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Query: UMLS:C0034069 (pulmonary fibrosis)
 7,050 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The fungus Aspergillus can cause a variety of pulmonary disorders. Allergic bronchopulmonary aspergillosis is characterized by eosinophilic pulmonary infiltrates, bronchiectasis and bronchial mucus plugs, and can progress to chronic pulmonary fibrosis. There are four additional variant forms of allergic bronchopulmonary aspergillosis, which may or may not be associated with aspergillus hypersensitivity. They are mucoid impaction of bronchi, pulmonary infiltrates with eosinophilia, bronchocentric granulomatosis, and extrinsic allergic alveolitis. Intracavitary aspergilloma (mycetoma, or fungus ball) is a noninvasive Aspergillus colonization of virtually any type of preexisting pulmonary cavity or cystic space. Invasive pulmonary aspergillosis is a serious, usually fatal infection in patients being treated with immunosuppressions or who have chronic (malignant or nonmalignant) debilitating disease. Diagnosis of Aspergillus-caused pulmonary disorders is based on a combination of clinical, laboratory, and radiographic findings, all of which should be known to the radiologist.
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PMID:Thoracic manifestations of aspergillosis. 676 22

Sarcoidosis has innumerable clinical manifestations, as the disease may affect every body organ. Furthermore, the severity of sarcoidosis involvement may range from an asymptomatic state to a life-threatening condition. This manuscript reviews a wide variety of common and less common clinical characteristics of sarcoidosis. These manifestations are presented organ by organ, although additional sections describe systemic and multiorgan presentations of sarcoidosis. The lung is the organ most commonly involved with sarcoidosis with at least 90 % of sarcoidosis patients demonstrating lung involvement in most series. The skin, eye, liver, and peripheral lymph node are the next most commonly clinically involved organs in most series, with the frequency of involvement ranging from 10 to 30 %. The actual frequency of sarcoidosis organ involvement is probably much higher as it is frequently asymptomatic and may avoid detection. This is particularly common with lung, liver, cardiac, and bone involvement. Cardiac sarcoidosis is present in 25 % of all sarcoidosis but only causes clinical problems in 5 % of them. Nevertheless, unlike sarcoidosis involvement of most other organs, it may be suddenly fatal. Therefore, it is important to screen for cardiac sarcoidosis in all sarcoidosis patients. All sarcoidosis patients should also be screened for eye involvement as asymptomatic patients may have eye involvement that may cause permanent vision impairment. Pulmonary fibrosis from sarcoidosis is usually slowly progressive but may be life-threatening because of the development of respiratory failure, pulmonary hypertension, or hemoptysis related to a mycetoma or bronchiectasis. Some manifestations of sarcoidosis are not organ-specific and probably are the result of a release of mediators from the sarcoid granuloma. Two such manifestations include small fiber neuropathy and fatigue syndromes, and they are observed in a large percentage of patients.
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PMID:The Clinical Features of Sarcoidosis: A Comprehensive Review. 2527 50