Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0034067 (
emphysema
)
11,506
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Senescent cells accumulate in tissues during aging and are considered to underlie several aging-associated phenotypes and diseases. We recently reported that the elimination of
p19
ARF
-expressing senescent cells from lung tissue restored tissue function and gene expression in middle-aged (12-month-old) mice. The aging of lung tissue increases the risk of pulmonary diseases such as
emphysema
, and cellular senescence is accelerated in
emphysema
patients. However, there is currently no direct evidence to show that cellular senescence promotes the pathology of
emphysema
, and the involvement of senescence in the development of this disease has yet to be clarified. We herein demonstrated that
p19
ARF
facilitated the development of pulmonary
emphysema
in mice. The elimination of
p19
ARF
-expressing cells prevented lung tissue from elastase-induced lung dysfunction. These effects appeared to depend on reduced pulmonary inflammation, which is enhanced after elastase stimulation. Furthermore, the administration of a senolytic drug that selectively kills senescent cells attenuated
emphysema
-associated pathologies. These results strongly suggest the potential of senescent cells as therapeutic/preventive targets for pulmonary
emphysema
.
...
PMID:Elimination of p19
ARF
-expressing cells protects against pulmonary emphysema in mice. 3005 37
