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Query: UMLS:C0034063 (pulmonary edema)
 10,665 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

High intravenous doses of diatrizoate are known to induce pulmonary edema in the rat. The newer generation of contrast media--nonionics and monovalent dimers--are considered less toxic than diatrizoate. In this study we evaluated the degree of pulmonary edema induced by a high dose (6 g I/kg) of these new agents and found that Ioxaglate produced higher lung weights than Renografin 60 and Iopamidol. Iohexol and Amipaque did not induce a significant degree of edema. The model used in this study demonstrates distinct differences in pulmonary toxicity among these new agents, when given in doses exceedingly higher than given in clinical practice.
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PMID:Contrast media induced pulmonary edema. Comparison of ionic and nonionic agents in an animal model. 651 Dec 65

Monomeric ionic contrast media are known to induce a significant degree of pulmonary edema following intravenous injection of high doses of contrast media in rats. This edema has been shown to be dependent on dose and rate of injection. Metrizamide administered at the same dose causes much less and more transient pulmonary edema than diatrizoate. Although blood osmolalities were significantly and consistently lower following administration of metrizamide compared with diatrizoate, this difference alone does not account for the difference in the degree of pulmonary edema induced by these media.
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PMID:Pulmonary edema induced by contrast medium. A comparative investigation in the rat following high intravenous doses of one ionic (diatrizoate) and non-ionic (metrizamide) contrast medium. 667 May 89

The effects of saline and 3 contrast media, Amipaque, Gastrografin and barium, were evaluated for 24 hours following intratracheal instillation in rabbits. Respiratory rates, serial chest films, and pathologic examination of the lungs demonstrated that Amipaque induced significantly less respiratory distress than the other 2 contrast media whereas inflammatory reactions were comparable for all of the media. Significant pulmonary edema occurred with both Amipaque and Gastrografin but was greater with Gastrografin. Both of these media were cleared from the lung within 24 hours, however barium continued to obstruct bronchi and fill alveolar air spaces. It is concluded that in comparison to Gastrografin and barium, Amipaque is relatively innocuous in the lung.
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PMID:Clinical, radiographic and pathologic effects of Amipaque on rabbit lung. Comparison with barium and Gastrografin. 717 Oct 23