Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0034067 (emphysema)
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Human Gene/Protein
elastase 2B 11.4
IREB2 protein 11.4
ANKRD18A 10.4
Alpha-1 antitrypsin 10.3
alpha-1 globin 10.1
LTA4H protein 9.8
MFAP3 9.8
ZNHIT6 9.8
TACC2 protein 9.8
MME protein 9.8
Metalloelastase 9.6
COBP 9.6
p0071 protein 9.4
metalloelastase 9.0
Alpha-1-antitrypsin 9.0
Zinc finger E-box binding homeobox 2 8.8
ARHGAP28 8.8
ARCP 8.8
matrix metalloproteinase 12 8.8
MMP12 8.7
FBLN5 8.6
alpha-1 antitrypsin 8.5
RAG1 mRNA 8.4
CCDC103 8.4
ASRGL1 8.4
FBLN4 8.3
SERPINE2 8.3
FAM13A 8.3
GPR116 8.3
NADPH oxidase organizer 1 8.3
retinoic acid early transcript 1 8.3
CALM/AF10 fusion 8.3
MMP-12 8.1
ARCL 8.1
PS21 8.1
neutrophil elastase 8.0
MFAP1 8.0
UBCH7 8.0
LPHN2 8.0
anti-elastase 8.0
LTBP-4 7.9
elastase inhibitor 7.9
alpha 1-antitrypsin 7.9
CTDP1 7.8
NPNT 7.8
RAB4B 7.8
bomapin 7.8
SVIP 7.8
DANCE 7.8
alpha-1-antitrypsin 7.8
Surfactant protein D 7.7
COPD 7.7
AAT 7.7
PCBP3 7.6
ROR gamma 7.6
IL13RA1 7.5
Pancreatic elastase 7.5
MFAP5 7.5
ORC6 7.5
NINJ2 7.4
Apoptosis inhibitor 7.3
x25 7.3
Histone deacetylase 2 7.3
BICD1 7.3
fibulin-4 7.3
FEV 7.3
ABHD2 7.3
Retinol dehydrogenase 12 7.3
V75 7.2
HDAC2 protein 7.1
NPT2 7.1
CHRNA 7.1
ORC4 7.1
HHIP 7.0
Tissue inhibitor of metalloproteinase 1 7.0
CL-6 7.0
elastin precursor 7.0
FNIP2 7.0
HS6ST2 7.0
MFAP4 7.0
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Disease
asthma, exogenous 11.4
Instantaneous clearance 11.4
Esophageal tear 11.4
emphysema 11.4
Linear atelectasis 11.4
Orbital emphysema 11.3
Giant bullous emphysema 11.1
Paraseptal emphysema 11.1
Centrilobular emphysema 11.1
Panlobular emphysema 11.0
Vanishing lung 10.9
Tracheal perforation 10.8
Bronchiolectasis 10.8
Bullous emphysema 10.7
Interstitial pulmonary emphysema 10.4
Pulmonary pneumatocele 10.4
Tracheal rupture 10.2
Chronic pulmonary histoplasmosis 10.1
Chronic obstructive bronchitis 10.1
Respiratory bronchiolitis-associated interstitial lung disease 10.0
AAT deficiency 9.9
smokers lung 9.8
Gas bubble disease 9.8
Old tuberculosis 9.8
Pharyngeal perforation 9.8
Bronchocutaneous fistula 9.8
Plate-like atelectasis 9.8
Factitious lymphedema 9.8
Interstitial emphysema 9.8
Emphysematous gastritis 9.8
small airways disease 9.5
Traumatic reticuloperitonitis 9.4
Obstructive bronchitis 9.4
Diffuse pulmonary fibrosis 9.4
Chronic respiratory failure 9.4
Clinical pneumonia 9.4
Open pneumothorax 9.4
Bullous lung disease 9.4
pneumopericardium 9.4
Chronic Airflow Obstruction 9.3
Chronic mucus hypersecretion 9.3
Acute exacerbation of chronic bronchitis 9.1
Gastric erosion 9.1
Generalized atherosclerosis 9.1
Periapical abscesses 9.1
FENIB 9.1
Obstructive emphysema 9.1
chronic bronchitis 8.9
Pulmonary Disorder 8.8
Bronchial infection 8.8
Acute anaphylaxis 8.8
Traction bronchiectasis 8.8
Severe chronic obstructive pulmonary disease 8.8
Congenital cutis laxa 8.7
uremic pneumonitis 8.6
Chronic lower respiratory diseases 8.6
sinus problem 8.6
