Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034067 (emphysema)
 11,506 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A comparative study was made of the action of 5 intratracheally introduced dusts (of manganese, silicon, potassium, natrium, calcium, fluorine, and iron) on the cardio-respiratory system. A more marked biologic activity of the hard component of welding aerosols with a high content of fluorine, potassium and soluble manganese compounds was established. This was proved by structural damages, such as atelectasis, emphysema, bronchiectasis in the lungs, dystrophic developments in the contractual myocardium, a sharp decrease in the luminescent intensity of the adrenergic terminals in the myocardium. All the welding dust samples did not display a fibrogenous activity in any degree.
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PMID:[Effects of welding dust on morphology of the bronchopulmonary system and heart in experimental animals]. 226 51

The liver, heart, lungs, and stomach of rats exposed to hydrogen fluoride were studied. Histological examination showed partial liver necrosis and emphysema. Using histochemical methods the effect of fluorine ions was found in: a reduction of the activity of succinic and beta-hydroxybutyric dehydrogenases in the liver, heart muscle, superficial and glandular epithelium cells, and in lamina propria of the gastric mucosa; an increase in the activity of lactate dehydrogenase in liver cells; an increase in the activity of acid phosphatase in the liver, heart muscle, bronchus epithelium, bronchioli, and interalveolar septum cells; an increase in the activity of alkaline phosphatase in the liver, lungs, and heart muscle connective tissue, and in all gastric epithelium cells. The results obtained mainly point to the inhibition of oxidative metabolism by fluoride ions.
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PMID:Studies on the toxicology of fluorine compounds. I. Histological and histochemical investigations on the liver, heart, lungs, and stomach of rats exposed to hydrogen fluoride. 261 87