Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0034067 (emphysema)
 11,506 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Volcanic gas is one of the hazards which tourists rarely meet in mountains. We present six fatalities due to volcanic gas inhalation on Mt. Aso, an active volcano in Kumamoto, Japan, over a period of nine years (1989-1997). One accident occurred at the lip of the crater and the other five within a distance of 250 m from the lip of the crater. Four of the six fatalities had a history of bronchial asthma. A forensic autopsy was performed for a fatality with a history of hypertensive heart disease; pulmonary emphysema was disclosed for this victim. These findings supported the idea that individuals with chronic lung diseases were at higher risk of death by volcanic gas inhalation. Safety precautions are effected through regular surveillance of the area and monitoring of volcanic gas levels. The criterion for sulfur dioxide levels has been changed to a more rigorous one (from >5.0 ppm to >0.2 ppm) according to our advice based on the autopsy. Further forensic analyses will help to design additional preventive measures so as to reduce mortality resulting from inhalation of toxic volcanic gas.
 ...
PMID:Fatalities by inhalation of volcanic gas at Mt. Aso crater in Kumamoto, Japan. 1293 92

To identify the diseases that correlate with suspended particle concentration in the ambient air, a cross-sectional epidemiological study was conducted using the annual vital statistics and air pollution estimates of 1881 points throughout Japan. The concentration of suspended particulate matters (SPMs) 10 microm or less in diameter were hypothetically converted to PM(2.5) values (converted PM(2.5) or cPM(2.5)) by using a conversion factor obtained from 25 estimates in Japan. Among various causes of death, a significant correlation was observed between both the SPM and cPM(2.5) (SPM/cPM(2.5)) levels and the age-adjusted death rates of ischemic heart disease or hypertensive heart disease in both genders. Correlation was noted with pneumonia, asthma, chronic bronchitis/emphysema, or lung cancer only in females. Unexpectedly, breast, endometrial, and ovarian cancer also showed significant increases in mortality rates related to the SPM/cPM(2.5) level, suggesting a role for suspended particles in the ambient air with or without gaseous component as a possible endocrine-disrupting, estrogenic agent. Multivariate regression analysis of confounding factors, smoking rate, population density, and hormone-related factors revealed consistent significance of SPM/cPM(2.5) in these diseases.
 ...
PMID:Correlation between suspended particles in the environmental air and causes of disease among inhabitants: cross-sectional studies using the vital statistics and air pollution data in Japan. 1605 35