Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0034069 (
pulmonary fibrosis
)
7,050
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Donor-acquired solid organ malignancy is a rare complication of organ transplantation. We report a case of a patient who received bilateral lung transplants for
pulmonary fibrosis
from a donor with known
glioblastoma multiforme
(
GBM
). The lungs, heart, liver, and kidneys were harvested after a lethal intracranial bleed and accepted for transplantation by four centers. An enlarged hilar lymph node sampled at the time of transplant was found to contain
GBM
. Four months later, the patient developed diffuse interstitial pulmonary infiltrates with mediastinal lymphadenopathy. Lung biopsy confirmed metastatic
GBM
. The patient died 2 weeks after the diagnosis was established. The patient receiving the donor liver also developed
GBM
. We present a case study, review of the literature, and suggested interventions to minimize the risk of transmission.
...
PMID:Transmission of glioblastoma multiforme following bilateral lung transplantation from an affected donor: case study and review of the literature. 1527 19
