Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034063 (pulmonary edema)
 10,665 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Betaadrenergics are the most important agents in the treatment of premature labour. Often they are used in combination with steroids which promote fetal lung maturation and prevent respiratory distress syndrome in preterm infants. Because PG synthesis inhibitors also reduce uterine contractions they have been used as tocolytics whenever beta adrenergics alone fail. Several cases of pulmonary edema in otherwise healthy pregnant women have been reported following a combined tocolytic treatment with betaadrenergic drugs and PG synthesis inhibitors. The inhibited synthesis and function of renal PGs may be a very important factor contributing to those fatal events. Both, the ADH stimulating effect of beta adrenergics and the inhibition of the negative feed back mechanism of PGs on ADH action by blockade of PG synthesis potentiates renal water retention, thereby increasing the risk of water intoxication. Concerning the effects of maternal tocolytic treatment on the fetus or newborn, there is good evidence that PG inhibitors like aspirin or indomethacin can lead to closure of the ductus Botalli prior to birth and persistent pulmonary hypertension of the newborn. Severe cardiopulmonary adaption disturbances may be the consequence. Routine clinical use of PG synthesis inhibitors in combination with adrenergic stimulants cannot be recommended on the basis of available information.
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PMID:[Risks of simultaneous tocolytic treatment with beta adrenergic and PG inhibiting agents]. 612 12

The water and electrolyte status was studied in 26 children with acute asthma, 8 of whom required hospital admission. Patients were evaluated before therapy, during hospital management, and at least 10 days after symptoms had subsided. Laboratory evaluation included serum electrolytes, BUN, sOsmo, urinalysis, and uOsmo. Data were analyzed for the manifestations of SI-ADH. Mild serum hyposmolarity was noted initially in only two patients and during the hospital stay in one patient for a short time, but none of the patients fulfilled the criteria of SIADH. At the time of presentation at the emergency room, none of the 26 patients had clinical signs of dehydration, yet some degree of hypertonicity seemed to be present in most patients. This study shows that children with acute asthma are ordinarily not at high risk of SIADH and fluid therapy should be included in the management. Nevertheless, because such patients may be at risk of pulmonary edema, vigorous fluid administration should be discouraged, except to correct dehydration.
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PMID:Water and electrolyte status in children with acute asthma. 673 70

This article presents the case of a 52-year-old woman who developed exercise-associated hyponatremia (EAH) complicated by non-cardiogenic pulmonary edema after a marathon run. The condition of EAH is a potentially life-threatening complication of endurance exercise. The main cause seems to be inadequate intake of free water during or following exercise with enduring antidiuresis due to nonosmotic stimulation of ADH secretion. Known risk factors are female gender, slow running pace and lack of weight loss. Emergency therapy is fluid restriction and bolus infusion of 3% NaCl solution to rapidly reduce brain edema.
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PMID:[Hyponatremic encephalopathy with non-cardiogenic pulmonary edema. Development following marathon run]. 2338 23