Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034067 (emphysema)
 11,506 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In rats exposed for 12 weeks to the mixture of nitric oxides (0.34--2.81 mg/m3) and chlorine (0.61--1.50 mg/m3) the following changes were found: increased methemoglobin concentration (MetHb), increased partial pressure, increased total carbon dioxide concentration (pCO2 TCO2), increased current dicarbonate concentration (AB), and increased buffer bases (BB). In addition, asparagine transferase activity (aspAT), alanine aminotransferase (A1AT), alkaline phosphatase (AP) and hepatic isoenzyme of lactic dehydrogenase (LDH5) in serum were found to be increased. Histopathological examination revealed: inflammatory lesions and edema of pulmonary parenchyma, alveolar emphysema and edema of connective tissue of palpetra derm with mastocytes. Chronic exposure to low concentrations of nitric oxides and chlorine induces, apart from local lesions in conjunctivae, pulmonary lesions leading to respiratory acidosis compensated by metabolic alkalosis, or liberation of indicatory enzymes through impaired cells.
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PMID:[Chemical hazards connected with electrochemical machining. I. Toxicity of nitric oxides and chlorine lesions in rats' parenchymatous organs]. 50 41

A total of 136 patients with trans- and 200 with non-transmural myocardial infarction (MI) were examined over time for chlorine-soluble mucoprotein (MP), serum hexoses (SH), their fraction-hexoses of glycosaminoglycans (H-GAG), and hexoses of glycoproteins (H-GP), serum, plasma and urine hydroxyproline (SHP, PHP, UHP). The computation of regressions made it possible to prove multidirectional changes in chlorine-soluble MP, SH, H-GAG, SHP, PHP, and in UHP. Approximation of the curves enabled MI patients to be distributed into subgroups marked by rapid and moderate repair tempo. The factors that prolong MI repair according to the X-square test are as follows: age over 60 years, heart aneurysms, recurrent MI, chronic grade 2A heart failure, diabetes mellitus, chronic bronchitis combined with lung emphysema and stage 2 respiratory failure. That whether MI is transmural or non-transmural is not per se the sole factor determining MI repair.
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PMID:[Clinical regularities of myocardial infarction repair]. 276 91