Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0034067 (emphysema)
 11,506 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Giant emphysema of a lung lobe has distinctive features. Classically there is overdistension of the affected lung lobe, with one lobe only being involved, and, 50% of cases occur in the newborn infant [1, 4, 8]. The authors describe a particularly severe example with marked mediastinal shift and initially the hemithorax on the side of the lesion was opaque. Angiography was carried out and followed by resection when the infant was 4 months old.
 ...
PMID:Giant lobar emphysema--neonatal diagnosis. 51 84

Giant compressive bullous emphysema is rare. The three major considerations for operation involve a breathless patient with giant bullae occupying more than one-third of one lung field who has a positive pulmonary arteriogram revealing diminished blood flow to the involved lung. Finally, we think that the survivors in our series, eight long-term postoperative patients alive one year to 14 years, supply gratifying evidence that surgery can provide effective and safe palliation.
 ...
PMID:Effective surgical palliation of giant compressive bullous emphysema (vanishing lung syndrome): long-term follow-up. 125 50

To investigate the influence of smoking on the aging immune system, the following parameters were determined in elderly smokers and non-smokers: presence of emphysema; absolute number of leucocytes, lymphocytes, T cells and B cells bearing membrane-bound IgG; serum IgG, IgA, IgM levels, occurrence of rheumatoid and antinuclear factors, and natural antibody level (against different bacteria). Ultrastructural disorders in lymphocytes were also investigated. The number of leucocytes, the levels of serum IgA, and the prevalence of autoantibodies were higher, and the natural antibody level was lower in smokers than in non-smokers. Giant mitochondria and cytoplasmic disorders were found more frequently in smokers than in non-smokers, and in an even higher rate in smokers with emphysema. These findings suggest that smoking may accelerate the appearance of age-dependent (especially disease-related) immunological changes.
 ...
PMID:The effect of smoking on peripheral blood lymphocytes and on some immunological parameters in old age. 239 75

Giant bullous emphysema often has serious dyspnea, and is difficult to manage. Bullectomy through thoracotomy for this disease carries a substantial morbidity and mortality. The aim of this report is to investigate the feasibility and key techniques of video-assisted thoracoscopic bullectomy for giant bullous emphysema. From December 1995 to October 1996, 6 patients with giant bullous emphysema underwent bullectomy by means of video-assisted thoracoscopy. Giant bullae occupied at least 50% of hemithorax, and 4 of which occupied more than 90%. According to Hugh-Jones dyspnea criteria: grade II in 3 cases, grade III in 2 and grade IV in 1, four bullectomies were done by video-assisted theracoscopy alone. One bullectomy and one left pneumonectomy were performed by combination of theracoscopy and a 8 cm thoracic incision. All procedures were accomplished successfully. The operating time ranged from 65 to 150 minutes. There was no blood transfusion and perioperative complications. Lung function was significantly improved in all patients after surgery (all better than grade II). Thoracoscopic bullectomy for giant bullous emphysema is a technically feasible and safety procedure, especially for group I and group II patients. However, there are still many problems to be resolved in thoracoscopy for group III and IV giant bullous emphysema.
 ...
PMID:[Video-assisted thoracoscopic bullectomy for giant bullous emphysema]. 1067 29

Giant pulmonary cyst is a rare clinico-pathological entity. It was described as a "windy tumor" by John Floyer in 1726. Since that time, there have been numerous reports on this unique manifestation of emphysema by many authors. In this report, we report one such interesting case who was diagnosed as tension pneumothorax.
 ...
PMID:Giant pulmonary cyst simulating tension pneumothorax. 1146 70

Giant bullae can be complicated by respiratory tract infection in the setting of emphysema. Herein we describe a technique of palliative decompression of the bullae that gives time to treat acute pulmonary infection prior to definitive surgical treatment.
 ...
PMID:Decompression of giant bulla in acute pneumonia: surgical palliation prior to definitive management. 1772 Apr 53

Giant paraesophageal hernia is an uncommon morbid disorder which may present a risk of catastrophic complications and should be repaired electively as soon as possible. Laparoscopic fundoplication is the mainstay of surgical management of this disorder due to several advantages such as lower post-operative morbidity and pain. We report a case of a 70-year-old patient with a giant paraesophageal hernia, who developed subcutaneous emphysema with pneumothorax during laparoscopic fundoplication. Early diagnosis was possible by close clinical evaluation and simultaneous monitoring of end-tidal carbon dioxide levels and airway pressures. Although positive end-expiratory pressure application is an effective way of managing pneumothorax secondary to the passage of gas into the interpleural space, insertion of an intercostal drain may be used in an emergent situation.
 ...
PMID:Pneumothorax during laparoscopic repair of giant paraesophageal hernia. 2189 11

Giant bullae may be found in association with emphysema. They present as pockets of entrapped air which grow as the surrounding lung retracts away. As they do not take part in gas exchange and merely occupy space, their presence leads to severe impediment of mechanical ventilation in the adjacent lung parenchyma. Patients may present with dyspnoea, exercise intolerance and a feeling of pressure in the chest. The case of a 54 year old gentleman is presented, who was found to have a giant bulla occupying his left hemithorax on a routine chest X-ray. The patient remained asymptomatic despite the large size of the bulla and was treated with surgical resection via thoracotomy i.e. Bullectomy which is the treatment of choice. If left untreated the condition can be complicated by pneumothorax, infection and a slow progression to malignant changes.
 ...
PMID:Asymptomatic presentation of giant bulla of the left apical and anterior segment of the left upper lobe of the lung with near complete atelectasis of the remaining left lung. 2275 81

Chronic obstructive pulmonary disease (COPD) is a common and morbid progressive disease where treatment is focused on improving dyspnea, reducing exacerbations, attenuating comorbidities, and improving quality of life. Surgical therapy can be beneficial to a carefully selected subset of individuals and is the subject of this review. The National Emphysema Treatment Trial (NETT) has not only demonstrated the efficacy of lung volume reduction surgery (LVRS) but has also provided many lessons regarding advanced emphysema. NETT demonstrated that LVRS improves exercise performance, quality of life, and pulmonary function in those with upper lobe predominant emphysema in the setting of advanced disease. Those with upper lobe predominant emphysema and low exercise tolerance also had a survival advantage compared with maximal medical therapy. Careful patient selection is paramount to success, as there clearly are patients in whom LVRS increases mortality. Giant bullae are rare, but bullectomy has been demonstrated to improve dyspnea and lung function in cases where the bulla occupies at least one-third of the hemithorax and compresses some adjacent lung tissue. For patients with chronic respiratory failure due to COPD who have not improved despite maximal surgical and medical therapy, lung transplantation remains an option in those without significant comorbid conditions.
...
PMID:Surgical Approaches to Treating Emphysema: Lung Volume Reduction Surgery, Bullectomy, and Lung Transplantation. 2623 44

Giant congenital lobar emphysema is a rare pathological malformation in infants. Authors report a similar case that is remarkable for its even rarer segmental location and compressive character. The patient underwent successful urgent segmentectomy for the treatment of respiratory distress in a developing country.
...
PMID:[Giant congenital compressive segmental emphysema: diagnosis and treatment]. 2730 89


1 2 Next >>