Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0034065 (pulmonary embolism)
 14,979 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A prospective randomized controlled study has been undertaken to evaluate two different prophylactic treatments against postoperative thromboembolic complications after hip surgery. Patients with hip fracture (77) and patients undergoing elective hip arthroplasty (213) were separately randomized into one of three groups: control, dextran 70, or low-dose heparin. Deep vein thrombosis was diagnosed in both groups with the 125I-fibrinogen test and pulmonary perfusion defects in the arthroplasty group with a combination of pulmonary X-ray and perfusion scintigraphy. The frequency of thrombosis was significantly higher in untreated hip fracture patients than in untreated arthroplasty patients. In hip fracture patients both treatments significantly reduced the frequency of thrombosis. Only dextran reduced the frequency of major thrombosis and in the heparin group one fatal pulmonary embolism occurred. After elective hip surgery the overall frequency of thrombosis was not influenced by the two treatments, but with dextran 70 thigh thrombi were reduced and with low-dose heparin the frequency of bilateral thrombosis was reduced. Two patients in the control group died of pulmonary embolism, but the frequency of pulmonary perfusion defects was not influenced by the treatment. Bleeding and transfusions were the same in the three groups.
 ...
PMID:Thromboembolism after elective and post-traumatic hip surgery--a controlled prophylactic trial with dextran 70 and low-dose heparin. 38 76

The efficacy of a six-month course of low-dose heparin therapy was compared to a conventional warfarin regimen by a prospective, controlled trial in 48 patients with pulmonary embolism or deep venous thrombosis of the legs. All subjects had complicated medical illnesses and a high risk of recurrent thromboembolism. Bleeding complications were virtually negligible during heparin therapy and occurred significantly more frequently in patients receiving warfarin. Heparin was as effective as warfarin in the prevention of recurrent thromboembolism. Patient compliance with the two treatment regimens was comparable. Self-administered, low-dose heparin therapy is a useful alternative to warfarin in the long-term management of complicated thromboembolic disorders.
 ...
PMID:Low-dose heparin therapy in the long-term management of venous thromboembolism. 38 91

This paper is based upon a study of all available records of patients certified as having died in hospital from pemphigus and pemphigoid in England and Wales from 1962 to 1969. The results differ from most published series in that many of the 210 patients died still with extensive skin lesions and with biochemical abnormalities, such as low serum albumin, sodium and chloride, which were secondary to this. Side-effects of treatment, such as diabetes, peptic ulceration, and infections, were also important but the commonest immediate causes of death were respiratory tract infections and pulmonary embolism.
 ...
PMID:The events leading to the death of patients with pemphigus and pemphigoid. 39 Dec 61

The authors report their experience with graded-pressure elastic hose (TED Stockings) for the prevention of deep venous thrombosis of the lower limbs and pulmonary embolism in high-risk, bedridden postoperative patients. The trial was designed according to a closed sequential program and gave positive, statistically significant results in terms of preventing pathology with this type of hose.
 ...
PMID:[Graduated and constant compression of the lower extremities in the prevention of postoperative deep venous thrombosis and of pulmonary thromboembolism. Clinical trial]. 39 49

The spectrum of pulmonary complications in 28 of 66 burn victims is analyzed according to time of onset and resultant radiographic features. Immediately recognizable pulmonary abnormalities are usually due to chemical pulmonary edema and inhalation pneumonitis. Complications manifested 2-5 days after injury include pulmonary microembolism, adult respiratory distress syndrome, and atelectasis. Delayed complications are major pulmonary embolism, pneumonia, and adult respiratory distress syndrome. In this series, 25 patients (89%) developing pulmonary complications died. The critical role of serial chest radiographs in the evaluation and management of burn victims is emphasized.
 ...
PMID:The radiographic spectrum of pulmonary complications in burn victims. 40 38

The nature and mechanisms of pulmonary vascular responses which follow miliary pulmonary embolism were examined in intact dogs in which the isolated left lower lobe was perfused at constant blood flow. Embolization of the lung with plastic microspheres increased total pulmonary vascular resistance, whereas, in contrast, vascular resistance of the isolated perfused left lower lobe which was protected from embolization was decreased. This vasodilation was prevented by chronic denervation of the lobe and by ganglionic blockade. Cervical vagotomy also blocked the response but atropine failed to alter the vasodilation. The response, which appeared to be reflex in origin and involve efferent sympathetic pathways, was prevented by beta-adrenergic receptor blockade produced by propranolol. Since the lobar vascular response to norepinephrine was significantly enhanced by propranolol, it was concluded that embolization of the lung evokes pulmonary vascular reflex vasodilation which is mediated over the sympathetic nervous system via a beta-adrenergic receptor mechanism.
 ...
PMID:Studies on the mechanism of pulmonary vascular responses to miliary pulmonary embolism. 41 6

Four months before her death of right heart failure, a 38-year-old woman with a known inoperable echinococcosis of the liver developed fever, increasing eosinophilia and pleuropneumonia. After improvement of the clinical, radiological and laboratory parameters under steroid medication, two months before her death hemoptysis and multifocal perfusion defects in the lung scintigram as a sign of pulmonary embolism occurred, for which heparin therapy was introduced. At autopsy a recurrent embolization due to echinococcus cysts with extensive displacement of the arterial pulmonary blood circulation were found.
 ...
PMID:[Embolization of the lung in echinococcosis (author's transl)]. 41 81

In the performance of pulmonary arteriography, the anteroposterior projection may be insufficient for the diagnosis of pulmonary embolism, and additional views, usually oblique, are required. Of 57 positive pulmonary arteriograms which were reviewed, additional views were necessary in 26 cases. The efficacy of the additional views in each case was assessed with regard to the demonstration of the segmental arteries of the various lobes of the lung. Following an inconclusive anteroposterior injection, the best visualization of the arteries of the right lung can generally be obtained with an injection made in the right posterior oblique projection. Similarly, following an inconclusive anteroposterior injection, the left posterior oblique or lateral view is recommended for optimal visualization of the pulmonary vasculature of the left lung.
 ...
PMID:Pulmonary angiography for pulmonary emboli: rational selection of oblique views. 41 52

Independent, random, and multiple evaluations by three observers of pulmonary perfusion scintiscans with and without ventilation scans demonstrated a 39% reduction in diagnosis of pulmonary embolism when ventilation scans were included. These findings suggest that four of 10 cases diagnosed as having pulmonary emboli on the basis of perfusion imaging procedures alone would have the diagnosis changed.
 ...
PMID:Effect of ventilation images on observer interpretation of lung perfusion examinations. 41 36

In 75 patients with various pulmonary disorders, ventilation and perfusion scans were obtained in multiple views with the 81mKr/99mTc technique and compared with an evaluation of regional ventilation and perfusion derived from the standard chest radiograph. In emphysema, the chest film correlated poorly with ventilation-perfusion scans, showing a trend to underestimate the functional impairment. In chronic bronchitis and asthma, large segmental defects observed on both ventilation and perfusion scans were associated with a normal chest radiograph. Typical findings in pulmonary embolism were segmental defects on perfusion scan with normal ventilation scan and clear lung fields on the chest film. In chronic left heart disease, plain films were inaccurate in predicting alteration of the base-to-apex perfusion gradient observed on the scan.
 ...
PMID:81mKr ventilation and 99mTc perfusion scans in chest disease: comparison with standard radiographs. 41 42


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>