Boerhaave's syndrome 8.5
vertiginous syndrome 8.4
Postoperative atelectasis 8.4
Laryngeal papilloma 8.4
tension pneumothorax 8.4
chronic bronchiolitis 8.3
14q deletion syndrome 8.3
congestive atelectasis 8.3
Moderate depression 8.3
Type III reaction 8.3
Secondary tuberculosis 8.3
pneumothorax 8.3
Hypocomplementemic urticarial vasculitis 8.2
Auto-PEEP 8.2
anthracosis 8.1
unable to stop smoking 8.1
CLE 8.1
Elastolysis 8.0
Acquired cutis laxa 8.0
Chronic rheumatic heart disease 8.0
Biventricular hypertrophy 8.0
Esophageal rupture 8.0
Rectal perforation 7.8
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Symptom
Bronchial breathing 9.4
Blotchy 9.0
Lung hyperinflation 8.9
Air trapping 8.8
Rhonchi 8.4
feeling of choking 8.1
Lung hernia 7.7
swollen scrotum 7.4
Diaphragmatic weakness 7.2
Thoracic pain 7.1
Hoover's sign 6.9
Portal venous gas 6.8
vasovagal attacks 6.8
dyspnea 6.2
labored breathing 6.0
productive cough 5.8
respiratory distress 5.8
shortness of breath 5.7
Platypnea 5.7
nocturnal cough 5.6
hemoptysis 5.6
exertional dyspnea 5.6
retching 5.5
itchy nose 5.5
wheezing 5.5
Respiratory symptoms 5.4
chest tightness 5.3
chronic cough 5.3
rales 5.3
diastolic murmurs 5.2
pleuritic chest pain 5.2
clubbing 5.2
stridor 5.2
hypercapnia 5.2
cyanosis 5.1
aphonia 5.1
sneezing 5.1
prominent nose 5.1
frequent urination 5.0
hoarseness 5.0
cough 5.0
tachypnea 4.9
non-productive cough 4.9
catarrh 4.8
sighing 4.8
persistent cough 4.8
Nasal symptoms 4.7
abnormal breathing 4.7
cardiovascular impairment 4.7
monoplegia 4.7
Physical findings 4.6
chest pain 4.6
Exercise intolerance 4.6
bigeminal 4.4
sore throat 4.4
photopsia 4.4
Postoperative nausea and vomiting 4.4
thigh pain 4.4
pneumaturia 4.3
neck pain 4.3
breath holding 4.3
voice change 4.2
iliac fossa pain 4.1
Regurgitation 3.9
eye pain 3.9
nasal discharge 3.8
collapse 3.8
bradypnea 3.8
Opposition 3.8
emaciation 3.7
epigastric pain 3.7
inanition 3.6
orthopnea 3.6
hyperoxia 3.5
hyperemesis gravidarum 3.3
vomiting 3.2
thirsty 3.1
otalgia 3.1
drooling 3.0
testicular pain 3.0
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Drug
Colfosceril palmitate 11.4
Prolastin 9.8
Dried yeast 9.4
Seratrodast 8.1
Ferric oxide 7.4
Citrus unshiu peel 7.3
Spiriva 7.3
Terbutaline sulfate 7.2
Frova 7.0
Oxybuprocaine 6.8
Arachidonic Acid 6.8
Bisolvon 6.7
Survanta 6.5
Panipenem 6.4
Cilomilast 6.0
Talc 6.0
Atrovent 5.8
Berotec 5.8
Ipratropium bromide 5.7
Frovatriptan 5.7
Papain 5.6
TPV 5.6
PAPM/BP 5.5
Cordarone 5.5
Lasalocid 5.5
ATV 5.5
Roflumilast 5.4
Roflumilast 5.4
Cordarone 5.3
Pimobendan 5.3
Buscopan 5.2
Pirfenidone 5.1
Bricanyl 5.1
Ceftibuten 5.1
Sodium hypochlorite 5.0
Domin 5.0
Polydioxanone 4.9
SF6 4.7
Ritalin 4.6
CA-074 4.6
Trapidil 4.6
Helium 4.5
CDX 4.4
DPE 4.3
Molsidomine 4.2
FLM 4.2
CPZ 4.1
Beta-2 4.1
CDX 4.0
SBT 3.8
Rolipram 3.7
Amrinone 3.6
Fenoterol 3.5
Magnevist 3.5
MRC 3.5
PFT 3.5
Iopamidol 3.5
Theophylline 3.5
Sinemet 3.4
Prednisolone 3.2
IPD 3.2
Vena 3.1
Vena 3.1
Monensin 3.1
CCL 3.1
Dexon 3.1
Colombo 3.1
Salbutamol 3.0
