Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0034065 (pulmonary embolism)
 14,979 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Experience with laparoscopic tubal sterilization by electrocoagulation alone or in addition to induced abortion in 300 patients is reported. Abortion was performed in 150 patients, either by vacuum aspiration (98%) or by intravenous infusion of prostaglandin F2alpha. Operation time for tubal ligation alone averaged about 40 minutes; for tubal sterilization and abortion, about 50 minutes. Patients undergoing sterilization alone could be released from the hospital after 1-2 days while abortion patients were hospitalized longer. In 16 cases other operations were also performed on the basis of laparoscopic findings. Complications included hemorrhage (6 cases) and possible pulmonary embolism (1 case). Pregnancy occurred in 1 patient about 5 months after operation and was apparently due to operator error, since no evidence of scar tissue could be found on the intact left tube.
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PMID:[Tubal ligation by laparoscopy: alone and as an additional operation (author's transl)]. 427 12

(PGF2alpha) Prostaglandin F2alpha was administered intraamniotically to 16 patients in 3 groups: molar pregnancy (8 cases), fetal death (6 cases), and anencephalic fetus (2 cases). These particular types of situations were selected because the effects of PGs upon the product were unknown. PG was administered in dosages between 3 and 200 mcg after being prepared in an ethanol solution. It appeared to have no effect on uterine contractility. It is best to start contractility stimulation with low doses which should be increased progressively according to uterine response. Tone, intensity, frequency, and uterine activity increased when PG dose was increased. Uterine labor as to maturity and cervical dilatation, was studied in the 3 groups. Blood pressure was registered in 2 patients with molar pregnancy; there were no changes during the 1st hours of the study. However, during the last part, differential pressure increased by systolic increase. In 4 patients with fetal death, cervical dilatation register was taken. Average dilatation time (going from 2-10 cm) was 9.50 hours. There were such side effects as slight nausea, vomiting, and chills. 1 of the patients presented with hypotension upon administration of PGF2alpha 200 mcg. 4 patients suffered complications; 1 with molar pregnancy had a possible pulmonary embolism by trophoblast, another had hemorrhage and hypotension, 1 patient with fetal death had immediate hypotension after administration of 200 mcg, and the other had deciduo-myometritis which cleared with antibiotics and curettage. No other subjects experienced complications. Intraamniotic PG administration produced few side effects. (author's modified)
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PMID:[Effect of prostaglandin F2a on the contractility of the pregnant human uterus]. 441 23