Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034067 (emphysema)
 11,506 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Eleven female rabbits, mainly of the NZW breed, aged between 1 and 3.5 years, were examined post mortem. All had originated over the years 1982 to 1987 from the same rabbitry where they had been fed on pellets from the same manufacturer. Apart from one rabbit, all had a history of progressive loss of bodily condition and six of them had also been infertile. Grossly, most of them were emaciated and their arteries were hardened. In some, hepatopathy, nephropathy and pulmonary emphysema were evident. In one case, mummified foetuses were recovered from the abdominal cavity. Microscopically, degenerative changes and calcification were found in the walls of arteries, kidneys, lungs, hearts and ovaries.
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PMID:Arteriosclerosis and related lesions in rabbits. 258 47

Pulmonary emphysema is an extraordinarily prevalent disease, especially among men, and is found in about 40% of all autopsies at this Veterans Medical Center. However, in the great majority of cases, it is an incidental finding, and the individual has died of another lesion, either pulmonary or in another organ system. These facts have permitted the authors to examine the interrelationships between presence or absence of emphysema and the cause of death in a consecutive series of 1033 autopsies. Results show that chronic renal disease is much less common as a cause of death in persons with, than in those without, emphysema. Since emphysema is closely associated with smoking, the data also show a reduction in risk of death from renal disease in smokers. These trends persist, even when individuals who have died from smoking-related diseases are eliminated from the population. Further analyses suggest that it is the presence of emphysema which is mainly responsible for this effect. A likely mechanism for it is proposed.
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PMID:Lower incidence of death from chronic renal disease in patients with nonlethal emphysema: a statistical study. 323 91

The effectiveness of N-acetyl-L-alanyl-L-alanyl-L-prolyl-L-alanine chloromethylketone (AAPACK) in preventing the development of experimental emphysema in hamsters, when administered 60 min after exposure to elastase, was studied. When 19 mg of AAPACK was injected intraperitoneally in divided doses commencing 60 min after the intratracheal instillation of pancreatic elastase, the development of emphysema was not prevented using morphologic, morphometric, and physiologic means of evaluation. Thirty-eight per cent of hamsters given AAPACK became ill and lost weight. At autopsy, these hamsters had a renal tubular nephropathy and focal interstitial disease. The glomeruli were spared. Five of these hamsters with renal tubular lesions had azotemia. Focal necrosis was observed in the heart of 3 and in the liver of 5 animals with renal lesions. These studies indicated that AAPACK, in the protocol followed where elastase precedes administration of the inhibitor, (1) does not prevent the development of elastase-induced emphysema, and (2) does produce a unique renal tubular nephropathy.
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PMID:Effects of oligopeptide chloromethylketone administered after elastase: renal toxicity and lack of prevention of experimental emphysema. 691 47

Lead, cadmium, mercury and arsenic are widely dispersed in the environment. Adults are primarily exposed to these contaminants in the workplace. Children may be exposed to toxic metals from numerous sources, including contaminated air, water, soil and food. The chronic toxic effects of lead include anemia, neuropathy, chronic renal disease and reproductive impairment. Lead is a carcinogen in three animal species. Cadmium causes emphysema, chronic renal disease, cancer of the prostate and possibly of the lung. Inorganic mercury causes gingivitis, stomatitis, neurologic impairment and nephrosis, while organic mercurials cause sensory neuropathy, ataxia, dysarthria and blindness. Arsenic causes dermatitis, skin cancer, sensory neuropathy, cirrhosis, angiosarcoma of the liver, lung cancer and possibly lymphatic cancer.
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PMID:Occupational and community exposures to toxic metals: lead, cadmium, mercury and arsenic. 716 33

We measured the mean capillary tuft area by a custom-built semi-automatic technique in postmortem sections from the kidneys of 16 patients with "blue and bloated" chronic bronchitis and emphysema and in seven patients of similar age who were free of respiratory and renal disease at death. Nine bronchitic patients had received domiciliary oxygen treatment while seven had not. The mean glomerular tuft area in these treated bronchitic patients (14 200 microns2) was not significantly different from that of the untreated patients (16 900 microns2) but the tuft area in the bronchitic subjects was significantly larger than that of the non-bronchitic controls (12 100 microns2, p less than 0 . 02). There was no reduction in glomerular cellularity to suggest passive venous distension, and glomerular size was not correlated with clinical or pathological indices of cor pulmonale (including red cell mass). The arterial oxygen tension (Po2), however, was correlated with glomerular size (r = 0 . 68, p less than 0 . 01) if allowance was made for the higher Po2 of the patients receiving oxygen. The percentage of glomeruli with an identifiable juxtaglomerular apparatus also increased with increasing glomerular size. These structural changes in the kidneys of patients with severe chronic bronchitis and emphysema may reflect changes in renal salt and water handling that are potentially reversible by oxygen treatment.
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PMID:The renal glomerulus in hypoxic cor pulmonale. 717 90

