Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0034067 (emphysema)
 11,506 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Inhalation of the brown coal samples caused anthracosis with progressive growth in the postinhalation period and concomitant catarrhal-desquamative bronchitis, lymphoid tissue hyperplasia, emphysema, along with granuloma formation. The cases studied were marked with increased number and thickness of the argyrophile and reticuline fibres around the bronchi, vessels, granuloma and in the interalveolar septum. Changes were detected in the immunocompetent organs' state which might influence the homeostasis and the immune system. Complex cytomorphological investigation of the bronchopulmonary and immunocompetent systems can be applied to in biological studies of different aerosols.
 ...
PMID:[Biological effect of brown coal dust on the bronchopulmonary system and immunocompetent organs (experimental morphological study)]. 233 83

SO2-bronchitis, papaine-emphysema and paraquat fibrosis were induced in Wistar rats. Blood pressure, cardiac index, total peripheral resistance, arterial blood gas values, parameters of acid-base balance were determined. Effects of 0.1 and 0.3 microgram.-1.min-1 isoproterenol iv. infusion were examined. Morphologic alterations of the lungs were verified by histopathological examinations. All the parameters investigated were found to be normal in the control rats. The treated groups differed from the normal ones: an increased blood pressure was observed in emphysema and fibrosis. A decreased cardiac index was characteristic of chronic bronchitis, high cardiac index of emphysema, high TPR of bronchitis and arterial hypoxaemy of fibrosis. The groups reacted differently to beta adrenergic stimulation: in bronchitic and fibrotic rats the cardiac index was augmented, whereas in emphysematous ones the increase proved to be smaller. The effects of isoproterenol infusion can be related to the altered beta-receptor function in the various experimental pulmonary diseases.
 ...
PMID:Acid-base balance and cardiac index in SO2-bronchitic, papaine-emphysematous and paraquat-fibrotic rats after isoproterenol treatment. 233 7

The contraindication between optimal treatment and, nevertheless, increasing morbidity and mortality in bronchial asthma results in interest being focussed on patient education aimed at improving the patient's own responsibility. The decisive object of any educational measures must be to increase this sense of own responsibility. In Germany, such educational measures are rarely provided, for the most part being offered by rehabilitation centres. At the present time, statistical data on the effect of such measures are available for some 500 patients. These patients are better informed and are better able to cope with their disease on a day-to-day basis, while therapeutic discipline is improved. The patients themselves desire such education in close conjunction with hospitals (rehabilitation centres) and their own physicians. The newly founded working group Patient Education at the Germany Society for Pneumology and Tuberculosis, has set itself the task of coordinating presently available activities. In an initial phase, current activities offered are made known and matched to one another. The next step is to work put the common essentials of the educational aims, contents and forms for children and adults with asthma, bronchitis and emphysema. The final objective is to establish standards for educational programmes to be provided by hospitals and rehabilitation centres, and for pre- and post-instruction by the patient's own physician.
 ...
PMID:[A strategy for optimal standardized education of patients with obstructive respiratory tract diseases]. 236 52

Euphylong is a theophylline preparation with new galenic slow-release design (micropellets in a capsule), developed for daily single-dose administration in the evening. It has been shown that the majority of patients with bronchial asthma, chronic obstructive bronchitis or emphysema who receive a single evening dose of Euphylong have a theophylline serum concentration that remains within the therapeutic range for 24 hours when the theophylline serum concentration measured at 8 a.m. under steady-state conditions is found to lie within the therapeutic range.
 ...
PMID:[Dose titration with Euphylong following prior determination of serum concentration in the steady state]. 236 92

