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Query: UMLS:C0034069 (pulmonary fibrosis)
 7,050 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The fungus Aspergillus can cause a variety of pulmonary disorders. Allergic bronchopulmonary aspergillosis is characterized by eosinophilic pulmonary infiltrates, bronchiectasis and bronchial mucus plugs, and can progress to chronic pulmonary fibrosis. There are four additional variant forms of allergic bronchopulmonary aspergillosis, which may or may not be associated with aspergillus hypersensitivity. They are mucoid impaction of bronchi, pulmonary infiltrates with eosinophilia, bronchocentric granulomatosis, and extrinsic allergic alveolitis. Intracavitary aspergilloma (mycetoma, or fungus ball) is a noninvasive Aspergillus colonization of virtually any type of preexisting pulmonary cavity or cystic space. Invasive pulmonary aspergillosis is a serious, usually fatal infection in patients being treated with immunosuppressions or who have chronic (malignant or nonmalignant) debilitating disease. Diagnosis of Aspergillus-caused pulmonary disorders is based on a combination of clinical, laboratory, and radiographic findings, all of which should be known to the radiologist.
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PMID:Thoracic manifestations of aspergillosis. 676 22

To describe the association between invasive pulmonary aspergillosis and steroid treatment in patients with no immunodepression attributable to other causes. We reviewed the case histories of apparently non immunodepressed patients in our hospital with histological diagnoses of invasive pulmonary aspergillosis between 1992 through 1996. Seven patients were identified. Laboratory, clinical and radiological data were collected, as well as type and duration of steroid treatment. Four patients suffered underlying chronic obstructive pulmonary disease, 1 had temporal arteritis, 1 interstitial pulmonary fibrosis and 1 a neurological tumor. All had received steroid treatment for periods varying from several days to 16 months, at varying doses, although the majority of them were treated with 1mg/kg/day. All presented clinical profiles suggestive of pneumonia (5 community acquired and 2 nosocomial). Invasive pulmonary aspergillosis can appear in minimally immunocompromised patients, such as those undergoing steroid treatment and must be suspected whenever pneumonia is seen in patients receiving steroids who do not improve with widespectrum antibiotic treatment.
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PMID:[Steroid treatment: risk factor for invasive pulmonary aspergillosis]. 961 41