Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034067 (emphysema)
 11,506 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The health effects of human exposure to cadmium are discussed with emphases on intake, absorption, body burden, and excretion; osteomalacia in Japan; hypertension; and proteinuria, emphysema, osteomalacia, and cancer in workers. Elevated blood pressure has not been observed as a result of excessive exposures to cadmium in Japan or the workplace. Renal tubular dysfunction and consequent proteinuria is generally accepted as the main effect following long-term, low-level exposure to cadmium. Studies of workers show that proteinuria may develop after the first year of exposure or many years after the last exposure. Proteinuria and deterioration of renal function may continue even after cessation of exposure. The immediate health significance of low-level proteinuria is still under debate. However, there is evidence that long-term renal tubular dysfunction may lead to abnormalities of calcium metabolism and osteomalacia. The few autopsy and cross-sectional studies of workers do not permit conclusions to be drawn regarding the relationship between cadmium exposure and emphysema. Retrospective and historical-prospective studies are needed to settle this important question. No conclusive evidence has been published regarding cadmium-induced cancer in humans. However, there is sufficient evidence to regard cadmium as a suspect renal and prostate carcinogen. Because of equivocal results and the absence of dose-response relationships, the studies reviewed should be used with caution in making regulatory decisions and low-dose risk assessments.
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PMID:Human health effects of exposure to cadmium. 352 15

Prevalence of medical disorders was determined for 10,758 consecutive admissions for inpatient alcoholism treatment to 13 hospitals located in eight states of the United States. The majority of patients (approximately 70% of the men and 73% of the women) had a significant medical problem other than alcoholism. The most prevalent disorders were diseases of the liver, gallbladder and pancreas; bronchitis; emphysema; and asthma. Hypertensive disease was found in 15% of the men and 7% of the women. Psychiatric disorders associated with alcoholism were neuroses, personality disorders and other nonpsychotic states. Less than 10% of all patients were referred by physicians; more than 90% had not been previously diagnosed or treated for medical or psychiatric disorders associated with alcoholism. The high prevalence of medical disorders indicates that inpatient treatment of alcoholism should be undertaken in facilities that have expertise and resources for concurrent treatment of serious medical illness.
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PMID:Alcoholism and prevalence of medical and psychiatric disorders. 376 58

The nerve density, expressed as total length of nerve fibers per square millimeter of tissue section, was measured in both carotid bodies from five subjects free from cardiopulmonary disease and from eight subjects with carotid body hyperplasia. Six of the cases with enlargement of the carotid body had been exposed to chronic hypoxemia in life (due to panacinar pulmonary emphysema in five instances and the pickwickian syndrome in one case), and the other two cases had had systemic hypertension. The cases of carotid body hyperplasia showed an increased nerve density associated with the characteristic proliferation of elongated cells. These findings confirm that the proliferating cells in carotid body hyperplasia are both sustentacular and Schwann's cells, not fibroblasts, and suggest that these cells develop to support an increased number of nerve axons. The mechanisms by which two such different stimuli as chronic hypoxemia and raised intravascular pressure bring about an increased nerve density are obscure.
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PMID:Nerve axons in carotid body hyperplasia. A quantitative study. 383 53

A patient with severe closed head injury and tension subcutaneous emphysema developed intracranial hypertension unresponsive to conventional treatment. Subcutaneous air drainage controlled the intracranial pressure. The subcutaneous pressure was directly correlated with intracranial pressure.
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PMID:Intracranial hypertension secondary to tension subcutaneous emphysema. 383 28

The histories of 117 patients with left axis deviation and complete right bundle branch block (rbbb) on the electrocardiogram were reviewed for evidence of clinical cardiac disease, hypertension or emphysema. One hundred fifty-four patients with complete right bundle branch block alone served as controls. The incidence of coronary artery disease (myocardial infarction or angina) was significantly greater in the group with pronounced left axis deviation; the other factors evaluated showed no significant difference between the two groups. Pronounced left axis deviation of the mean qrs axis is associated with a high prevalence of clinical coronary artery disease. The presence of complete right bundle branch block does not alter their relationship. Some patients with complete rbbb, or with rbbb and pronounced left axis deviation, have no clinical evidence of heart disease.
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PMID:The significance of pronounced left axis deviation in the presence of right bundle branch block. 577 97

