Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034063 (pulmonary edema)
 10,665 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The pulmonary edema (PE) induced by adrenaline (AD) is similar to neurogenic pulmonary edema. Anisodamine (654-2) showed an apparent therapeutic effect on it. The pulmonary wedge arterial pressure (PAWP), carotid arterial pressure (CAP) and blood gases were measured. It was found that in PE group, PAWP was increased to four-fold compared with those from before AD administration (from 0.98 +/- 0.24 to 4.04 +/- 0.53 kPa, mean +/- SD) rapidly. CAP was increased to one fold. The changes of PaO2,O2Sat and PaCO2 showed progressive hypoxia. The PaO2(kPa) was 11.0 +/- 1.3, 6.1 +/- 1.7, 4.4 +/- 1.9 and 3.8 +/- 1.9, PaCO2(kPa) was 4.1 +/- 2.1, 5.4 +/- 0.8, 9.7 +/- 2.9 and 10.3 +/- 3.4, O2 Sat(%) was 95.6 +/- 16.0, 69.2 +/- 15.1, 48.9 +/- 22.0, and 33.7 +/- 25.9 in order before AD injection, 1, 5 min after AD injection and before death respectively. Blood pH value also decreased in apparent way. All of animal died within 15 min. While in 654-2 therapeutic group, the significant increased PAWP and CAP were decreased gradually to normal within 30 min. The abnormal blood gases and pH were approached to repair within 20 min. All of animals survived.
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PMID:[Experimental study of anisodamine on therapeutic effect of pulmonary edema in rats]. 142 80

The pulmonary edema (PE) induced by adrenaline (AD) administration is similar to neurogenic PE. Anisodamine (ADM, 654-2, 30 mg/kg) and tetramethylpyrazine (TMP, 120 mg/kg) have shown significant preventive effects. Electron microscopic observation was carried out to study the changes of microvascular permeability, and the dynamic change of mean pulmonary arterial pressure (PAP, 40 rats), mean pulmonary arterial wedge pressure (PAWP, 20 rats) and mean carotid arterial pressure (CAP) were also measured. The results suggested that both ADM and TMP have significant inhibitory effects on PAWP and CAP increase, as well as on the damage responsible for the increase of microvascular and alveolar permeability.
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PMID:Hemodynamic and nonhemodynamic mechanism of experimental pulmonary edema in rats and the effect of anisodamine and tetramethylpyrazine--electron microscopic observation and measurement of pulmonary arterial, pulmonary arterial wedge and systemic arterial pressure (Part 2). 790 30

Anisodamine (ADM, 654-2, 30 mg/kg) and tetramethylpyrazine (TMP, 120 mg/kg) have shown an apparent preventive effect on pulmonary edema (PE). In this study, the nonhemodynamic mechanism was studied: The dynamic changes of PaO2, O2Sat, PaCO2, and blood pH were measured, and RBC superoxide dismutase (SOD) and plasma and bronchoalveolar lavage (BAL) PGE2 levels were estimated. It was concluded that ADM and TMP exerted inhibitory effects on the hypoxic state. The ability of ADM and TMP to adjust RBC SOD and PGE2 levels may be one of the preventive mechanisms of the drugs.
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PMID:Hemodynamic and nonhemodynamic mechanisms of experimental pulmonary edema in rats and the effects of anisodamine and tetramethylpyrazine--estimation of blood gas analysis, RBC superoxide dismutase and prostaglandin E2 in plasma and bronchoalveolar lavage (Part 3). 803 66