Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034069 (pulmonary fibrosis)
 7,050 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 26 subjects with a confirmed histological diagnosis of thoracic sarcoidosis regional lung function was studied with Xenon 133. All subjects also underwent overall lung function studies including CO steady state (TCO SS) and single breath (TCO SB) diffusing capacity. Regional ventilation (Vr) was on the average increased in stages I (isolated hilar adenopathies) and II (pulmonary infiltration) and appeared normal in stage III (pulmonary fibrosis). Regional perfusion (Qr) was on the average normal in stages I and II and decreased in stage III. There were no appreciable differences between average values in stages I and II. Abnormalities of Vr and Qr were frequently found in individual cases. A distinction was made between the total number of abnormalities and deficiency abnormalities. The total number of abnormalties was high in all three stages. Deficiency abnormalities were relatively rare in stages I and II, and frequent in stage III. The correlation between radiological and regional functional abnormalities was low. TCO SB/VA was found significantly lower (P less than 0.005) in subjects with regional deficiency abnormalities (mostly perfusion abnormalities). These data probably indicate that a lowered diffusing capacity may be due to the loss of pulmonary capillaries and not only to ventilation - perfusion disparities.
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PMID:Regional pulmonary function in sarcoidosis. 84 Dec 91

Fifty patients with ankylosing spondylitis underwent radiography of the chest. In addition, 2 of them had bronchography, 3 had computerized tomography (CT) of the chest, 9 had respiratory function tests and 8 head ventilation/perfusion study by the Xenon method. Seven thoracic images were questionably specific of spondylitis, showing plural symphysis, strips of atelectasis, pleural thickening, apical pulmonary sclerosis and opacities of the diaphragmatic hilum. CT proved valuable in 1 case to confirm pulmonary fibrosis and in 2 cases to reveal that pleural thickening was continuous with an opacity ensheathing the vertebral body. In 7 out of 9 cases the functional restrictive deficit was accompanied by normal or supranormal functional residual capacity and increased residual volume. In all patients explored by the Xenon method, there was apical-caudal inversion of the ventilation/perfusion ratio. These findings suggest 3 pathogenic hypotheses: mere sequelae of hypoventilation, specific lung tissue fibrosis, extension by continuity of the vertebra-ensheathing process to the subpleural spaces.
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PMID:[Respiratory manifestations of ankylosing spondylitis (50 cases)]. 358 43