A pilot study was performed to assess the prevalence of hyperreactive bronchial system (HBS) in various occupational lung diseases. 204 patient records were evaluated with the following diagnosis: Allergic rhinitis: (N = 25, 12%), allergic bronchial asthma (N = 70, 34%), toxic asthma (N = 22, 11%), silicosis (N = 12, 6%), asbestosis (N = 15, 7%), farmer's lung (N = 12, 6%), chronic unspecific respiratory syndrome (N = 48, 24%). In each case an inhalative methacholine test (MCHT) was performed. HBS was considered to be present whenever there was a resistance increase of more than 100% of the baseline values. The prevalence of HBS varied between 50% (asbestosis) and 77% (toxic asthma); the average was 68%. Allergic diseases showed a higher prevalence of 71% in comparison to nonallergic diseases with 65%. Patients with silicosis or asbestosis and without additional chronic bronchitis or emphysema demonstrate a "normal" prevalence of HBS of 11%. Age, gender, smoking, alcohol, family history of allergy and repeated bronchitis, the number of eosinophils in the blood. IgE concentration in serum showed no significant association with an increased prevalence of HBS. The coincidence of anamnestically affirmed or denied bronchial hypersensitivity to environmental factors, and the positive or negative result of the MCHT test, was relatively low, being only 43% in case of a "positive" test and 17% in case of a "negative" test.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[Pilot study of the prevalence of a hyperreactive bronchial system in various occupationally-induced lung diseases]. 238 88

The bronchopulmonary system is at particular risk from environmental pollution. At the same time, numerous natural and personal confounding variables are also effective, and investigations need to give then careful consideration. In particular such diseases as pulmonary emphysema, bronchitis, obstructive airways diseases and carcinoma of the lung may be due to environmental factors. Highly reliable methods of detecting such diseases are presented. The use of these methods by specially trained staff with the requisite skills and knowledge, is a precondition for reliable results. Numerous uncertainties associated with these requirements led to a certain unreliability of the results obtained in earlier studies. Provided that the above requirements are met, the present state of the technological art makes it possible to identify even more subtle damage that can be caused by environmental factors.
 ...
PMID:[Bronchopulmonary diseases and the environment: a generation problem. The environment and pneumology: recognizing damage--damage containment]. 239 33

The fifth leading cause of death in the United States, chronic obstructive respiratory conditions, cannot be cured but can be considerably ameliorated by appropriate management. Many patients with COPD have a combination of chronic bronchitis, asthma, and emphysema. While the damage due to emphysema is permanent, many of the pathophysiologic changes of asthma and bronchitis can be reversed to some extent, and such reversal should be a goal of therapy. Smoking cessation will help the patient more than any other medical treatment. Bronchodilator therapy is best given by inhalation from a metered dose inhaler and on a maintenance basis. Be sure to check inhaler technique. An anticholinergic agent, eg, ipratropium bromide, is probably most effective, but many patients prefer a beta 2-selective adrenergic agent. Xanthines are currently third choice but are very useful to cover nocturnal dyspnea. Corticosteroids are usually only used in acute exacerbations and then only for short courses. If prolonged use is required, however, the inhalation route minimizes side effects to which these patients are particularly prone. Antibiotics are also usually only used in exacerbations, but one can be liberal with them. Use the less expensive broad-spectrum options for ten days. Some clinicians believe that hydration is an effective expectorant. Mucolytic therapy is extensively used outside the United States. The appropriate role of mucolytic therapy in the treatment of bronchitis remains to be more fully explored. Low-flow oxygen is only used in the prevention or treatment of cor pulmonale when the PaO2 is persistently at or below 55, or with a rising hematocrit and right-sided cardiac changes. If used, oxygen is helpful only when given long term for at least 18 h per day, not on a prn basis. Cardiac glycosides are probably of little benefit, but diuretics have an important role in treatment of fluid retention. Pulmonary vasodilator therapy is still experimental, as is almitrine. Prophylaxis with pneumococcal vaccine and annual influenza vaccine is rational but has not been proven to be of value. Exercise and activity should be encouraged for all except those with frank congestive heart failure. The role of "breathing exercises" is currently being reevaluated. Surgery has almost no place in the management of COPD. Anesthesia often results in postoperative complications in this disease. Avoid all sedatives and tranquilizers.
 ...
PMID:Chronic obstructive pulmonary disease. Current concepts and therapeutic approaches. 240 8

