Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034067 (emphysema)
 11,506 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The National Alliance for the Mentally Ill is challenging the funding policies of the National Institute of Mental Health (NIMH), claiming that NIMH spends a disproportionate amount on AIDS research. A review of 2,277 abstracts of NIMH-funded projects in 1997 showed that the agency spent 14.2 percent of its budget studying behavioral aspects of HIV and 13.5 percent on schizophrenia. NIMH responded that HIV was a serious and significant health threat among mentally ill persons, including the homeless. The quarrel was fueled by a 1999 New England Journal of Medicine article suggesting that AIDS receives a disproportionate share of spending compared to other diseases, such as breast cancer and emphysema.
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PMID:Mental health advocates complain about NIMH priority for AIDS. National Institute of Mental Health. 1136 24

A major initiative of the Quantitative Imaging Biomarker Alliance is to develop standards-based documents called "Profiles," which describe one or more technical performance claims for a given imaging modality. The term "actor" denotes any entity (device, software, or person) whose performance must meet certain specifications for the claim to be met. The objective of this paper is to present the statistical issues in testing actors' conformance with the specifications. In particular, we present the general rationale and interpretation of the claims, the minimum requirements for testing whether an actor achieves the performance requirements, the study designs used for testing conformity, and the statistical analysis plan. We use three examples to illustrate the process: apparent diffusion coefficient in solid tumors measured by MRI, change in Perc 15 as a biomarker for the progression of emphysema, and percent change in solid tumor volume by computed tomography as a biomarker for lung cancer progression.
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PMID:Statistical Issues in Testing Conformance with the Quantitative Imaging Biomarker Alliance (QIBA) Profile Claims. 2689 27