Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0034067 (emphysema)
 11,506 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 735
COPD 468
Mol 460
elastin 351
neutrophil elastase 290
alpha 1-antitrypsin 255
collagen 252
FEV 187
She 154
alpha-1-antitrypsin 127
protease inhibitor 120
cytokine 120
matrix metalloproteinase 103
CO2 101
endoplasmic reticulum 84
Alpha-1 antitrypsin 82
HNE 81
AAT 74
MRI 74
MMP-9 73
TNF 71
MMP-12 68
IL-6 61
Pol 60
alpha-1 antitrypsin 58
caspase-3 56
vascular endothelial growth factor 54
myeloperoxidase 54
Mal 53
tumor necrosis factor 51
lymphoid 47
CD8 46
albumin 45
lipopolysaccharide 45
IL-8 45
MMP12 44
superoxide dismutase 43
serine protease inhibitor 42
CD4 40
MMP-2 39
Pseudomonas 36
metalloproteinase 36
fibronectin 36
chemokine 36
glycoprotein 35
insulin 34
cathepsin G 34
Alpha-1-antitrypsin 34
catalase 34
TNF-alpha 34
IFN 32
p53 31
IgE 31
Elastin 31
serine protease 30
GSH 30
IL-13 28
collagenase 28
klotho 27
C-reactive protein 27
LPS 27
SP-D 26
IL-10 26
IL-17 26
elastase inhibitor 26
hemoglobin 26
VEGF 25
tropoelastin 25
anti-elastase 25
lactate dehydrogenase 24
cage 23
p38 23
serine proteinase inhibitor 23
heme oxygenase-1 23
IgA 23
fibrillin 23
inducible nitric oxide synthase 23
lysyl oxidase 22
IL-4 22
transforming growth factor-beta 21
Nrf2 21
MAPK 21
Gen 21
EPA 21
glutathione peroxidase 20
Rec 20
proteinase 3 20
mucin 20
MMP-1 20
reserved 19
phosphodiesterase 19
TLR4 19
erythroid 19
BAL 19
thymus 18
fibrinogen 18
matrix metalloproteinase 12 18
IL-1 18
interleukin-6 18
IFN-gamma 17
all-trans 17
Proteinase 17
TGF-beta 17
alanyl 17
ERK 17
thrombin 17
secretory leukocyte protease inhibitor 17
vascular endothelium 17
antichymotrypsin 16
CD11b 16
interferon 15
MCP-1 15
surfactant protein C 15
granulocyte 15
p21 15
ATP 15
Klotho 14
MRC 14
Fas 14
NMR 14
metalloelastase 13
mTOR 13
proteasome 13
antithrombin 13
histone deacetylase 13
alkaline phosphatase 13
polypeptide 13
serum protein 13
ubiquitin 13
histone 13
proliferating cell nuclear antigen 13
CD34 12
chymotrypsin 12
Surfactant protein D 12
hole 12
ERK1 12
metalloprotease 12
Met 12
PBS 12
proteoglycan 12
MMP 12
Vascular endothelial growth factor 12
ENT 12
mast cell 12
ROS 12
type I collagen 12
hepatocyte growth factor 12
IL-18 12
H. influenzae 11
adiponectin 11
pallid 11
cathepsin L 11
CRP 11
p38 mitogen-activated protein kinase 11
MIP 11
C1 inhibitor 11
SP-C 11
Smad3 11
MMP9 11
p16 11
more...
