Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034065 (pulmonary embolism)
 14,979 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Intravenous dobutamine was used in ten patients requiring aggressive therapy for massive pulmonary embolism with circulatory failure. Except in one patient who rapidly died, a 30-min dobutamine infusion (8.3 +/- 2.7 micrograms/kg . min) increased both cardiac index (from 1.7 +/- 0.4 to 2.3 +/- 0.6 L/min . m2, p less than .001) and stroke index (from 16.6 +/- 6.7 to 21 +/- 5 ml/m2, p less than .01), and also reduced pulmonary vascular resistance. Additional hemodynamic improvement was observed until weaning from dobutamine, which was successfully completed 3.3 +/- 0.9 days after the start of infusion.
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PMID:Dobutamine: a hemodynamic evaluation in pulmonary embolism shock. 406 10

The scientific basis for the statement that cigarette smoking increases the risk of serious cardiovascular side effects from oral contraceptive (OC) use is reviewed. The published literature and the new statistical analyses of the data are examined. Attention is directed to 3 broad categories of relevant vascular disease--deep vein thrombosis and pulmonary embolism, stroke--both occlusive and hemorrhagic, and ischemic heart disease. Within each category, the epidemiologic relationship of cigarette smoking alone, of OC use, and of a combination of the 2 is addressed. This review of smoking and OC use as risk factors for major classes of cardiovascular disease reveals little convincing evidence for an interaction of the smoking and OC use. Essentially all of the data have been interpreted to indicate that OC use is a risk factor for cardiovascular disorders derive from retrospective case-control studies, which continue to be a subject of controversy. The role of smoking as a risk factor appears to be little questioned in the case of myocardial infarction, and the evidence suggests that it may also be a factor in hemorrhagic stroke. There is little evidence to implicate smoking in the pathogenesis of thrombotic stroke in young women, and several publications suggest that it has a protective effect for deep vein thrombosis. In sum, evidence for an interaction of smoking and OC use has been reported but is deemed to be weak. A major existing difficulty is the methodological problems that are inherent in epidemiologic investigations, both retrospective and prospective. While conservatism could thus withhold needed and effective contraception, the recommendation is for the OC user to forego smoking.
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PMID:Smoking, oral contraceptives, and thromboembolic disease. 612 53

Over the January 1, 1979 to March 31, 1980 period sterilization-attributable deaths were identified in Dacca and Rajshahi Divisions, Bangladesh. These deaths were identified primarily through government records of compensation to families of deceased sterilization patients. This list was augmented by deaths reported from clinics of the Bangladesh Association for Voluntary Sterilization, detected through a prospective study of sterilization in Bangladesh, and identified by interviews with government family planning officials. A sterilization-associated death was defined as the death of a patient from any cause occurring within 42 days of tubal ligation or vasectomy. Death-to-case rates for vasectomy and tubal ligation were calculated for each month with 95% confidence intervals based on the Poisson distribution. 31 sterilization-associated deaths were identified over the study period. 28 of these were sterilization attributable and 3 were not. The mean age of the 21 women was 30.6 years, and their mean parity was 4.8. The mean age of the 7 vasectomy patients was 37.0 years. Abdominal Pomeroy method of tubal ligation was the only female sterilization technique used. 2 temporal clusters of sterilization attributable deaths occurred during the study. The 1st was a cluster of 5 deaths from tubal ligation performed in June 1979. 3 of these operations took place on June 5, 1979 but in different facilities. 1 factor common to each of these operations was the unseasonably hot weather. The 2nd temporal cluster consisted of 3 deaths after vasectomy in July 1979. 2 men from the same village died from scrotal infections after vasectomy on July 19, 1979 by the same surgeon at a single clinic. A similar death occurred earlier the same month. Another patient of the same surgeon and clinic associated with the deaths after operation on July 19 died from scrotal infection in January 1980. 3 vasectomy deaths related to 1 surgeon in a single remote facility suggests a breach of sterile technique. This could not be confirmed as this clinic physician could not be interviewed. The death-to-case rate for all procedures combined was 21.3 deaths/100,000 procedures, with the rate for vasectomy 1.6 times higher than that for tubal ligation. Anesthesia overdosage was the leading cause of death attributed to tubal ligation with tetanus (24%), intraperitoneal hemorrhage (14%), and infection other than tetanus (5%) as other leading causes. 2 patients (10%) died from pulmonary embolism after tubal ligation; 1 (5%) died from each of the following: anaphylaxis from anti-tetanus serum, heat stroke, small bowel obstruction, and aspiration of vomitus. All 7 men died from scrotal infections after vasectomy. Improvement in anesthesia management and sterile technique can lower the death-to-case rate for contraceptive sterilization in 2 Divisions of Bangladesh.
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PMID:Sterilization-attributable deaths in bangladesh. 612 37

