Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0034065 (
pulmonary embolism
)
14,979
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We recently found that
thymidine phosphorylase
(
TYMP
), also known as platelet-derived endothelial cell growth factor, plays an important role in platelet activation in vitro and thrombosis in vivo by participating in multiple signaling pathways. Platelets are a major source of
TYMP
. Since platelet-mediated clot formation is a key event in several fatal diseases, such as myocardial infarction, stroke and
pulmonary embolism
, understanding
TYMP
in depth may lead to uncovering novel mechanisms in the development of cardiovascular diseases. Targeting
TYMP
may become a novel therapeutic for cardiovascular disorders. In this review article, we summarize the discovery of
TYMP
and the potential molecular mechanisms of
TYMP
involved in the development of various diseases, especially cardiovascular diseases. We also offer insights regarding future studies exploring the role of
TYMP
in the development of cardiovascular disease as well as in therapy.
...
PMID:Thymidine phosphorylase: A potential new target for treating cardiovascular disease. 2926 86
