Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034065 (pulmonary embolism)
 14,979 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The diagnostic modes and results of treatment 7 patients with periappendicular abscess, complicated by the acute short-bowel obstruction are discussed. Age varied from 19 to 76 years. 4 of them were hospitalized with ileus symptoms, the rest 5 developed the obstruction during the hospital stay. 2 patients had an urgent operation, 4 patients were operated after 2-4 days and 1 after 9 days after admission. The correlation between the obstruction symptoms and appendicular inflammation was supposed in 3 patients. The cause of small-bowel obstruction was twist of the intestine loop, matted to the appendicular abscess. The surgery consisted of abscess sanation, appendectomy, small-bowel decompression and extrication. One patients died postoperatively of pulmonary embolism.
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PMID:[The acute small-bowel obstruction caused by periappendicular abscess]. 1883 62

We present the case of a 17-year-old girl who suddenly woke up with localized pain in the left groin and the inability to twist her leg. After comprehensive physician and laboratory examinations, deep venous thrombosis with consequent pulmonary embolism was ascertained. She had not experienced any recent trauma, but she had started to take oral contraceptives 6 months prior to the onset of the symptoms. Her parents and sisters had been asymptomatic throughout their lives, but the family history revealed a few thromboembolic accidents. Using DNA analysis, heterozygosity for factor V Leiden, prothrombin gene mutation G20210A and methylenetetrahydrofolate reductase C677T, as well as the homozygous 4G/4G genotype in the plasminogen activator inhibitor 1 were identified in our patient. Subsequently, DNA analysis was performed in all living family members, and multiple factors associated with thrombophilia were discovered. Our case confirms the multifactorial cause of thromboembolic events and emphasizes the importance of oral contraceptive use in the onset of venous thrombosis, especially in teenage females. In addition, this case indicates that teenage females with a family history of thrombosis who are making choices about contraception could most likely benefit from advanced thrombophilia testing.
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PMID:Contraception-related deep venous thrombosis and pulmonary embolism in a 17-Year-old girl heterozygous for factor V leiden, prothrombin G20210A mutation, MTHFR C677T and homozygous for PAI-1 mutation: report of a family with multiple genetic risk factors and review of the literature. 2066 90