Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0034069 (pulmonary fibrosis)
 7,050 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of lethal midline granuloma is reported, which resulted from immunosuppressive therapy with corticoids over months because of pulmonary fibrosis. An autoimmune disease according to a cell mediated immune reaction (type IV--classification of Coombs and Gell) is discussed. Wegener's granulomatosis and a T-cell lymphoma were excluded. Continuation of this lymphoproliferative disease would eventually have resulted in a T-cell lymphoma.
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PMID:[Lethal midline granuloma as a result of months-long immunosuppressive therapy. A case report]. 228 31

NK-631 (Peplomycin) has an anti-tumor spectrum, equivalent to or higher than its analogue bleomycin and low toxicities to the lungs. Fourteen patients with advanced non-Hodgkin's lymphoma received NK-631 10 to 30 mg once or twice a week. As the results, there were 57.1% response rate of all patients. The response rate according to the immunologic classification were 100%(6/6 cases) for patients with non-T cell lymphoma and 25%(2/8 cases) for patients with T-cell lymphoma. On the other hand, we observed some toxicities such as transient fever in 64.3%, G-I tract symptoms in 21.4%, skin toxicities in 21.4% and pulmonary fibrosis in one case. This agent is considered to be one of the useful agents to non-Hodgkin's lymphoma especially non-T cell lymphoma.
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PMID:[Treatment of non-Hodgkin's lymphoma with NK-631 (peplomycin)--with special reference to the effect on T and non-T cell lymphomas]. 619 97