Disease
emphysema 11506
chronic obstructive pulmonary disease 2172
pneumothorax 959
asthma 932
chronic bronchitis 853
lung disease 682
lung cancer 473
COPD 468
pneumonia 421
cancer 407
pulmonary fibrosis 377
bronchiectasis 322
bronchitis 320
bronchitis 319
pulmonary hypertension 291
respiratory failure 248
cystic fibrosis 222
bronchiolitis 218
idiopathic pulmonary fibrosis 217
cirrhosis 207
AAT deficiency 199
interstitial pneumonia 181
tumor 175
liver disease 166
hypertension 163
diabetes 153
tuberculosis 150
interstitial lung disease 146
respiratory disease 133
Thorax 121
bronchopulmonary dysplasia 119
cor pulmonale 107
pneumopericardium 101
sepsis 101
pulmonary edema 98
heart disease 91
sarcoidosis 90
sepsis 89
atherosclerosis 87
carcinoma 85
pneumoconiosis 85
genetic disorder 84
Thoracic 82
tension pneumothorax 80
rheumatoid arthritis 77
hernia 76
pulmonary tuberculosis 76
adult respiratory distress syndrome 75
depression 71
dysphagia 68
obesity 65
heart failure 64
stroke 63
osteoporosis 62
malnutrition 61
adenocarcinoma 57
cardiovascular disease 56
primary pulmonary hypertension 55
myocardial infarction 54
influenza 54
silicosis 53
mediastinitis 52
Langerhans cell histiocytosis 49
hyaline membrane disease 49
pulmonary embolism 49
lymphangioleiomyomatosis 48
lung carcinoma 48
coronary artery disease 46
congestive heart failure 45
bronchopneumonia 44
HIV 44
small airways disease 44
myocardial ischemia 43
empyema 43
hepatocellular carcinoma 40
cutis laxa 40
Boerhaave's syndrome 40
hepatitis 39
vascular disease 39
vasculitis 39
ischemia 38
ventricular hypertrophy 37
obstructive airway disease 37
cold 36
infectious diseases 36
SEM 35
arthritis 35
metastases 34
chronic liver disease 34
bronchogenic carcinoma 34
carcinogenesis 34
Orbital emphysema 33
anemia 33
ARF 33
fasciitis 32
CLE 32
bronchospasm 31
gastroesophageal reflux disease 31
squamous cell carcinoma 31
panniculitis 31
dementia 30
coronary heart disease 30
AIDS 30
GSH 30
chronic disease 30
hypersensitivity pneumonitis 30
virus infection 29
peritonitis 29
suicide 28
eosinophilia 28
lymphadenopathy 27
asbestosis 27
gastritis 27
arteriosclerosis 27
Marfan syndrome 27
rare disease 27
respiratory infection 26
dermatomyositis 26
Haemophilus 26
West 26
Esophageal 26
scrotum 25
obstructive sleep apnea 25
aspiration pneumonia 25
dysplasia 24
immunodeficiency 23
renal failure 23
dysphonia 22
proptosis 22
respiratory acidosis 22
aspergillosis 22
leukemia 22
gas gangrene 22
alcoholism 22
pneumocephalus 22
Emphysematous gastritis 21
Infection 21
prolapse 21
muscular atrophy 21
cardiomyopathy 21
ulcerative colitis 21
Nose 21
lung abscess 21
non-small cell lung cancer 21
diverticulitis 20
connective tissue disease 20
bacterial infection 20
cytomegalovirus 20
pleurisy 20
pyelonephritis 20
prematurity 19
lymphoma 19
fungal infection 19
bacterial pneumonia 18
gastric cancer 18
infertility 18
aortic aneurysm 18
cellulitis 18
intraocular pressure 18
right heart failure 18
more...