Acute right ventricular failure is commonly observed during respiratory intensive care, particularly in patients suffering from massive pulmonary embolism, chronic obstructive pulmonary disease or adult respiratory distress syndrome. The haemodynamic effects of a continuous dobutamine infusion at the rate of 9.4 +/- 3.7 micrograms/kg/min were assessed in a group of 15 patients with acute and isolated right ventricular failure, as evidenced by haemodynamic and two dimensional echocardiographic measurements. This inotropic agent induced at 37% increase in mean cardiac index and a 25% increase in mean stroke index, with only a 10% increase in mean heart rate. Moreover, measurement of the right ventricular ejection fraction by a thermal dilution technique performed in 10 patients demonstrated that dobutamine consistently and significantly increased right ventricular systolic function and also significantly reduced right ventricular end-diastolic tension. In conclusion, it appeared that dobutamine was able to improve circulatory status in patients with acute right heart failure or various origins.
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PMID:[Acute right ventricular failure. Treatment with dobutamine]. 623 54

Coronary artery disease and the ability of noninvasive exercise perfusion imaging with thallium-201 to predict future coronary and cardiovascular events was prospectively evaluated in a group of 85 insulin-dependent diabetic renal transplantation candidates. Sixty patients received renal allografts (36 living related donors, 24 cadaver donors) after a thallium stress test; the actuarial 2 year patient survival rate after transplantation was 84 percent. Twenty-five patients remained on dialysis, and the 2 year actuarial survival rate from onset of dialysis was 41 percent, significantly lower than the actuarial survival rate of transplanted patients (p less than 0.01). Thirteen transplanted patients had positive thallium stress test results, and 6 (46 percent) had cardiovascular events (two fatal). In contrast, of 47 transplant patients with negative thallium stress test results, only 13 (28 percent) had cardiovascular events (four fatal). Five patients treated by hemodialysis only had positive test results and three (60 percent) had cardiovascular events (two fatal), whereas of 20 hemodialysis patients with negative test results, 9 (45 percent) suffered cardiovascular events (four fatal). In this study, cardiovascular events included arrhythmia, stroke, and pulmonary embolism. Within the total group, 4 of 18 patients (22 percent) with a positive test result (22 percent) had a fatal myocardial infarction, whereas only 3 of 67 patients (4 percent) with a negative result had a fatal myocardial infarction (p less than 0.05). In comparison, 24 of 85 patients had a history or electrocardiographic evidence of preexisting cardiovascular disease, and 13 (54 percent) had subsequent cardiovascular events (5 of 11 patients with positive test results and 8 of 13 patients with negative results). In summary, renal transplant candidates with positive thallium stress test results appear to be at increased risk compared with those with negative results for the development of fatal myocardial infarction, but thallium stress testing is no more predictive for future coronary and cardiovascular events than is a history or an abnormal electrocardiogram.
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PMID:Predictive value of thallium stress testing for coronary and cardiovascular events in uremic diabetic patients before renal transplantation. 635 48

Pulmonary emboli may impair myocardial performance, causing declines in cardiac index (CI) and right and left ventricular stroke work (LVSW) because of mechanical events. We postulate that embolism also leads to the generation of a humoral factor(s) that may reduce cardiac contractility. Eleven mongrel dogs were infused with 0.5 gm/kg clot. Decreases in CI and LVSW were observed 1 hour after embolization. The stable metabolites of prostacyclin and thromboxane (Tx) A2--6-keto-PGF1 alpha and TxB2, respectively--increased within 30 minutes (P less than 0.005, P les than 0.001) and then decreased. These changes did not correlate with the declines in CI or LVSW. Plasma from embolized animals used to bathe an isolated rat papillary muscle reduced developed tension (Tpd) (P less than 0.001) and decreased calcium ATPase (Ca++-ATPase) activity of a myofibril preparation (P less than 0.001) obtained from rat cardiac muscle. The correlation between the reduction of TPd and myofibril Ca++-ATPase activity was 0.72 (P less than 0.001). The decline in Ca++-ATPase was also related to the decreases in CI (r = 0.59, P less than 0.001) and LVSW (r = 0.57, P less than 0.001). Five animals pretreated with indomethacin prior to embolization had no decrease in LVSW as compared with controls (P less than 0.001). Postembolism plasma did not depress papillary muscle Tpd and did not lower Ca++-ATPase activity of myofibrils. Anesthesia itself did not alter cardiopulmonary function. These results suggest that pulmonary emboli cause the release of a negative inotropic agent(s) into plasma that affects energy availability in the heart and reduces contractility. The production of this agent(s) is inhibited by indomethacin pretreatment.
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PMID:Circulating negative inotropic agent(s) following pulmonary embolism. 646 Oct 81

