Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034069 (pulmonary fibrosis)
 7,050 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The bronchiolo-alveolar adenocarcinoma, less frequent than other types of bronchopulmonary cancers, occurs more frequently during pulmonary fibrosis. Besides a mucous bronchorrhea of little meaning, the clinical manifestations belong to the advanced stages. The X-ray, unreliable and variable, shows a variety of pictures from mono or multinodular ones to pseudopneumonic infiltrates. Usually no information could be derived from bronchoscopy. Positive cytological examination of sputum are unfrequent. Early surgery brings longer remissions than in other types of bronchopulmonary cancer. Diagnosis can only be made from the histology of the exeresis sample. The tumour cells, cuboidal or columnar, are arranged in mono or pluri-stratified layers in the inter-alveolar septa, which progressively become fibrous. This cancer has an original histogenesis: it would originate from the neoplastic metaplasia of type II pneumocytes or of respiratory bronchiole cells, invading the pulmonary alveoli by sliding or by contiguity. Far from the initial foyer, the spreading seems mostly done through airways.
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PMID:[Bronchiolo-alveolar cancer]. 18 6

Three patients with chronic respiratory failure of various etiology, who have (had) been in the hospital for some years, were presented. The case 1 is male and was 57 years old on admission. He has been suffered from right thoracic emphysema from October '83, which is under chronic infection of Pseudomonas aeruginosa, with bronchial fistula and aortic valve insufficiency. His pulmonary function is severely restrictive and the grade of his dyspnea has been V of Hugh-Jone's criteria and he is now unable to leave from bed. The case 2 is male and was 41 y.o. on admission. He has been ill with diffuse cystic bronchiectasis from 33 y.o. and bronchorrhea (greater than 200 ml/day) with chronic infection of Pseudomonas aeruginosa has been lasting and recurrent attacks of infection have progressively worsened of his pulmonary and cardiac functions. He is now indispensable to assist ventilation by artificial respirator every 2-3 days. The case 3 was male and 27 y.o. on admission. He had admitted because of severe dyspnea due to familial pulmonary fibrosis on August '86. His disorder had been progressive and resistant against repeated corticosteroid therapy. He died of respiratory failure at 30 years old. The transplantations of lung and heart-lung for critical patients with respiratory failure have been challenged in North America and Europe, but in Japan, many social and medical problems about transplantation have yet been unresolved. The indications for and against lung or heart-lung transplantation to these three patients was discussed with reference to English literatures.
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PMID:[Three cases of chronic respiratory failure]. 262 Jan 34