Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0034067 (emphysema)
 11,506 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Philip Morris promised to "shut down instantly"if cigarettes were found to be harmful. Now that the company has admitted that "smoking causes lung cancer, heart disease, emphysema, and other serious diseases", when will they keep their promise to stop making cigarettes?
Tob Control 2003 Jun
PMID:A promise is a promise. 1277 12

A nationwide survey of 776 U.S. residents, divided approximately equally between teenagers and adults, smokers and nonsmokers, assessed public understanding of the illnesses caused by smoking. When respondents were asked what illnesses are caused by smoking, lung cancer was the only illness that could be identified by a clear majority of respondents. Roughly half mentioned emphysema. A much smaller percentage of respondents were able to mention any cardiovascular disease or any kind of cancer other than lung cancer. People also underestimated the death rate from lung cancer and overestimated survival duration. Only a minority realized that emphysema is incurable. Large portions of the sample said they knew only a little about the pain and suffering experienced by individuals with these illnesses. The results demonstrated that even though people recognize that smoking can lead to adverse health consequences, they do not have even a basic understanding of the nature and severity of these consequences.
Nicotine Tob Res 2004 Apr
PMID:Public understanding of the illnesses caused by cigarette smoking. 1520 8

Cigarette smoking is a major risk factor in the development of various lung diseases, including pulmonary emphysema, pulmonary fibrosis, and lung cancer. The mechanisms of these diseases include alterations in alveolar epithelial cells, which are essential in the maintenance of normal alveolar architecture and function. Following cigarette smoking, alterations in alveolar epithelial cells induce an increase in epithelial permeability, a decrease in surfactant production, the inappropriate production of inflammatory cytokines and growth factors, and an increased risk of lung cancer. However, the most deleterious effect of cigarette smoke on alveolar epithelial cells is cell death, i.e., either apoptosis or necrosis depending on the magnitude of cigarette smoke exposure. Cell death induced by cigarette smoke exposure can largely be accounted for by an enhancement in oxidative stress. In fact, cigarette smoke contains and generates many reactive oxygen species that damage alveolar epithelial cells. Whether apoptosis and/or necrosis in alveolar epithelial cells is enhanced in healthy cigarette smokers is presently unclear. However, recent evidence indicates that the apoptosis of alveolar epithelial cells and alveolar endothelial cells is involved in the pathogenesis of pulmonary emphysema, an important cigarette smoke-induced lung disease characterized by the loss of alveolar structures. This review will discuss oxidative stress, cell death, and other damage to alveolar epithelial cells induced by cigarette smoke.
Tob Induc Dis 2003 Sep 15
PMID:Oxidative stress, cell death, and other damage to alveolar epithelial cells induced by cigarette smoke. 1957 Feb 63