Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034065 (pulmonary embolism)
 14,979 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An 18 year old woman was hospitalized because of a vena cava inferior thrombosis, renal vein thrombosis, and pulmonary embolism due to an inherited protein C deficiency. She received 3 months of contraceptive treatment with estrogens. Protein deficiency was detected in 12 other members of her family; her father had a pulmonary embolism 12 years earlier and 2 other members of the family may have died of thromboembolism. (author's modified)
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PMID:[Protein C deficiency and the P pill]. 204 36

Constitutional deficiency in C-protein appears to be a very often underestimated or unrecognized cause of thromboembolic disease. C-protein deficiency in a family (father, son and daughter) was associated with clinical manifestations of thrombosis (post-embolic cor pulmonale, fatal pulmonary embolism, post-partum phlebitis), all appearing before 35 years of age. These three cases confirm the absolute need for routine exploration of physiologic inhibitors of coagulation in all young patients with venous thrombosis.
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PMID:[Familial protein C deficiency and venous thrombosis]. 362 46

A case of a 44-year-old-man with chronic thromboembolic pulmonary hypertension (PH) and C-protein deficiency, with a history of previous acute pulmonary embolism is presented. The ECG showed negative T waves in leads: II, III, aVF and V(1)-V(6). The follow-up echocardiography revealed severe PH with the right ventricular systolic pressure (RVSP) - 95-100 mm Hg, markedly enlarged right ventricular end-diastolic diameter (RVEDD), and decreased left ventricular end-diastolic diameter (LVEDD). The patient was in NYHA III/IV class. He was referred for pulmonary thromboendarterectomy. Three months after thromboendarterectomy echocardiography showed marked reduction of RVEDD, increased LVEDD, RVSP - 50-55 mm Hg. The 3 months follow-up ECG showed normalisation to positive T waves. The patient was in NYHA class I and he stayed on the anticoagulation therapy.
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PMID:[Dynamic ECG changes after thromboendarterectomy in a patient with chronic thromboembolic pulmonary hypertension and C protein deficiency]. 2282 55