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Query: UMLS:C0034067 (emphysema)
 11,506 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chronic obstructive lung disease (COLD) is a clinical entity characterized by chronic airway obstruction that includes pulmonary emphysema and chronic bronchitis with airway obstruction. Although most complications are treated medically, there are a few cases in which medical treatment is not effective and surgical treatment is necessary. Most complications of COLD requiring surgical treatment are those associated with bullous emphysema, such as pneumothorax, lung carcinoma associated with bulla, and infection of bulla. In this article, the indications, practical aspects, and problems and risks of surgical treatment for complications of COLD are discussed.
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PMID:Surgery for complications of chronic obstructive lung disease. 857 64

A case-control study involving 390 lung cancer cases, matched 1:1 with controls, was carried out in Guangdong Province to compare risk factors for different histopathologic types of lung cancer in both sexes. Female and male lung cancers appear to differ in epidemiological characteristics, pathologic types, and risk factors. The 291 lung cancer cases in males were predominantly squamous cell lung carcinoma (squamous cell carcinoma/adenocarcinoma = 1:0.5), whereas the 99 female lung cancer cases were predominantly adenocarcinoma (squamous cell carcinoma/adenocarcinoma = 1:2.7). The age at which lung cancer was first diagnosed was lower for females than for males (P < 0.0001). Single-factor conditional logistic regression analysis showed an association of lung cancer with family history of tumors, family history of lung cancer, history of chronic bronchitis/emphysema, history of tuberculosis, history of other lung disease, smoking, exposure to environmental tobacco smoke (ETS) in the home and in the workplace, being professional drivers, use of oral contraceptives, and consumption of pickled and salted fish (P < 0.05). Further multivariate logistic regression analysis showed that family history of tuberculosis, history of chronic bronchitis/emphysema, family history of tumors, smoking, exposure to ETS in the home and in the workplace, and consumption of pickled and salted fish were independent risk factors for lung cancer. Using log-linear model analysis, it was confirmed that lung cancer had significant interactions with chronic bronchitis/emphysema, exposure to ETS, history of tuberculosis and smoking. Smoking, however, could only explain 1/5 of the incidence of female lung cancers. Family history of lung cancer and the use of oral contraceptives were related to lung cancer in women. Except for a weak relationship with history of chronic bronchitis/emphysema, adenocarcinoma was found to have no association with the other risk factors.
Lung Cancer 1996 Mar
PMID:A comparative study of the risk factors for lung cancer in Guangdong, China. 878 73

The relationship between elastin degradation and emphysema is well known. Recent evidence suggests that a complex process of pulmonary remodeling occurs within the emphysematous lung. The aim of this study was to assess the extent of extracellular matrix remodeling in emphysema by ultrastructural examination of elastin and collagen templates in an animal model of emphysema and in human emphysematous lungs. Emphysema was induced in rats by the intratracheal administration of porcine pancreatic elastase. Human lung samples were obtained at surgical resection for lung carcinoma. Emphysema was confirmed morphometrically and quantitated using the mean linear intercept. Matching sections were treated with sodium hydroxide and formic acid to expose collagen and elastin templates, respectively. Scanning electron microscopy with stereo-pair imaging allowed three-dimensional visualization of the exposed templates. In emphysematous lungs from both sources, sheets of elastin were disrupted and perforated with multiple fenestrations. In elastase-induced emphysema, this disintegration was accompanied by a marked increase in thickness of collagen fibrils, which contrasted with the fine fibrillar network of control lungs. Similarly, a pattern of thickened fibrils and disorganized deposition of collagen was observed in human lungs. In conclusion, these findings support the novel concept of increased collagen deposition and aberrant collagen remodeling in the pathogenesis of emphysema.
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PMID:Elastin and collagen remodeling in emphysema. A scanning electron microscopy study. 886 87

A patient with a small-sized pulmonary adenocarcinoma was successfully treated by percutaneous high dose rate interstitial brachytherapy alone. The patient, who had an adenocarcinoma with 12-mm diameter in the lingular lobe of left lung, was judged to be inoperable because of poor pulmonary function due to emphysema and extensive pleural adhesion. The tumor was punctured with a 21-gauge fine applicator needle followed by the introduction of an iridium 192 (192Ir) radioactive source through the applicator needle using a remote afterloader. The tumor was irradiated for 225.1 s in one fraction. The tumor was in the inside of the iso-dose line of 40 Gy. The delivered doses calculated at nine reference points, which were 12.5 mm distant from the center of the tumor, distributed between 19.225 and 32.169 Gy, with a mean of 24.8 Gy. No apparent side effect including pneumothorax and hemoptysis was observed. The tumor shrank and showed no increment of the size for about 2 years.
Lung Cancer 1999 Jun
PMID:Percutaneous brachytherapy for small-sized non-small cell lung cancer. 1046 4

