Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034067 (emphysema)
 11,506 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pulmonary diffusing capacity (TLco) of 19 cases of chronic obstructive lung diseases (Chronic obstructive bronchitis and chronic obstructive emphysema) in the age group of 39 to 58 years (mean age: 49.8 +/- 5.5 SD years) are reported at rest in this investigation. The diffusing capacity for carbon monoxide (TLco) measured by standard methods was significantly reduced in all cases. The mean was 13.1 +/- 2.3 SD ml/min/mmHg. The blood gas findings revealed low arterial oxygen saturation (mean value: 90.2 +/- 2.2%). Arterial carbon dioxide tension was higher than in normal subjects. The mean for this series was 44.8 +/- 4.9 SD mmHg. The mean for normal subjects was 37.5 mmHg and the range 28.2 to 41.5.
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PMID:Changes in pulmonary diffusing capacity and blood gases in chronic obstructive lung diseases. 145 27

Chronic bronchitis was a disease which attracted much attention in the U.K. in the 1950's. It was classified into three forms known as simple chronic bronchitis, recurrent or mucopurulent bronchitis, and chronic obstructive bronchitis and it was thought that the disease progressed from one form to the next in accordance with their order as listed here. Later, however, it was realized that the disease did not progress according to this order and that chronic bronchitis actually included three kinds of the disease. Furthermore, in the U.K., with the prohibition of the use of coal and the reduction of air pollution and with the decline of infectious disease in child age, recurrent or mucopurulent bronchitis underwent an extreme reduction. Chronic obstructive bronchitis is known to be caused by smoking and is now called chronic bronchitis and emphysema or COPD. Simple chronic bronchitis may in fact be only a simple physical response to smoking. Now in Japan the disease called chronic bronchitis is often recognized when written on receipts for health insurance, but patients of chronic bronchitis as were seen in the U.K. in the 1950's are extremely rare. Diffuse panbronchiolitis is seen in Japan but is a disease not found in the West. Diffuse bronchiectasis and its differentiation become the point of question for this disease. With the effectiveness of erythromycin, we can expect a decline in the number of patients and an improvement in prognosis.
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PMID:[Chronic bronchitis and related disorders]. 221 80

Chronic obstructive bronchitis and emphysema are two chronic lung diseases closely associated with cigarette smoking. Early pathological changes in the lung in asymptomatic smokers affect the alveoli and bronchioli, sites where surfactant production is centred. Bronchial lavage work has demonstrated a reduction of 'free' extra-cellular surfactant in smokers. In this report the interaction between the 'tar' of tobacco smoke and surfactant is described from in vitro studies. Also using an isolated rat lung model tobacco smoke 'tar' appears to increase lung compliance. These observations may help explain why young asymptomatic cigarette smokers have increased lung compliance and suggest the way in which 'tar' interacts with the lung surface.
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PMID:Pulmonary surfactant and chronic lung disease. 348 Aug 19

This study included 89 patients with chronic obstructive bronchitis (COB) that were exposed to harmful occupational factors. The control group consisted of 30 healthy subjects. Chronic obstructive bronchitis is characterized by serious disturbances in the cardiorespiratory system that manifest themselves in the form of bronchogenic pneumosclerosis with moderate lung emphysema and pulmonary hypertension associated with impaired general resistance. Simultaneously, activity of lipid peroxidation reactions decreases. Application of low-intensity laser radiation in combination with other therapeutic modalities for the treatment of patients with chronic obstructive bronchitis accelerates elimination of clinical symptoms, increases its efficiency, promotes drainage function of the bronchi, facilitates normalization of the patient's immune status, and contributes to the optimization of lipid peroxidation processes.
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PMID:[Low-intensity laser radiation in the combined treatment of patients with chronic obstructive bronchitis]. 1951 98