Symptom
dyspnea 735
respiratory distress 394
anesthesia 279
cough 270
pain 209
chest pain 151
collapse 145
hemoptysis 107
vomiting 106
hypercapnia 103
shortness of breath 96
wheezing 77
exertional dyspnea 59
abdominal pain 56
cyanosis 48
weakness 43
analgesia 41
diarrhea 40
fatigue 37
hoarseness 34
stridor 31
chronic cough 29
tachypnea 28
neck pain 28
discomfort 26
discomfort 26
sneezing 23
productive cough 23
sore throat 21
hyperoxia 21
nausea 19
anorexia 17
epigastric pain 16
seizures 14
nausea and vomiting 13
clubbing 12
ENT 12
erythema 11
angina 11
chest tightness 11
back pain 11
headache 11
starvation 11
cachexia 11
constipation 9
ataxia 9
regurgitation 9
retching 9
rales 9
hypothermia 9
exhaustion 8
sleepiness 8
paresis 8
pleuritic chest pain 8
thinning 7
nasal discharge 7
shoulder pain 7
Respiratory symptoms 7
Ill 7
Air trapping 6
persistent cough 6
splenomegaly 6
syncope 6
tremor 6
overweight 6
functional recovery 5
agitation 5
thigh pain 5
pallor 5
Lung hyperinflation 5
emaciation 5
labored breathing 5
chills 4
breath holding 4
acute abdomen 4
myalgia 4
rhinorrhea 4
polyuria 4
hemiplegia 4
colic 4
spasm 4
lethargy 4
otalgia 3
leg pain 3
non-productive cough 3
hypocapnia 3
Blotchy 3
hopelessness 3
aphonia 3
flank pain 3
neuralgia 3
numbness 3
ophthalmoplegia 3
chronic constipation 3
Physical findings 3
alexithymia 3
Postoperative pain 3
pelvic pain 3
dizziness 3
hepatomegaly 3
hepatosplenomegaly 3
hip pain 3
snoring 3
low back pain 2
orthopnea 2
Postoperative nausea and vomiting 2
nocturnal cough 2
hypertonia 2
fever of unknown origin 2
hypotonia 2
spasticity 2
nasal congestion 2
Wind 2
night sweats 2
frequent urination 2
bloating 2
oliguria 2
swollen scrotum 2
arthralgia 2
livedo 2
heartburn 2
abnormal breathing 2
drooling 2
memory loss 2
catarrh 2
hyperemesis gravidarum 2
abdominal discomfort 2
dysarthria 2
Platypnea 2
polydipsia 2
acute abdominal pain 2
hypoproteinemia 2
eye pain 2
decreased appetite 2
acute pain 2
Bronchial breathing 1
vertigo 1
belching 1
monoplegia 1
incoordination 1
hot flushes 1
despair 1
exertional angina 1
skin damage 1
Nasal symptoms 1
apathy 1
photopsia 1
muscle cramps 1
photophobia 1
feeling of choking 1
abdominal fullness 1
bigeminal 1
stigma 1
iliac fossa pain 1
Opposition 1
excessive sweating 1
diastolic murmurs 1
Hoover's sign 1
Diaphragmatic weakness 1
Thoracic pain 1
more...
Drug
Cardiovasc 153
Asthma 59
Dermatol 29
lysine 19
ascorbate 19
IFN-gamma 17
MRC 14
vitamin E 13
Prolastin 13
ENT 12
ROS 12
Monit 11
Papain 10
Leaf 9
CSF 8
Theophylline 8
SF6 8
Survanta 7
Gel 7
ATV 6
Heme 6
ROC 6
Prednisolone 5
lactose 5
Glutathione 5
Vitamin E 5
Fraction 5
Talc 5
Gelatin 5
Helium 5
MAP 4
Dakar 4
Retinoic acid 4
Ipratropium bromide 4
ACT 4
CCL 4
p75 4
ICI 3
TTC 3
CaCl2 3
Salbutamol 3
Pirfenidone 3
Sodium hypochlorite 3
G-CSF 3
Vitamin A 3
