Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0034063 (
pulmonary edema
)
10,665
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To clarify the role of macrophage class A scavenger receptors (
SR-A
, CD204) in oxidative lung injury, we examined lung tissue of
SR-A
deficient (
SR-A
(-/-)) and wild-type (
SR-A
(+/+)) mice in response to hyperoxic treatment. Protein levels of bronchoalveolar lavage fluid (BALF) and
pulmonary oedema
(wet : dry weight ratios) were higher in
SR-A
(-/-) mice than those in
SR-A
(+/+) mice. Cumulative survival was significantly decreased in
SR-A
(-/-) mice. However, there were no differences in BALF macrophage and neutrophil count between the two groups. Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) revealed that messenger RNA (mRNA) levels of the inducible nitric oxide synthase (iNOS) were increased during hyperoxic injury, and this increase was more prominent in
SR-A
(-/-) mice. Expression levels of iNOS in alveolar macrophages after hyperoxia in vivo and in vitro were higher in
SR-A
(-/-) macrophages compared with
SR-A
(+/+) macrophages. Immunohistochemistry using anti-nitrotyrosine antibodies revealed distinctive oxidative stress in the injured lung in both groups, but it was more remarkable in the
SR-A
(-/-) mice. After hyperoxic treatment, pulmonary mRNA levels of tumour necrosis factor-alpha(TNF-alpha) were elevated more rapidly in
SR-A
(-/-) mice than in
SR-A
(+/+) mice. Together these results suggest that
SR-A
expression attenuates hyperoxia-induced lung injury by reducing macrophage activation.
...
PMID:Class A scavenger receptor (CD204) attenuates hyperoxia-induced lung injury by reducing oxidative stress. 1737 Feb 94