As of April 30, 1980, 83 nosocomial cases of sporadic legionellosis had been reported to the Centers for Disease Control (CDC). In all 83 cases the patients had pneumonia; the median age of the patients was 56.5 years. All but one patient were hospitalized at the time of onset. Of 71 patients for whom the outcome is known, 22 (31 percent) died of causes directly attributed to their infection. Eleven patients had end-stage renal disease, 28 were receiving systemic immunosuppressive medications, 17 had cancer, 12 had chronic bronchitis or emphysema, 29 were smokers, and four had diabetes mellitus. Risks of acquiring nosocomial sporadic legionellosis for patients with these conditions relative to the general United States population = 340, 26, 11, 3.7, 1.9 and 1.3, respectively. These risk factors are similar to those identified for sporadic community-acquired legionellosis and for epidemic nosocomial legionellosis. Methods for preventing nosocomial legionellosis are not known, but comparing Legionella to other water-associated organisms which have been spread from medical devices to cause pneumonia may be fruitful.
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PMID:Sporadic and epidemic nosocomial legionellosis in the United States. Epidemiologic features. 721 4

As of 30 September 1979, 1005 confirmed cases of sporadic legionellosis caused by Legionella pneumophila serogroups 1 to 4 in U.S. residents had been reported to the Centers for Disease Control; 19% were fatal. All but 2% of the 1005 cases were associated with pneumonia documented by chest radiograph. About 75% of the cases occurred in June through October. The risk of acquiring sporadic legionellosis was increased among males and persons 50 years or older; persons with renal disease necessitating dialysis or transplantation, with chronic bronchitis or emphysema, with diabetes mellitus, and with cancer (10 selected sites or types); persons who smoke; and persons being treated with immunosuppressive drugs. Increasing age and chronic bronchitis or emphysema were associated with increased risk of death. The sensitivity of culturing L. pneumophila from specimens positive by direct immunofluorescence was estimated to be 45%. The distribution of serogroups 1, 2, 3, and 4 of L. pneumophila in 57 fresh, not previously examined direct fluorescent antibody-positive specimens was 84%, 11%, 4%, and 2%, respectively; all 26 strains isolated from these specimens were of one of these four serogroups.
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PMID:Sporadic legionellosis in the United States: the first thousand cases. 746 7

The association between deficiency of alpha-1-antitrypsin (A1AT) and glomerulonephritis has been only sporadically reported on, as opposed to the linkage between A1AT-deficiency and lung emphysema or hepatic cirrhosis. We describe the case of a 30-year-old man with A1AT deficiency who developed hepatic cirrhosis in early childhood, and IgA glomerulonephritis and hypertension in adult life. The IgA nephritis followed an unusual course. After three years of slight elevation of serum creatinine levels, the patient rapidly developed renal failure necessitating acute hemodialysis. The deterioration of the renal function was preceded by eruption of skin lesions, believed to represent a vasculitis. After six months of hemodialysis, the patient successfully received a transplanted kidney from his mother. The literature is reviewed with respect to the association between A1AT-deficiency and renal disease. We discuss possible underlying causes for the rapid deterioration of renal function in this patient.
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PMID:[Alpha 1-antitrypsin deficiency--not only pulmonary and hepatic involvement]. 770 89

We have reviewed our experience in the management of myeloma patients who present with features of severe renal impairment, to examine the role of intensive treatment of the renal failure, and to assess the role of renal biopsy. Between March 1983 and August 1991, 16 patients, who were subsequently diagnosed as having myeloma, presented to the Department of Renal Medicine for investigation of renal failure; nine with symptoms of uraemia and seven with pneumonia, bone pain, emphysema, or ischaemic heart disease. Renal biopsy was performed on 14 patients. Eleven patients had myeloma cast nephropathy, two of whom had concurrent hypertensive nephropathy, two patients had light chain deposition disease, and one patient had interstitial nephritis. Renal function improved in six patients with aggressive rehydration, but three of them subsequently required dialysis. In all 11 patients required dialysis, two short-term and nine long-term. Seven patients were given conventional melphalan and prednisolone and nine patients received VAMP as induction cytotoxic chemotherapy. Five of the VAMP sub-group received interferon alpha 2b as maintenance therapy. The median renal survival was five months (range 0-36 months) and median overall survival was 20 months (range 1-54 months). We conclude that intensive treatment, including dialysis, in myeloma patients with renal failure may result in survival durations approaching those of unselected myeloma patients, and a significant proportion will enjoy a reasonable quality of life.
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PMID:Intensive treatment of renal failure in patients with myeloma. 773 18

An association of alpha 1-antitrypsin deficiency with glomerulonephritis is rare and has so far been observed only in children or young adults. We report a 63-year-old man with severe alpha 1-antitrypsin deficiency associated with pulmonary emphysema, cirrhosis of the liver, and mesangioproliferative glomerulonephritis with nephrotic syndrome. Following initial presentation with nephropathy, further work-up revealed alpha 1-antitrypsin deficiency of proteinase inhibitor Z. In the absence of glomerular alpha 1-antitrypsin deposits the relationship between renal disease and alpha 1-antitrypsin deficiency remains unclear. alpha 1-Antitrypsin deficiency should be considered in adults with abnormal renal function and chronic liver disease.
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PMID:Glomerulonephritis as late manifestation of severe alpha 1-antitrypsin deficiency. 808 78


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