Anti-elastase function in sputum sol-phase from patients with alpha 1-proteinase inhibitor (alpha 1PI) deficiency was compared with sol-phase from patients with cigarette smoke-induced bronchitis and emphysema. Both alpha 1PI (2P less than 0.01) and anti-leucoprotease (ALP) (2P less than 0.01) concentrations were lower in sol-phase from the alpha 1PI-deficient group, although alpha 2-macroglobulin (alpha 2M) levels were similar. There was no difference in alpha 1PI function between the two groups, but the inhibitor was only congruent to 30% active. The absolute neutrophil elastase (NE) inhibitory capacity was similar in both groups (median 185 micrograms of NE inhibited/ml of sputum, range 80-480, for the alpha 1PI-deficient group; median 175, range 80-300, for the bronchitic group). A substantial proportion of NE inhibition in secretions could not be accounted for by the amount of alpha 1PI, ALP and alpha 2M present (median 74.8%, range 43.2-97.4, for alpha 1PI-deficient sol-phase; median 50.0%, range 0-80.8, for bronchitic sol-phase). Gel filtration of sol-phase demonstrated the presence of NE inhibition in the low molecular weight fractions which was markedly sensitive to changes in substrate concentration and ionic strength, in contrast to purified alpha 1PI and ALP. Sputum sol-phase from both groups failed to prevent hydrolysis of elastin-fluorescein or succinyltrialanyl-p-nitroanilide by NE completely during prolonged incubation in the presence of an excess of functional inhibitors. This was more apparent in secretions from subjects with alpha 1PI deficiency and may explain why such patients have a more rapidly progressive form of emphysema.
 ...
PMID:Elastase inhibitors in sputum from bronchitic patients with and without alpha 1-proteinase inhibitor deficiency: partial characterization of a hitherto unquantified inhibitor of neutrophil elastase. 244 Jun 36

Neisseria microorganisms (Neisseria lactamica, Neisseria sicca, and Neisseria mucosa) are regarded as normal respiratory commensals. Branhamella catarrhalis (formerly Neisseria catarrhalis) has also been regarded as a normal respiratory commensal, but reports indicate that it can be pathogenic. The role of Neisseria spp was studied in 160 patients with chest infections and symptoms and signs of obstructive respiratory disease. Group I patients (n = 140) had a history of asthma, bronchitis, and emphysema. Group II patients (n = 20) had an initially responsive pulmonary tuberculosis but presented with fever and obstructive airway disease. Group I patients had disease that was difficult to control despite increased bronchodilator therapy, but they responded dramatically after two to three days of appropriate antibiotic therapy. Patients in group II showed a similar response to erythromycin. Neisseria infection was responsible for precipitating or exacerbating respiratory distress in both groups. Accordingly, it is concluded that Neisseria can be pathogenic and that patients with fever and obstructive respiratory symptoms require treatment.
 ...
PMID:Respiratory symptoms due to Branhamella catarrhalis and other Neisseria species infections--response to erythromycin therapy. 250 70

Domiciliary nebulizer use is evaluated in a well-defined population on the Isle of Wight covering all ages. A questionnaire was administered to 167 known users and all were completed. The indication for nebulizer therapy was asthma (137), bronchitis (32) and emphysema (30). Twenty-three had never had a simple inhaler device prescribed and, of the others, 13 had never had instruction in its use. One hundred and fifty-three had used the nebulizer within the previous year and, of these, instruction was provided by physiotherapist (87), general practitioner (30), nurse (19) and hospital doctor (6). Nine received no advice. The drugs used comprised mostly salbutamol (140) and sodium cromoglycate (51). Twenty-six mixed medicines for use in the nebulizer and 24 admitted to exceeding the recommended dose. Twenty-three patients had a peak flow meter available at home. With treatment failure, 108 would call a doctor or report to hospital, while 25 would persist with nebulizer therapy. Thirty-two patients had no help at home in the event of an emergency. Most patients thought that they benefited greatly from nebulizer treatment at home, but better selection of patients and monitoring of treatment is needed. Comparison with previous studies suggests that there has been little improvement in the domiciliary use of nebulizers.
 ...
PMID:The use and misuse of domiciliary nebulizer therapy on the Isle of Wight. 260 58


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>