Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034065 (pulmonary embolism)
 14,979 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Between october, 1982 and december, 1986, 17 patients were implanted with an automatic defibrillator. The thoracic route was used in 6 patients with installation of an epicardial patch and an endocavitary electrode. The subcostal route was used in the remaining 11 patients, with 2 epicardial patches. The device, badly tolerated by 2 of the first 6 patients, created no problem in the 11 patients of the second group. One patient died of pulmonary embolism on the 6th post-operative day. At follow-up, there was no inappropriate triggering of the AID-B: 8 patients had neither arrhythmia nor shock, and 8 received from 2 to 55 shocks with documented arrhythmia. Two patients died suddenly: one after end of life of the device, the other after 3 years, while the device was still working. The implantable defibrillator technique has improved and local complications are now seldom observed. The device is reliable and constitutes an effective weapon against sudden death caused by ventricular arrhythmia.
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PMID:[The implantable defibrillator. Long-term clinical results]. 296 69

Between October 1982 and May 1986, 12 patients were implanted with an automatic defibrillator AID-B; 7 had coronary artery disease, 2 had dilated cardiomyopathies and 3 had torsades de pointe with or without long QT intervals. Five patients had a thoracic approach with a left ventricular patch and implantation of a right atrial endocavitary electrode. Thereafter a subcostal approach was used with 2 patch electrodes. Two of the first 5 patients rejected the device, but this complication was not observed in the remaining 7 cases. The threshold of defibrillation was greater than 25 joules in 1 case out of 5 with a patch and endocavitary electrode. This threshold was less than 25 joules in all patients with 2 patch electrodes. The AID-B was triggered in less than 20 seconds. One patient died of pulmonary embolism 8 days after implantation; 2 others had a temporary aggravation of their arrhythmias. There were no cases of inappropriate activation of the AID-B device during follow up: 5 patients had no arrhythmia or defibrillation. The 6 others had 2 to 35 defibrillations with documented arrhythmias before or after defibrillation. One patient suffered a sudden death after exhaustion of the device which had functioned on two occasions but had not been replaced for economic reasons. The technique of implantation has been simplified, so limiting local complications. This device is reliable and represents an effective palliative treatment of sudden death due to ventricular arrhythmias.
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PMID:[Long-term clinical results of the implantable automatic defibrillator]. 310 88

We implanted the automatic implantable defibrillator model B (AID-B) in 11 patients (pts). Seven pts had coronary disease with sustained VT, and/or VF. Two had syncopal VT due to primary cardiomyopathy, and two pts had syncopal torsades de pointes (Tdp) without cardiac disease (1 long QT syndrome). These arrhythmias occurred despite antiarrhythmic drugs or beta blockers. Four pts had implanted: an epicardial patch by thoracotomy, an intra-atrial string electrode by the jugular vein, then AID-B by abdominal route. In 7 pts, subcostal approach was used, for implanting simultaneously 2 epicardial patches and the AID-B itself. During the operation, VT, Tdp and/or VF were induced in all pts by 50 Hz alternating current. The defibrillation threshold (DT) between atrial catheter and epicardial patch was less than 15 J in 4 pts, and greater than 25 J in two, requiring a larger patch in 1, and replacement of atrial electrode by another patch in the 2nd pt to obtain a DT less than 20 J. In the 6 pts implanted with 2 patches, DT was always less than 25 J. In 3 pts, DT was markedly higher for VF (25 J) than for VT (less than 15 J). One pt died from pulmonary embolism, another died after 3 years, before replacement of a failing battery, and a third died from progressive congestive heart failure, 6 months later. Eight pts are alive with a follow-up greater than 6 months. Local aseptic reactions obliged a removal of the implant in 2 pts operated by bifocal approach, and none when the subcostal route was used.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Clinical use of automatic implantable defibrillators. 367 54