Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034067 (emphysema)
 11,506 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chronic lung disease (CLD) in infants was studied in 50 autopsy cases clinicopathologically. These cases were divided into three groups clinically. Pathological changes in the lung were similar among these three groups. Changes of elastic fibers in the alveolar septum were characteristic; irregular and unevenly distributed elastic fibers were found in the majority of CLD cases. The abnormally distributed elastic fibers could contribute to occurrence of focal emphysema. The lungs from 5 special cases were devoid of elastic fibers in the alveolar septum. In such cases, abnormality of elastin production by fibroblasts or abnormal interaction between protease and anti-protease was hypothesize as the mechanism of occurrence. The relationship to adult lung diseases was also discussed.
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PMID:[Pathological changes and pathogenesis of chronic lung diseases in infants]. 204 Dec 55

Chronic lung disease is a leading cause of morbidity and mortality in the United States. Quantitative techniques for assessing emphysema and related airway disease have been slow to gain acceptance among radiologists, who have traditionally used description of structural changes to evaluate these diseases. This review provides an overview of these quantitative techniques.
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PMID:Quantitative CT of emphysema and the airways. 1550 10

Chronic lung disease (CLD) is one of the most common long-term complications in very preterm infants. Bronchopulmonary dysplasia (BPD) is the most common cause of CLD in infancy. Modern neonatal respiratory care has witnessed the emergence of a new BPD that exhibits decreased fibrosis and emphysema, but also decreased alveolar septation, and microvascular development. CLD encompasses the classic and the new BPD, and recognizes that lung injury can occur in term infants who need aggressive ventilatory support and who develop lung injury as a result, and that CLD is a multisystem disease. Controversy exists on whether quality improvement (QI) methods that implement multiple interventions will be effective in limiting pathology with multiple causes. Caution in generalization of QI findings is encouraged. QI methods toward improvement in CLD or any other outcome should be considered as a tool for implementing evidence and studying the effects of change in complex adaptive systems.
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PMID:Quality improvement in respiratory care: decreasing bronchopulmonary dysplasia. 2036 59