Ritalin 3
Monensin 3
CaCl2 3
Silica 3
Itraconazole 3
CPR 3
CaCl2 3
Bayer 3
Mutagen 3
BCG vaccine 3
Nephron 2
ZnO 2
TAC 2
Roflumilast 2
Growth hormone 2
IL-11 2
CDX 2
Spectrum 2
TPV 2
Gelfoam 2
PTC 2
CDX 2
Histamine 2
SiO2 2
ampicillin 2
ETS 2
Growth hormone 2
Rolipram 2
Biopolymers 2
TiO2 2
PCP 2
Xanthium 2
Nephron 2
Sinemet 2
Spiriva 2
SBT 2
Parkin 2
caffeine 2
Prednisone 2
Alliance 2
Atrovent 2
Parkin 2
PFT 2
Lasalocid 2
IL-2 2
CPZ 2
Roflumilast 2
Simvastatin 1
Triad 1
Hyaluronidase 1
Meth 1
CTX 1
Budesonide 1
IPD 1
FLM 1
PFA 1
MIL 1
uPA 1
Adenosine deaminase 1
EPA 1
Berotec 1
Ganciclovir 1
Triad 1
Polydioxanone 1
Erlotinib 1
Arachidonic Acid 1
Posaconazole 1
Dexon 1
Dried yeast 1
Fentanyl 1
CVA 1
Colfosceril palmitate 1
Indomethacin 1
Terbutaline sulfate 1
Frovatriptan 1
Hyaluronidase 1
Citrus unshiu peel 1
Fluorescein 1
ZnCl2 1
Pimobendan 1
Domin 1
Aprotinin 1
Fenoterol 1
Piperacillin 1
NVP 1
Lipiodol 1
Molsidomine 1
Spectrum 1
Seratrodast 1
CAM 1
PAPM/BP 1
Frontal 1
Bisolvon 1
Ferric oxide 1
Sodium nitroprusside 1
Hypaque 1
Cordarone 1
Phentolamine 1
ZnCl2 1
Panipenem 1
Trib 1
Fluorescein 1
DEX 1
Ethanol 1
Photofrin 1
Pronase 1
CA-074 1
Azithromycin 1
Dial 1
Gastro 1
Vicryl 1
Vitamin K 1
DNase I 1
Colombo 1
DMSA 1
more...
Enzyme
elastase 724
neutrophil elastase 341
papain 94
trypsin 77
aspartate aminotransferase 65
peroxidase 59
collagenase 58
superoxide dismutase 50
mitogen-activated protein kinase 46
catalase 45
caspase-3 45
macrophage elastase 38
ERK 34
cathepsin G 34
lactate dehydrogenase 27
glutathione peroxidase 21
BAL 19
phosphodiesterase 19
lysyl oxidase 18
focal adhesion kinase 17
thrombin 17
chymotrypsin 15
proteasome 14
MMP 14
alkaline phosphatase 13
matrix metalloproteinase 9 11
MIP 11
cathepsin L 11
NADPH oxidase 11
ACE 10
alanine aminotransferase 10
plasmin 10
NADPH oxidase 10
reverse transcriptase 9
interstitial collagenase 9
beta-glucuronidase 9
ATPase 8
microsomal epoxide hydrolase 8
protein kinase C 8
glutathione reductase 8
cathepsin S 8
MMP-3 7
cathepsin B 7
renin 7
acid phosphatase 7
xanthine oxidase 7
SPC 7
succinate dehydrogenase 7
thromboplastin 7
kallikrein 7
luciferase 7
glutathione S-transferase 6
heme oxygenase 6
protein kinase 6
caspase-1 6
MEK 5
lysozyme 5
urokinase-type plasminogen activator 5
proteinase-3 5
neutral sphingomyelinase 5
AST 5
ceruloplasmin 5
soluble epoxide hydrolase 5
glucose-6-phosphate dehydrogenase 5
NQO1 5
AMP-activated protein kinase 4
chitinase 4
gamma-glutamylcysteine synthetase 4
CAD 4
acetylcholinesterase 4
CPR 4
beta-lactamase 4
CAD 4
CAD 4
diaphorase 4
glucose oxidase 4
NO synthase 4
cathepsin K 4
lipoxygenase 4
RNA polymerase 3
tryptase 3
MAP 3
APC 3
prolyl hydroxylase 3
lipase 3
granzyme B 3
arginase 3
matrix metalloproteinase 2 3
transcriptase 3
mu-calpain 2
protein phosphatase 2A 2
NOS 2
RNase 2
