Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034069 (pulmonary fibrosis)
 7,050 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We studied one hundred consecutive patients with rheumatoid arthritis from the cardiological point of view through non invasive methods to detect the frequency of cardiovascular complications. Seventy three (73%) were females and twenty seven (27%) males. Mean age, 48.6 years. Mean age of presentation of the disease, 34.2 years. Mean age of duration of the illness, 21.8 years. Fifty seven per cent had some type of cardiopulmonary complication. Clinically 52 per cent referred some type of cardiopulmonary symptoms. The physical examination was abnormal in 27 per cent. Rheumatoid factor (Waaler-Rose) was positive in 82 per cent. The cardiac X ray series was abnormal in 33 per cent, the resting electrocardiogram in 48 per cent and the M mode echocardiogram in 52 per cent of the cases. The complications detected were: pericardial effusion (21%); pleural effusion (9%); pulmonary fibrosis (6%) which represents a higher incidence of previously reported in the literature; congestive heart failure (10%); valvular lesion (9%) among those are included six patients with valvular heart disease of non detectable etiology; ischemic heart disease (8%); myocarditis (6%); rythm disturbances (22%) and conduction defects (20%) including a 46 year old female patient who developed a complete AV block during an exacerbation of her illness, requiring the insertion of definitive pacemaker. Our results showed that some of the detected lesions are in part more frequent and severe than those reported in the literature, probably due to, that on one hand their search was intentional and on the other, our group was constituted by with severe and long standing rheumatoid arthritis.
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PMID:[The heart and rheumatoid arthritis. Prospective study of 100 cases]. 295 63

We report on four members of a family with rheumatic diseases. Rheumatoid arthritis of an extremely severe and mutilating type developed in a 17-year-old boy (Patient 1). The disease showed some characteristics of juvenile chronic arthritis. 20 years later his sister (Patient 2) was affected by progressive systemic sclerosis (PSS) with arthritis, Raynaud's phenomenon, aperistalsis of the esophagus and pulmonary fibrosis, however without skin involvement. After 2 years rheumatoid arthritis developed in the mother of the family (Patient 3) and another 2 years later the second son (Patient 4) was affected by mixed connective tissue disease (MCTD) with arthritis, Raynaud's phenomenon, aperistalsis of the esophagus and a high titer of antibody to extractable nuclear antigen (ENA). Rheumatoid factor was found in Patient 1, 2 and 3. All members of the family expressed HLA-DR3 in association with HLA-B8. Earlier reports in the medical literature of the familial occurrence of rheumatoid arthritis, progressive systemic sclerosis, systemic lupus erythematosus and other collagen diseases, e.g. mixed connective tissue disease, are reviewed, with a discussion of the possible etiologic mechanisms.
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PMID:[Rheumatoid arthritis, progressive systemic sclerosis without skin involvement and mixed collagen disease in a family. Clinical description of a mother and her 3 adult children--studies of HLA antigens and review of the literature]. 370 74