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Query: UMLS:C0034065 (pulmonary embolism)
 14,979 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Platelet plays an important role in thromboembolic diseases. It is demonstrated that recurrent pulmonary embolism may cause pulmonary hypertention. In recent years, P-selectin (granule membrane protein, GMP140) was found to be a surface marker for platelet activation. In order to investigate the role of platelet in chronic cor pulmonale, the changes of P-selectin on platelet membrane and its effect on platelet adhesiveness (PAdT) and platelet aggregation (PAgT) were studied. The results showed that the changes of P-selectin PAdT and PAgT in chronic cor pulmonale were significant than those in chronic pulmonary diseases and controls (P < 0.01). There was positive correlation between P-selectin and PAdT (r = 0.6831, P < 0.01) as well as PAgT (r = 0.7142, P < 0.01). The levels of von Willebrand factor (vWF) and fibrinogen (Fg) were markedly increased in chronic cor pulmonale as compared with chronic pulmonary disease and control group (P < 0.01). There was also positive correlation between vWF and PAgT (r = 0.4143, P < 0.05) as well as between Fg and PAgT (r = 0.4392, P < 0.05). It is concluded that platelet plays an important role in the pathogenesis of chronic cor pulmonale.
Zhonghua Nei Ke Za Zhi 1995 Jan
PMID:[The relationship between P-selectin on platelet membrane and platelet function in chronic cor pulmonale]. 754 26

We reported 25 cases of patients with pulmonary embolism (PE) definitely diagnosed in our hospital from 1983 to 1990. Twenty-one cases of them were found in the last 5 years. This indicated that the discovery rate had increased obviously. Five of these patients were confirmed by autopsy, the other twenty cases were diagnosed by clinical manifestations combined with perfusion-inspiration lung scans and chest roentgenogram. Due to the prompt diagnosis and the appropriate use of anticoagulants, 72% of the patients survived after treatment. We suggest that all the patients with suspected PE should take perfusion-inspiration lung scans, because this is a noninvasive and reliable method. Digital subtraction angiography is necessary for some patients. Routine chest radiography, arterial blood gas analysis, intrapulmonary shunt test, deep venography or nuclide scan of lower extremities are also useful methods for the diagnosis of PE.
Zhonghua Nei Ke Za Zhi 1993 Sep
PMID:[Pulmonary embolism: an analysis of 25 patients]. 811 38

To improve the identification of chronic thromboembolic pulmonary hypertension. We restrospectively analysed clinical data of 72 patients with chronic thromboembolic pulmonary hypertension (CTEPH). The levels of arterial blood gases appeared to be decrease in PaO2 and PaCO2, and increase in P(A-a)O2. There were 80.3% of unsymmetrical pulmonary hyperlucencies on chest radiograph and 76.4% of right ventricular hypertrophy on electrocardiograph, 92.5% and 97.1% of right atrial and right ventricular enlargement, respectively. 11.1% of pericardial effusion was noted on echocardiograph, and 98.5% of rise in pulmonary arterial pressure calculated by Doppler. The mean pulmonary arterial pressure was 6.50 +/- 1.80 kPa (48.75 +/- 13.50 mmHg), in part, by right cardiac catheterazation. Both the incidences of pulmonary embolism were 100.0% on pulmonary angiography and on radionuclide lung perfusion scan. There were 43.1% of the history of deep venous disorders and 75.0% of the positive findings by radionuclide venography in the lower extremities, respectively. The misdiagnostic and the lost diagnosis rate of prehospitalization accounted for 90.3%. The understanding of clinical manifestations and laboratory findings of CTEPH is important to promote diagnostic sense and level of CTEPH.
Zhonghua Nei Ke Za Zhi 1997 May
PMID:[Clinical analysis in seventy-two patients with chronic thromboembolic pulmonary hypertension]. 1037 75