The frequency of venous disease probably surpasses that of heart disease and stroke. The fallibility of the clinical diagnosis of pulmonary embolism and deep vein thrombosis (DVT) approaches 50% error in both conditions. Because of the serious errors in omission and commission of the clinical diagnosis of venous thrombosis, a variety of noninvasive diagnostic techniques have been developed within the past decade. The purpose of this paper is to analyze these noninvasive venous modalities with more emphasis on what is available in our vascular lab at Charleston Area Medical Center-Charleston Division, West Virginia University Medical Center.
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PMID:Current status of the vascular laboratory in the diagnosis of deep vein thrombosis. 649 49

The risk of thromboembolism in oral contraceptive (OC) users is evaluated based on findings of major cohort studies conducted in England, the US, and Denmark. Since approximately 25% of Danish Women aged 15-45 use OCs, such an assessment is timely and critical. A study by the Royal College of General Practitioners (RCGP) found a slightly higher risk of venous thrombosis and pulmonary embolism, especially postoperatively (deep venous thrombosis). Major risk was found only with the use of high estrogen-content pills. No connection between OC use and subarachnoidal bleeding could be established according to the latest studies. In a US study examining 182 cases of apoplexy cerebri of thrombotic origin in comparison with 98 controls, the risk was 9.5 times higher on OC users. However, 74% of the patients with cerebral thrombosis were smokers vs. 43% of controls. The high gestagen component of pills was implicated in the increased risk. In a case control study, the risk of myocardial infarct was found 4 times higher in OC users and 20 times higher in smokers who used OCs. Another study of the RCGP supported these findings: myocardial infarct was .3/1000 women per year in pill users vs. .15 in nonusers, and the risk of death from ischemic heart disease was 6.4 times higher among users. These risk factors were also borne out by Danish data: the number of women aged 35-39 and 40-45 dying of ischemic heart disease between 1951-1981 rose slightly, but there was no significant increase after 1967, when low-dose OCs were introduced; in recent years there has been a decline. To establish a firm link between the use of the estrogen and gestagen components of OCs and thromboembolic disease, further investigations must be conducted in view of recently introduced low-dose pills.
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PMID:[The pill and thrombosis]. 651 90

This paper describes a consecutive series of 215 carotid bifurcation endarterectomies performed by one surgeon for transient ischaemic attacks. One patient died from a pulmonary embolism (0.47 per cent). One patient developed a permanent stroke related to the contralateral hemisphere 3 days after operation (0.47 per cent). Five patients developed a weakness of one arm or hand which had clinically recovered 2 months after operation (2.35 per cent); four patients had a transient weakness of one arm or hand which had recovered in less than 24 h of the operation. There were no serious ocular complications. The incidence of serious permanent complications was therefore 0.94 per cent. The Javid shunt could not be used in only 4 of the 193 operations in which its insertion was attempted. It caused arterial damage in only one patient. The results suggest that the routine use of the shunt was of value and that carotid endarterectomy can be a safe, relatively complication-free, procedure.
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PMID:Carotid endarterectomy and the Javid shunt: the early results of 215 consecutive operations for transient ischaemic attacks. 668 72

Analysis of early deaths after stroke is important, since some deaths may be preventable. Previous studies have relied on retrospective and often incomplete clinical data, for comparison with pathological findings. The present study is based on 1073 consecutive stroke patients admitted to an intensive care stroke unit from a well-defined population. There were 212 deaths within the first 30 days, yielding a mortality rate of 20%. Clinical, radiological, and laboratory data were collected prospectively according to a standardized protocol. Autopsies were performed on 90 of the 212 patients, and CT scanning on a further 27. Early mortality after stroke exhibits a bimodal distribution. One peak occurs during the first week, and a second during the second and third weeks. The majority of deaths in the first week are due to transtentorial herniation. Of these, deaths due to hemorrhage usually occur within the first three days, whilst deaths due to infarction peak between the third and sixth day post ictus. After the first week, deaths due to relative immobility (pneumonia, pulmonary embolism and sepsis) predominate, peaking towards the end of the second week. Cardiac deaths occur throughout the first month, and unfortunately account for many deaths in patients with small functional deficits.
Stroke
PMID:Early mortality following stroke: a prospective review. 672 78


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