Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0034067 (
emphysema
)
11,506
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Elastase anti-elastase imbalance theory is most important in the pathogenesis of COPD (pulmonary
emphysema
). Proteolytic activity of neutrophil elastase (NE) plays an important role because of the detachment of cells through proteolysis of extracellular matrix. In addition to proteolytic activity of NE, NE-induced activation of intracellular signaling (MAPK(Erk), Rho and
MLCK
) participates in NE-induced morphological changes in airway epithelial cells.
...
PMID:[Elastase anti-elastase imbalance in the pathogenesis of COPD]. 1049 94