Gelatin 3.0
Posaconazole 2.9
Gelfoam 2.9
BCG vaccine 2.9
Xanthium 2.7
Asthma 2.7
Hyaluronidase 2.6
CVA 2.5
Hyaluronidase 2.5
Prednisone 2.4
Piperacillin 2.4
Fraction 2.4
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Enzyme
macrophage elastase 9.5
neutrophil elastase 7.9
elastase 7.8
matrix metalloproteinase 10 6.3
cathepsin G 5.7
cathepsin S 5.5
beta-D-fucosidase 5.4
proteinase-3 5.3
lysyl oxidase 5.3
papain 5.3
matrix metalloproteinase 14 5.0
neutrophil collagenase 4.9
N-acetylglucosaminyltransferase III 4.8
microsomal epoxide hydrolase 4.8
BAL 4.7
interstitial collagenase 4.7
ceramide kinase 4.7
DAP II 4.7
methionine sulfoxide reductase 4.5
PPH 4.5
CYP7B1 4.5
neutral sphingomyelinase 4.4
CAO 4.0
violaxanthin de-epoxidase 4.0
cathepsin L 3.9
phosphatidylinositol-4,5-bisphosphate 3-kinase 3.8
matrix metalloproteinase 9 3.8
sphingomyelin synthase 3.6
NCP 3.5
meprin 3.3
LTA4 hydrolase 3.2
MMP 3.2
collagenase 3.1
aspartate aminotransferase 3.1
ceramidase 3.0
mu-calpain 3.0
FPS 3.0
gamma-glutamylcysteine synthetase 3.0
cathepsin H 2.9
SPC 2.9
matriptase 2.9
cruzipain 2.7
12-lipoxygenase 2.7
PTR 2.7
CPN 2.7
soluble epoxide hydrolase 2.6
MIP 2.6
lactonase 2.6
cathepsin K 2.6
caspase-6 2.5
MMP-3 2.5
caspase-6 2.5
matriptase 2.5
trypsin 2.3
cathepsin B 2.2
prolyl hydroxylase 2.2
xanthine dehydrogenase 2.2
tissue kallikrein 2.1
15-hydroxyprostaglandin dehydrogenase 2.1
factor C 2.1
SMP 2.0
heme oxygenase 2.0
chymotrypsin 1.9
sphingosine kinase 1.9
matrix metalloproteinase 2 1.8
MCS 1.8
prolyl endopeptidase 1.8
caspase-3 1.8
beta-glucuronidase 1.7
kallikrein 1.7
p100 1.6
plasmin 1.6
tryptase 1.6
MEKK1 1.6
TdT 1.5
mannanase 1.5
phosphodiesterase 1.5
ceruloplasmin 1.4
NADPH oxidase 1.4
NADPH oxidase 1.4
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Compound
O-phosphonothreonine 11.4
C8H9NO3 9.4
11-Tricosene 9.4
PIMM 8.6
Desmosine 8.3
Noleptan 8.0
AAT 7.4
Dionosil 7.3
3-methylindole 7.2
Nitroethane 7.1
Ipratropium 7.1
1,2-dithiane 6.8
Pirbuterol 6.7
Sodium hydrosulfide 6.6
Elastin 6.5
Nedocromil 6.5
Fluticasone 6.2
Fluticasone 6.0
ELA 5.7
ELA 5.7
4H-pyrido[1,2-a]pyrimidin-4-one 5.5
Isoproturon 5.4
Zinc chloride 5.3
Cefmetazole 5.1
1,2-dithiolane 5.0
FMI 5.0
Heptachlor 4.9
2-methylbutanal 4.9
Triolein 4.9
Prone 4.8
2,5-dichlorophenol 4.8
8-hydroxyguanosine 4.8
Ritalin 4.8
Diallyl disulfide 4.8
Diallyl disulfide 4.8
HSM 4.7
Aminophylline 4.7
1-Nitropyrene 4.7
Sulfinpyrazone 4.6
Glucosylceramide 4.6
Tazobactam 4.5
1,3-propanediamine 4.5
Tolazoline 4.5
Ceftizoxime 4.5
Xenon 4.4
hexuronic acid 4.4
hexuronic acid 4.3
hexuronic acid 4.3
hexuronic acid 4.3
S-methylcysteine 4.3
Florid 4.3
BAL 4.3
TEP 4.2
SHS 4.2
benzenesulfonyl fluoride 4.2
MME 4.0
Gliotoxin 3.9
CPZ 3.9
Elan 3.9
DSE 3.9
Sudan IV 3.8
Sulbactam 3.8
Oridonin 3.7
Theophylline 3.7
1,3-Butadiene 3.7
Farnesol 3.7
CdCl2 3.7
Cetirizine 3.7
Sarcosine 3.6
Triamcinolone acetonide 3.6
Elan 3.6
Isoflavone 3.6
CO2 3.6
APN 3.6
Formoterol 3.5
Matrine 3.5
Matrine 3.5
Matrine 3.5
Mesna 3.5
Heparan sulfate 3.5
more...