specific and sensitive enough to assess disease activity. Together 33 patients with pulmonary fibrosis have been studied. They have been divided into 2 subgroups, depending on the intensity of clinical, radiologic, and functional disorders. In all patients bronchoalveolar lavage has been carried out, and the obtained results have been compared with those in 18 healthy individuals. Changes in the cellular composition of BAL fluid had polymorphic character. In the early phase of the disease, only percentage of lymphocytes in BAL fluid has been increased significantly whereas in the more advanced stage percentage of both neutrophils and eosinophils has also been significantly increased. The use of several parameters simultaneously helps to evaluate pulmonary fibrosis.
Pol Merkur Lekarski 1996 Jul
PMID:[Clinical, radiologic and functional changes in the respiratory system and changes in cytology of bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis]. 915 84

For the first time in Poland we present the case of pulmonary reaction to furazidin which is by chemical structure closely related to nitrofurantoin. 63 years old woman presented generalized symptoms of acute hypersensitivity reaction induced by furazidin as well as features of chronic pulmonary fibrosis. After few months of treatment with this drug patients complained of weight loss, dyspnea on effort, non-productive cough, chills and fever. Radiological and functional evaluation of respiratory system confirmed features of lung fibrosis. Drug provocation test was positive. In vitro furazidin in low concentrations stimulated proliferation of patient's lymphocytes. After cessation of treatment we have observed rapid improvement of clinical, radiological, biochemical and functional parameters.
Pol Arch Med Wewn 1997 May
PMID:[Pulmonary reaction after furazidin (Furagin). Case report]. 941 25

Asbestos exposure results in an increased risk of nonmalignant as well as of malignant pulmonary and pleural disease. The asbestos-related disease are inexorably progressive (cancer) or insidious (fibrosis), untreatable and widespread in the industrialized and urban world. The identification of these diseases is important because therapy and prognosis differ from the other pulmonary fibrosis. The case reports indicate that careful clinical and histologic examination allows proper diagnosis. Two patients with asbestos-related disease after asbestos exposure are described.
Pneumonol Alergol Pol 1997
PMID:[Lung and pleural changes caused by exposure to asbestos]. 948 44


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