Small cell carcinoma of the lung (SCLC) occurs most frequently in heavy smokers, yet exhibits a lesser predominance among men than other smoking-associated lung cancers. Incidence rates have increased more rapidly in women than men and at a faster rate among women than other cell types. To investigate the importance of smoking and other risk factors, a case-control study of SCLC in women was conducted. A total of 98 women with primary SCLC and 204 healthy controls, identified by random-digit dialing and frequency matched for age, completed telephone interviews. Data collected include demographics, medical history, family cancer history, residence history, and lifetime smoking habits. Odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated using logistic regression analysis. Risk for small cell carcinoma in women is strongly associated with current use of cigarettes. Ninety-seven of 98 cases had smoked cigarettes; 79% of cases were current smokers and 20% were former smokers at the time of diagnosis compared to 13% current and 34% former smokers among controls. The ORs associated with smoking are 108.7 (95% CI 14.8-801) for ever-use of cigarettes, 278.9 (95% CI 37.0-2102) for current smoking, and 31.5 (95% CI 4. 1-241) for former smoking. Risk increases steeply with pack-years of smoking and decreases with duration of smoking cessation. After adjusting for age, education, and lifetime smoking history, medical history of physician-diagnosed respiratory disease including chronic bronchitis, emphysema, pneumonia, tuberculosis, asthma, and hay fever is not associated with a significant increase in lung cancer risk. Employment in blue collar, service, or other high risk occupations is associated with a two to three-fold non-significant increase in risk for small cell carcinoma after adjusting for smoking.
Lung Cancer 2000 Apr
PMID:Small cell lung cancer in women: risk associated with smoking, prior respiratory disease, and occupation. 1070 3

Smoking is the leading preventable cause of death in the United States. The US Centers for Disease Control and Prevention (CDC) estimate that smoking kills approximately 419,000 people in the United States each year. Cigarette smoking is the nation's leading cause of premature mortality, and is responsible for one-third of all deaths among working-age Americans. Smoking cigarettes is both psychologically and physiologically addictive. Smoking is an important risk factor for cardiovascular diseases, especially coronary artery disease, stroke, carcinoma of the lung, chronic bronchitis, chronic obstructive pulmonary disease, and emphysema. It also increases the risk for peripheral vascular disease and is associated with cancers of the larynx, oral cavity, esophagus, pancreas, and urinary bladder. Smoking by pregnant women can cause adverse health effects on their babies, like low birth weight and preterm delivery; increases the risk of miscarriage; and has also been found to be an important cause of sudden infant death syndrome. Careless smoking also can cause severe burn injuries and death. Many of these adverse effects of smoking occur in "second-hand" smokers.
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PMID:Effects of smoking on health care costs. 1086 Feb 94

New trends in lung cancer surgery focus on new approaches to the management of the primary tumour, combined modality approaches to both local and distant control of the tumour, new approaches to ensure resectability by staging and techniques to expand the limits of operability. With new screening methods for NSCLC there is a trend toward sublobar, segmental resections of smaller tumours including an expanding use of video assisted thoracoscopy. Improvements in surgical and anaesthetic procedures have stimulated a renewed interest in the resection of locally advanced tumours. The understanding that local control alone may not give the best chance of long term survival has stimulated new trends in the use of neoadjuvant and adjuvant chemotherapy. There is a trend towards more detailed preoperative and intraoperative nodal staging in NSCLC, including video assisted techniques, and the identification of sentinel lymph node involvement to direct lymph node dissection. Increased understanding of the physiological benefits of surgery in emphysema have resulted in a re-evaluation of the selection of patients for lung cancer surgery. This together with a greater application of bronchoplastic and angioplastic techniques is leading to greater resection rates.
Lung Cancer 2001 Dec
PMID:Surgery for non-small cell lung cancer--new trends. 1172 Jul 54

We report an unusual case of a patient with a bronchopleural-subcutaneous fistula that occurred 3 years following a lobectomy and en bloc chest wall resection for carcinoma. Following a sudden resolution of subcutaneous emphysema, an epidural air collection developed. Spontaneous pneumorrhachis is a previously unreported late complication after surgical or radiation therapy for lung carcinoma.
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PMID:An unusual case of pneumorrhachis following resection of lung carcinoma. 1200 70

A bronchosubcutaneous fistula is a communication between the subcutaneous tissues, the pleural cavity, and the bronchial system. It is a rare manifestation of primary pulmonary disease. The authors present a very unusual case of bronchosubcutaneous fistula that presented as subcutaneous emphysema after palliative radiation therapy for primary carcinoma of the lung.
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PMID:Malignant bronchosubcutaneous fistula presenting as subcutaneous emphysema. 1236 72

We present a case of a 59-year-old man with small cell lung cancer (SCLC) who developed heavy thoracic pain because of spontaneous mediastinal emphysema. Autopsy documented a mucosal lesion in the posterior tracheal wall with air leak towards the mediastinum. The occurrence of spontaneous mediastinal emphysema in patients with small cell lung cancer has rarely been described in the literature.
Lung Cancer 2005 Jan
PMID:Mediastinal emphysema and small cell lung cancer (SCLC): a case-report. 1641 46


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