Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034063 (pulmonary edema)
 10,665 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pulmonary tissue volume (Vt) and pulmonary capillary blood flow (Qc) were measured in anesthetized dogs by analyzing end-expiratory concentrations of dimethyl ether (DME), acetylene (C2H2), and sulfur hexafluoride during a 30-s rebreathing maneuver. Vt was compared to the postmortem lung weight of control dogs and dogs with hemodynamic and nonhemodynamic (alloxan) pulmonary edema. Qc was compared to the cardiac output measured by dye dilution. A 100-ml increase in alveolar volume (VA) in the range of 1-2 liters resulted in a 9 +/- 3 ml increase in Vt. Vt measured at a VA of 1.9 liters measures 114 +/- 18% of the postmortem lung weight in 20 control dogs and in 6 dogs with moderate edema (lung weight < 250% of predicted). Vt measured only 53 +/- 14% of the lung weight in 11 dogs with more severe edema. DME and C2H2 gave the smae mean values of Vt, but the reproducibility of a series of 3-7 measurements was greater with DME (coefficient of variation was 5% with DME and 8% C2H2). Qc measured 96 +/ 15% of the cardiac output during the rebreathing maneuver, but the maneuver caused a 4-40% fall in the cardiac output. These data show that Vt determined by rebreathing DME is between 86% and 135% of the lung weight in dogs with pulmonary edema until the lung weight is greater than 250% of the predicted value.
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PMID:Pulmonary tissue volume in dogs during pulmonary edema. 64 78

We measured pulmonary tissue volume (Vt) and pulmonary capillary blood flow (Qc) by a rebreathing method using two soluble gases, acetylene (C2H2) and dimethyl ether (DME), in 32 normal subjects and 14 patients who had had pulmonary edema. In 18 of the normal subjects, studies were performed at three or more different rebreathing volumes (VA). To normalize for differences in body size, results were expressed as the ratio of Vt or VA to predicted total lung capacity (TLC). We found that 1) changes in VA/TLC had a significant effect on Vt/TLC and Qc measured with both gases, 2) the range of normal values for Vt was best defined by expressing the relationship between Vt/TLC and VA/TLC, 3) using this approach, many patients with clinically mild or inapparent pulmonary edema had abnormal values of Vt, and 4) when comparing mean values of C2H2 and DME in 82 simultaneous measurements at constant VA/TLC, Vt was significantly higher in 87% (71/82) and Qc in 63% (52/82) of the paired tests.
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PMID:Measurement of pulmonary tissue volume and blood flow in persons with normal and edematous lungs. 731 70