cdc2 2
caspase-8 2
caspase-9 2
glyceraldehyde-3-phosphate dehydrogenase 2
MEKK1 2
RNase 2
neuraminidase 2
phosphatidylinositol 3-kinase 2
beta-glucosidase 2
beta-galactosidase 2
hyaluronidase 2
hyaluronidase 2
phospholipase A2 2
pepsin 2
glyceraldehyde-3-phosphate dehydrogenase 2
peroxiredoxin 2
methionine sulfoxide reductase 2
cytochrome oxidase 2
neutrophil collagenase 2
calcineurin 2
12-lipoxygenase 2
phosphoglycerate kinase 2
cholinesterase 2
glyceraldehyde-3-phosphate dehydrogenase 2
glyceraldehyde-3-phosphate dehydrogenase 2
endonuclease 2
enolase 2
creatine kinase 2
meprin 2
alcohol dehydrogenase 2
xanthine dehydrogenase 2
PDE 2
CD10 2
BMT 2
cathepsin D 2
glyceraldehyde-3-phosphate dehydrogenase 2
citrate synthase 2
beta-glucosidase 2
PARP 2
PPH 2
TdT 2
tissue kallikrein 2
NADH dehydrogenase 2
complex I 2
PCP 2
diamine oxidase 2
phosphoinositide 3-kinase 2
ribonuclease 1
myosin light chain kinase 1
ADH 1
PDK1 1
carboxypeptidase Y 1
apyrase 1
caspase-6 1
CPT 1
caspase-6 1
CAO 1
sphingomyelin synthase 1
violaxanthin de-epoxidase 1
ribonuclease 1
demethylase 1
MAT 1
alpha-glucosidase 1
pyruvate kinase 1
p100 1
alpha-mannosidase 1
histone acetyltransferase 1
more...
Compound
Dec 822
oxygen 727
Clin 677
CO2 393
water 222
DNA 193
serine 111
nitrogen 92
His 79
TNF 71
calcium 61
Pac 58
cysteine 56
hydrogen 55
AAT 55
cadmium 54
sodium 53
nitric oxide 50
glucose 43
retinoic acid 41
iron 40
phosphate 40
methionine 39
lysine 36
GSH 36
GSH 36
Cardiol 35
barium 33
Elastin 31
copper 30
alanine 30
acetate 28
zinc 27
sulfate 27
bromide 26
H2O2 25
Phe 25
urea 24
tryptophan 24
3-methylindole 24
tryptophan 23
tryptophan 23
tryptophan 23
creatinine 22
leucine 20
N-acetylcysteine 20
aluminum 19
BAL 19
arginine 18
salt 18
valine 17
vitamin D 16
ATP 15
ethanol 15
formaldehyde 15
silicon 15
Optimal 15
proline 15
threonine 14
iodine 14
dUTP 14
Nicotine 14
tyrosine 14
Collagen 14
NH2 13
Theophylline 13
formaldehyde 12
titanium 12
Serine 11
CAT 11
PAS 11
CAT 11
CAT 11
N2O 11
ASA 11
glutamate 10
A 3 10
chromium 10
nitrate 10
CdCl2 10
nickel 10
silver 10
A 71 9
hyaluronic acid 9
Salt 9
galactose 9
NAD 8
Xenon 8
PEG 8
cAMP 8
Ascorbic acid 8
chromate 8
TOF 8
THP 8
THP 8
Isoproterenol 8
SO2 8
MTT 8
mercury 8
aldehyde 8
DBA 7
Ile 7
Dexamethasone 7
DBA 7
Asp 7
benzene 7
retinol 7
Gly 7
ammonium 7
potassium 7
DBA 7
NAD 7
prostacyclin 7
Lactate 6
Cer 6
guanidine 6
Heme 6
cobalt 6
Desmosine 6
8-OHdG 6
tin 6
A 1 6
PGE2 6
GlcNAc 6
PMA 6
selenium 6
H2S 6
cGMP 6
BCG 6
Heparan sulfate 5
Cocaine 5
Prednisolone 5
glutamine 5
A 42 5
THE 5
Vitamin D 5
aldehyde 5
Aminophylline 5
phosphorus 5
BLM 5
superoxide radical 5
AAA 5
Nitrite 5
ammonia 5
ClO 5
GSSG 5
Vitamin E 5
Cysteine 5
formic acid 4
Trypsin 4
DEAE 4
EDTA 4
NADPH 4
Triton X-100 4
formic acid 4
carbonate 4
AMP 4
GMP 4
Salbutamol 4
DTPA 4
more...