Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034065 (pulmonary embolism)
 14,979 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Platelet plays an important role in thromboembolic diseases. It is demonstrated that recurrent pulmonary embolism may cause pulmonary hypertention. In recent years, P-selectin (granule membrane protein, GMP140) was found to be a surface marker for platelet activation. In order to investigate the role of platelet in chronic cor pulmonale, the changes of P-selectin on platelet membrane and its effect on platelet adhesiveness (PAdT) and platelet aggregation (PAgT) were studied. The results showed that the changes of P-selectin PAdT and PAgT in chronic cor pulmonale were significant than those in chronic pulmonary diseases and controls (P < 0.01). There was positive correlation between P-selectin and PAdT (r = 0.6831, P < 0.01) as well as PAgT (r = 0.7142, P < 0.01). The levels of von Willebrand factor (vWF) and fibrinogen (Fg) were markedly increased in chronic cor pulmonale as compared with chronic pulmonary disease and control group (P < 0.01). There was also positive correlation between vWF and PAgT (r = 0.4143, P < 0.05) as well as between Fg and PAgT (r = 0.4392, P < 0.05). It is concluded that platelet plays an important role in the pathogenesis of chronic cor pulmonale.
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PMID:[The relationship between P-selectin on platelet membrane and platelet function in chronic cor pulmonale]. 754 26