The histopathology of hyperplasia of the carotid bodies was studied in 6 cases of hypoxaemia and right ventricular hypertrophy secondary to pan-acinar emphysema, and in five cases of systemic hypertension with left ventricular hypertrophy. The features of the hyperplasia were the same in the two groups. There was proliferation of sustentacular (type II) cells and compression of central cores of chief (type I) cells. It is speculated that the hyperplasia of sustentacular cells is associated in some way with the prevention of retention of sodium ions and water which characterises hypoxic cor pulmonale in "blue bloaters", systemic hypertension, and ascent to high altitude with the complications of acute mountain sickness, and pulmonary and cerebral oedema.
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PMID:Hyperplasia of the carotid body. 621 75

The histopathology of the enlarged carotid bodies, in both qualitative and quantitative terms, is described in two cases. One was in a woman of 80 years with systemic hypertension and the other in a man of 72 years with pan-acinar emphysema complicated by chronic hypoxaemia. In both instances there was generalized hyperplasia of sustentacular cells, perhaps with involvement of Schwann cells and fibrocytes, with superimposed focal proliferation of dark or 'pyknotic' variants of chief cells. The functional significance of both froms of tissue response in the carotid bodies is speculated upon.
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PMID:Dark cell proliferation in carotid body hyperplasia. 623 Apr 24

The health effects of human exposure to cadmium are discussed with emphasis on intake, absorption, body burden, and excretion; osteomalacia in Japan; hypertension; and proteinuria, emphysema, osteomalacia, and cancer in workers. Elevated blood pressure has not been observed as a result of excessive exposures to cadmium in Japan or the workplace. Renal tubular dysfunction and consequent proteinuria is generally accepted as the main effect following long-term, low-level exposure to cadmium. Studies of workers show that proteinuria may develop after the first year of exposure or many years after the last exposure. Proteinuria and deterioration of renal function may continue even after cessation of exposure. The immediate health significance of low-level proteinuria is still under debate. However, there is evidence that long-term renal tubular dysfunction may lead to abnormalities of calcium metabolism and osteomalacia. The few autopsy and cross-sectional studies of workers do not permit conclusions to be drawn regarding the relationship between cadmium exposure and emphysema. Retrospective and historical-prospective studies are needed to settle this important question. No conclusive evidence has been published regarding cadmium-induced cancer in humans. However, there is sufficient evidence to regard cadmium as a suspect renal and prostate carcinogen. Because of equivocal results and the absence of dose-response relationships, the studies reviewed should be used with caution in making regulatory decisions and low-dose risk assessments.
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PMID:Human health effects of exposure to cadmium. 636 79

Sixty-seven bronchoscopic examinations were performed in a busy surgical intensive care unit on 51 patients, and the techniques, morbidity, and outcome were prospectively analyzed to assess the efficacy and safety of the procedure in this particular patient population. General surgical trauma, cardiothoracic, and orthopedic patients were included. Fifty-three (79%) procedures were performed with the flexible instrument, while 14 patients (21%) underwent rigid endoscopy. Forty-six patients were being mechanically ventilated; 30 had endotracheal tubes, and 16 had tracheostomies. Suspected lobar collapse (60%), persistent pulmonary infiltrates (3%), suspected aspiration (21%), and suspicion of airway trauma (12%) were the primary clinical indications for bronchoscopy. No deaths occurred. Complications were seen in 16 per cent of the procedures and 17 per cent of the patients. There were arrhythmias (other than sinus tachycardia) in seven procedures (11%) and one episode each of hypertension, self-limited endobronchial bleeding, mediastinal emphysema, and increased intracranial pressure. Significant improvement was demonstrated for patients with lobar collapse but not for those with mild atelectasis or pulmonary infiltrates on radiographs taken within 24 hours. Overall, 39 patients (58%) improved radiographically, while 38 patients (42%) did not. Differences in arterial PO2 measured before and after bronchoscopy between groups ventilated with an FiO2 of 1.0, and those who were not did not achieve statistical significance (P less than 0.05).
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PMID:Bronchoscopy in the critically ill surgical patient. 646 91

Pulmonary artery pressures were estimated by an indirect method using echocardiography (Boyd et al. 1980), in a group of patients with chronic airflow obstruction, in order to investigate the degree of pulmonary hypertension in patients with emphysema. We found a positive correlation between the estimated pulmonary artery end diastolic pressure (PAEDP) and the radiological emphysema score (r = 0.58, P less than 0.005), and between the estimated PAEDP and the transfer constant for carbon monoxide (KCO) (r = 0.66, P less than 0.002). There was no correlation between the PAEDP and the arterial partial pressure of oxygen (PaO2) before exercise, between the PAEDP and the change in oxygen partial pressure after exercise, or between the KCO and the PaO2. It is suggested that emphysema does predispose to pulmonary arterial hypertension and that the relationship is probably secondary to vessel destruction rather than hypoxia.
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PMID:Pulmonary arterial hypertension and emphysema. 674 18


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