Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0034065 (pulmonary embolism)
 14,979 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Abstract A 57-year-old woman with RA of 10 years' duration presented with a history of right coxalgia. Three weeks after total hip arthroplasty, the patient developed an acute pulmonary embolism. The results of screening for hypercoagulable states revealed a protein S (PS) deficiency, and all PS values, i.e., total PS antigen, free PS antigen, and PS cofactor, were lower than the normal ranges, showing that the patient had type I PS deficiency. She had no past history of embolism or deep venous thrombosis. The values of three PS-related parameters were also lower than normal in her daughter. The responsible mutation may be located on exon 15 of genomic PS DNA, as indicated by polymerase chain reaction. We therefore diagnosed hereditary PS deficiency.
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PMID:Hereditary protein S deficiency associated with rheumatoid arthritis: a case report of pulmonary embolism after total hip arthroplasty. 2438 78

Deep venous thrombosis (DVT) is a disease presenting with thrombosis and obstruction of its branches and interruption of blood flow of lower extremities. Pain, severe discomfort and swelling are the most frequent symptoms of DVT and the most life-threatening manifestation is pulmonary embolism. Herein an otherwise healthy, 27-year-old male patient presented with severe left inguinal and hip pain due to the DVT of proximal left lower extremity is presented. We assume that DVT should be kept in mind in patients presenting with musculoskeletal system pain, as it may cause life-threatening complications such as pulmonary thromboembolism.
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PMID:Deep venous thrombosis in a patient presenting with severe left inguinal and hip pain: a case report. 2569 22