Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034065 (pulmonary embolism)
 14,979 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 69-year-old man presented with cough, shortness of breath, and fatigue. He was initially treated for allergies and then for pulmonary embolism. Radiologically, a tumor mass was found to occlude the right pulmonary artery and involve the pulmonary trunk. A right pneumonectomy was performed. Histologically, a cellular malignant spindle and epithelioid tumor with areas of necrosis and brisk mitotic activity was seen. In some areas, the tumor appeared to form vascular channels. Focal osteosarcomatous differentiation was present. Immunohistochemical studies were performed including vimentin, smooth muscle actin, desmin, CD31, CD34, S100, and pan-cytokeratin. The tumor cells were positive for CD31 and vimentin and negative for pan-cytokeratin, CD34, and S100. Two months after surgery, the patient was alive and well.
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PMID:Pulmonary artery angiosarcoma: a clinicopathologic and radiological correlation. 1608 54

A 54-year-old woman complained of dyspnea, due to complete obstruction of the left main bronchus caused by recurrent esophageal carcinoma, was transferred to our department about two months after curative resection (with preoperative chemotherapy for T4 cancer) in July 2004. She suddenly developed a severe shortness of breath with anxiety, and arterial blood gas analysis revealed a PaO2 of 25 mmHg (FiO2 1.0). The presence of pulmonary embolism was diagnosed by pulmonary perfusion scintigraphy. Thrombolytic therapy with urokinase was started to keep the air way. Fogarty catheter and bronchoscopic Nd-YAG laser treatment was performed. After that, an expandable metallic stent (EMS) was placed at the site of obstruction without any troubles, and there was a striking improvement in her condition of respiration and atelectasis. The radiation therapy was initiated and completed safely. The tumor lesion had disappeared on CT scan after the radiation therapy (a total dose of 50 Gy). We experienced a case that could be rescued from an advanced respiratory failure caused by one side air way obstruction and another side's blood circulation disorder.
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PMID:[A case report of complete obstruction of the left main bronchus caused by recurrent esophageal carcinoma with pulmonary embolism of right lung after surgery for esophageal cancer]. 1631 25

Dyspnea is an alarming symptom for both the patient and the emergency physician. There are many causes of dyspnea, some of which are life-threatening, especially in the elderly patient. In addition to the usual cardiac and pulmonary causes such as congestive heart failure, asthma exacerbation, COPD, pneumonia, and pulmonary embolism, there are less common causes of dyspnea, which if not diagnosed and managed expeditiously may have dire consequences for both the patient and physician. We present a case of an elderly patient with a life-threatening unusual cause of acute shortness of breath, a diaphragmatic hernia with sepsis.
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PMID:An unusual cause of dyspnea. 1679 52

Sudden onset of shortness of breath and chest pain as well as a decreased oxygen level in the blood can be signs that a patient is experiencing a pulmonary embolic episode; however, a great many other conditions also can cause these signs and symptoms. If left undiagnosed and untreated, pulmonary embolism can be potentially fatal. This article describes types of medical imaging used to evaluate possible pulmonary embolism, including conventional chest radiographs, spiral computed tomography, magnetic resonance imaging and nuclear medicine lung ventilation and perfusion imaging.
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PMID:Pulmonary embolism imaging. 1686 26

Pulmonary involvement may sometimes be the initial presentation of Takayasu's arteritis (TA). Since the signs and symptoms of pulmonary TA may be subtle and may not be easily distinguishable from other pulmonary diseases, one has to maintain a high index of suspicion. Cases of pulmonary TA mimicking chronic thromboembolism have been reported. We describe a patient with TA whose initial presentation mimicked acute pulmonary embolism. The patient presented with a 3-day history of cough and shortness of breath and had multiple bilateral perfusion defects on ventilation-perfusion scan, typical of acute pulmonary embolism. However, the constellation of clinical features, elevated erythrocyte sedimentation rate and the angiographic appearance helped us establish the correct diagnosis of pulmonary Takayasu's arteritis. At a 6-year follow-up, the patient had no worsening of pulmonary symptoms but presented with postural dizziness with angiographic evidence of carotid and innominate artery stenosis; she underwent arterial bypass grafting. In young women presenting with a clinical picture of acute pulmonary embolism without the previous history (or risk factors) of thromboembolism, pulmonary TA must be considered in the differential diagnosis.
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PMID:Pulmonary Takayasu's arteritis masquerading as acute pulmonary embolism. 1703 81

