Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034067 (emphysema)
 11,506 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The prevalence of illicit drug use is higher among men than women, but new drug use occurs at twice the rate for females as for males. Recent data from emergency rooms and medical examiners support this pattern, but females were more likely than males to report use of tranquilizers, antidepressants, and some nonbarbiturate sedatives. Recent data show that men outnumbered women in drug treatment admissions for all drugs except tranquilizers. However, the 1984 National Institute of Mental Health Epidemiologic Catchment Area Survey shows drug abuse and dependence to be the second most commonly reported disorder for women. Smoking is the most common form of drug dependence in our society, and it has a major impact on women's health. Lung cancer is now the leading cause of cancer deaths among women. Smoking poses a special risk of coronary heart disease for women using oral contraceptives. The incidence of emphysema among women has also risen sharply. Smoking during pregnancy carries special, serious risks. Research strongly suggests that the use of marijuana during pregnancy carries significant risks, including low birth weights and fetal abnormalities. Opiate addiction among women is uncommon, but it carries disproportionate health risks for these women and their offspring; infants born of addicted mothers have much higher morbidity and mortality rates than infants in general. Acquired immune deficiency syndrome is a grave risk to women using intravenous drugs and to their children. There are a number of health problems associated with psychoactive drug use among elderly women. In addition to research, the National Institute on Drug Abuse has focused a number of its activities on the special problems and needs of women. The Institute is collaborating with the health care community to place increased emphasis on prevention and treatment services for women and is working with organizations in the public and private sector to ensure that current information about drug use is effectively disseminated.
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PMID:Substance abuse and women's health. 312 Feb 20

Objective to review the experience of the lung transplantation unit at Hospital La Fe (Valencia). Between February 1990 and March 1996 we performed 40 lung transplants. The following causes were most common: cystic fibrosis (9 cases), emphysema (8), pulmonary fibrosis (8) and bronchiectasis (7). Types of intervention were 27 double lung transplants (25 sequential and 9 blocked), 9 single lung transplants, and 4 heart-lung transplants. We then reviewed the 36 single and double lung transplants. The main exclusion criteria were age over 65 years, malignant disease, kidney or liver disease, severe or non reversible central nervous system disease, and drug addiction. Prior surgery, mechanical ventilation and the presence of Aspergillus were considered lower-order contraindications. Mean patient age was 37.7 years (14-59). Six patients were colonized by Aspergillus before transplantation. Five had undergone earlier surgery and two were mechanically ventilated before the transplant. The most common complication was respiratory infection, which was present in 6 of the 7 patients who died. Other complications in order of frequency were dehiscence and/or bronchial stenosis, corticoid myopathy and postoperative bleeding. The actuarial survival rate of single and double lung transplants was 67.85 after 3 years, and 87.5% in patients with cystic fibrosis. Lung transplantation is a well-established procedure that is gradually being extended to treat more conditions. The main obstacle is the scarcity of donors. The main challenge at present is bronchiolitis obliterans.
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PMID:[1990-1996: the experience of the La Fe Lung Transplant Group (Valencia)]. 942 59

The purpose of this study is to determine how the demographics of perceivers influence their stigma of people with mental illness or with substance abuse. A nationally representative sample (N = 968) was asked to respond to a vignette describing a person with a health condition (schizophrenia, drug dependence, or emphysema) and his/her family member. Consistent with our hypotheses, women were less likely to endorse stigma than men. Participants with higher education were also less likely to stigmatize than less educated participants. Contrary to our expectations, nonwhite research participants were more likely to endorse stigma than whites. Implications of these findings for better understanding the stigma of mental illness, and the development of anti-stigma programs, are reviewed.
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PMID:The stigma of psychiatric disorders and the gender, ethnicity, and education of the perceiver. 1787 5

Talc is a mineral widely used in the ceramic, paper, plastics, rubber, paint, and cosmetic industries. Four distinct forms of pulmonary disease caused by talc have been defined. Three of them (talcosilicosis, talcoasbestosis, and pure talcosis) are associated with aspiration and differ in the composition of the inhaled substance. The fourth form, a result of intravenous administration of talc, is seen in drug users who inject medications intended for oral use. The disease most commonly affects men, with a mean age in the fourth decade of life. Presentation of patients with talc granulomatosis can range from asymptomatic to fulminant disease. Symptomatic patients typically present with nonspecific complaints, including progressive exertional dyspnea, and cough. Late complications include chronic respiratory failure, emphysema, pulmonary arterial hypertension, and cor pulmonale. History of occupational exposure or of drug addiction is the major clue to the diagnosis. The high-resolution computed tomography (HRCT) finding of small centrilobular nodules associated with heterogeneous conglomerate masses containing high-density amorphous areas, with or without panlobular emphysema in the lower lobes, is highly suggestive of pulmonary talcosis. The characteristic histopathologic feature in talc pneumoconiosis is the striking appearance of birefringent, needle-shaped particles of talc seen within the giant cells and in the areas of pulmonary fibrosis with the use of polarized light. In conclusion, computed tomography can play an important role in the diagnosis of pulmonary talcosis, since suggestive patterns may be observed. The presence of these patterns in drug abusers or in patients with an occupational history of exposure to talc is highly suggestive of pulmonary talcosis.
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PMID:Pulmonary talcosis: imaging findings. 2015 72