Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0034067 (emphysema)
 11,506 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Examinations of the lung vessels in diabetes of various degrees of severity and duration revealed changes in the vessels similar to diabetic microangiopathy in other organs (kidneys, skin). Manifestations of diabetic microangiopathy in the lungs are most marked in arterioles and capillaries of the alveolar septae. Diabetic microangiopathy in the lungs is characterized by phenomena of plasmorrhagy and insudation, thickening of capillary basal membranes, sclerosis and hyalinosis of capillary and arteriola walls, and accumulation of alveolar macrophages resorbing metabolism products in alveolar lumen. Diabetic microangiopathy leads to the development of alveolar septae sclerosis and to centrilobular pulmonary emphysema. As compared with the involvement of the vessels in the kidneys and the skin, manifestations of diabetic microangiopathy in the lungs lag in their development and are less manifest.
 ...
PMID:[Morphological changes in the lung blood vessels in diabetes mellitus]. 42 38

Morphological examinations in the lungs in patients with diabetes mellitus of different degrees of severity and duration (28 autopsy observations) were carried out. Diabetic microangiopathy in the lungs was found to involve the capillaries of alveolar septa and arterioles as well as pleural arterioles, and is manifested by plasmorrhagia, insudation, thickening of basal membranes and hyalinosis of the vessels. Moreover, intraseptal nodules, granulomas in small artery walls, focal proteinosis develop in the lungs followed by sclerosis of the microcirculatory bed vessels and centrilobular emphysema. All these comprise a favourable background for the development of pneumonias which, along with pulmonary-cardiac insufficiency are one of the most frequent causes of death of patients with diabetes mellitus.
 ...
PMID:[Changes in the lungs in diabetes mellitus]. 712 37