A 58-year-old patient with recently diagnosed non-small cell bronchial carcinoma was referred to us with increasing shortness of breath and orthopnea by her family practitioner. To exclude the possibility of a pulmonary embolism, contrast medium-enhanced angio-CT of the thorax was performed. This showed a large mediastinal tumor, which, on the one hand, infiltrated and occluded the left upper lobe bronchus and, on the other, constricted the left pulmonary artery over a considerable part of its length. In view of the palliative situation and massively increasing dyspnea, balloon dilatation of the obstructed left pulmonary artery followed by stent placement was performed. This resulted in an immediate improvement of the symptoms. The originally strongly oxygen-dependent and heavily dyspneic patient could be relieved of the external supply of oxygen and was able to sleep normally without additional medication within 24 h. The patient was able ambulate freely within 2 days, with a markedly improved quality of life.
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PMID:Stent implantation for malignant pulmonary artery stenosis in a metastasizing non-small cell bronchial carcinoma. 1765 22

This study deals with clinical features, course and results of an eleven year follow-up of 22 patients with myxoma of the heart, 16 females and 6 males, mean age 48 years. Left atrial myxoma was found in 18 patients (82%) and right atrial myxoma in 4. The most frequent clinical features were fatigue in 64%, shortness of breath in 82%, systemic pulmonary embolism in 50% and prolonged fever in 27% of patients. On auscultation of the heart diastolic murmur was found in the mitral area in 36% and in tricuspid area in 14% of patients. The most helpful diagnostic noninvasive procedure was echocardiography which showed myxoma of the heart in all 22 patients. Left and right heart catheterisation studies were performed in 11 patients; in all patients with left atrial myxoma various degrees of pulmonary hypertension were found. Twenty one patients underwent open heart surgery; in twenty removal of myxoma was performed and in one concomitant mitral valve replacement was done. The mean follow-up of this group of patients was 6.2 years. All patients were asymptomatic and without clinical or echocardiographic signs of reccurrence.
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PMID:[Myxoma of the heart--clinical features, course and long term follow-up]. 1797 99

Atrial fibrillation is a rare diagnosis in children and adolescents. We report a case of a 17-year-old previously healthy boy who presented to the emergency department with a 3-week history of shortness of breath, chest pain, and 1 episode of hemoptysis. Symptoms persisted despite a course of antibiotics and anti-inflammatory agents. The patient developed palpitations and was found to be in atrial fibrillation at the time of hospitalization. An extensive workup led to the diagnosis of pulmonary embolism. This case highlights the importance of evaluating for thromboembolic events in pediatric patients presenting with new-onset atrial fibrillation and typical electrocardiogram pattern of cor pulmonale with or without respiratory symptoms.
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PMID:Atrial fibrillation and pulmonary embolism. 1800 16

Thirty two year old Caucasian female presented 2 months post partum with fevers, cough and shortness of breath. CT scan of the chest to rule out pulmonary embolism revealed mediastinal lymphadenopathy. Biopsy of the nodes revealed classic Hodgkin's lymphoma and she received ABVD chemotherapy. She was in remission as confirmed by a PET/CT scan. Five months later she had another PET/CT scan which showed areas of hypermetabolism indicating a possible relapse. Biopsy revealed sarcoidosis. She received steroids and 18 months later remained in clinical remission. This rare case of sarcoid following classic Hodgkin's lymphoma illustrates that clinical presentation, physical exam, lab investigations and even PET/CT scans may not be able to discriminate between Hodgkin's lymphoma and sarcoidosis. Tissue biopsy and pathological diagnosis remain the gold standard.
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PMID:Tissue is the issue-sarcoidosis following ABVD chemotherapy for Hodgkin's lymphoma: a case report. 1803 49

Primary pulmonary artery sarcoma is an uncommon tumor. We report a case of a 73-year-old male patient with a two-week history of palpitations and shortness of breath, aggravated for two days and was believed to be pulmonary hypertension. Emergency heart ultrasound after admission presented a massive pulmonary embolism in the pulmonary artery. The patient's condition was successfully managed with urgent pulmonary artery embolectomy. The patient demonstrated improvement in hemodynamics after the operation. Histologic and immunohistochemical assays were performed and a diagnosis was made as primary pulmonary artery sarcoma arising from the left pulmonary artery. Resection of the tumor is recommended for the treatment of this rare malignant tumor. The corresponding chemotherapy, follow-up and prognosis are described as well in this case report.
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PMID:Primary pulmonary artery sarcoma. 1846 25


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