Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034063 (pulmonary edema)
 10,665 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Eight cases of unexpected, unexplained death in young ambulatory epileptics were examined postmortem with special attention to the heart and lungs. Lung weights uniformly exceeded the expected value, with gross evidence of hemorrhagic pulmonary edema. Microscopic examination revealed moderate to severe pulmonary edema with protein-rich fluid as well as alveolar hemorrhage. There was no evidence of recent or old myocardial disease. Although death due to a seizure is usually thought to be almost instantaneous, the neurogenic pulmonary edema exemplified by these cases takes time to develop and may be remediable. The high frequency of absent or non-therapeutic anticonvulsant levels at the time of death in these patients may play a role in a possible centrally mediated adrenergic cause of neurogenic pulmonary edema and ventricular arrhythmia.
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PMID:Neurogenic pulmonary edema in unexpected, unexplained death of epileptic patients. 727 Dec 41

In an English Cocker Spaniel kennel in which the adult population varied between 20 and 30, 11 dogs had evidence of cardiomyopathy over a 5-year period. Three of the affected dogs were found dead, with cardiac enlargement and pulmonary edema found at necropsy. In the other affected dogs, dyspnea and other signs of congestive heart failure developed; 5 of these died. Necropsies were performed on 4 dogs, all of which had cardiac enlargement and pulmonary edema. In 3 dogs, the dyspnea abated with treatment. Four of the 11 affected dogs were less than 5 years old. Chronic valvular disease was discounted because some dogs had no murmurs and, at necropsy, valve leaflets were only slightly thickened. Heart weight ranged from 1.21%-1.56% of body weight.
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PMID:Cardiomyopathy of English cocker spaniels. 727 71

Tumor necrosis factor-alpha (TNF alpha) is a proinflammatory cytokine with negative inotropic effects. Recently, elevated levels of TNF alpha have been identified in patients with advanced heart failure. Although the clinical significance of this finding is unclear at present, there is increasing evidence that this cytokine may play a primary pathophysiologic role in the development and pathogenesis of heart failure in humans. Indeed, many of the clinical hallmarks of heart failure, including left ventricular dysfunction, cardiomyopathy, and pulmonary edema can be explained by the known biological effects of TNF alpha in humans. The present review will summarize recent evidence with regard to the biological role for TNF alpha in the adult mammalian heart, as well as summarize the increasing body of clinical information that implicates this cytokine in the pathophysiology of heart failure.
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PMID:Tumor necrosis factor-alpha and the failing human heart. 748 17

Pheochromocytoma mimicking acute pancreatitis as its initial clinical manifestation is a known, albeit rare, phenomenon. Herein we describe a patient with this occurrence. A striking feature was pronounced hyperamylasemia, almost exclusively of the S-type. Our theory is that the pheochromocytoma caused a catecholamine-induced cardiomyopathy, which contributed to failure of the left ventricle; pulmonary edema and release of S-type amylase from hypoxic lung tissue occurred subsequently.
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PMID:Malignant pheochromocytoma masquerading as acute pancreatitis--a rare but potentially lethal occurrence. 751 73

We revised 7988 laparoscopies over twenty years. Three hundred and ninety three were urgent laparoscopies: 325 patients with acute spontaneous abdomen and 68 acute traumatic abdomen. Emergency laparoscopy is made in patients with, both spontaneous and traumatic acute abdomen, when diagnosis is not made in 8 hours with the usual clinical and imaging methods. Acute diffuse peritonitis was the commonest finding in the first group (21%) and splenic rupture in the traumatic group (34%). There were two severe complications (0.5%): pulmonary oedema in a patient with myocardial disease and a respiratory failure in a old patient, which were resolved. We had two deaths related to laparoscopic diagnosis: massive mesenteric thrombosis and fecal peritonitis. There are few contraindications and tolerance is very good. This study shows a sensitivity of 98%, a specificity of 90%, a predictive positive value greater than 98% and a negative predictive value of 100%. In summary, the present study demonstrates that emergency laparoscopy is a effective diagnostic method in acute abdominal pain of uncertain aetiology.
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PMID:[Emergency laparoscopy. A 20-year experience]. 779 38

A 14-year-old girl had evidence of an acute cardiomyopathy after a minimal overdose of phenylpropanolamine. She had myocardial dysfunction, ventricular dysrhythmia, and secondary pulmonary edema without any associated systemic hypertension. The cardiomyopathy resolved after several days.
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PMID:Cardiomyopathy induced by phenylpropanolamine. 790 55

Two days after an elective Caesarean section, a 30-year-old woman suffered a pulmonary oedema. The diagnosis of cardiomyopathy was obtained with echocardiography, right heart catheterization and a myocardial biopsy. Peripartum cardiomyopathy is defined as a heart failure occurring in the last trimester of pregnancy or up to the third postpartum month and the lack of another etiology. The cause of myocarditis resulting in peripartum cardiomyopathy remains yet unknown. An immunosuppressive therapy can be associated with the treatment of the congestive heart failure.
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PMID:[Pulmonary edema occurring 2 days after elective cesarean section]. 799 50

Eighty-seven cats with histologically confirmed malignant tumors were used in a prospective study to determine the toxicity of mitoxantrone, a dihydroxyquinone derivative of anthracene, which was administered at 21-day intervals at dosages ranging from 2.5 to 6.5 mg/m2 of body surface, IV. Eleven of these cats were treated concurrently with radiation but were evaluated separately. Each cat was evaluated for signs of toxicosis for 3 weeks after each dose was administered or until the cat developed progressive disease, or until the cat's quality of life diminished to an unacceptable level as determined by the owner or attending veterinarian. Although the primary purpose of this study was to determine a clinically useful dosage and to characterize the toxicoses associated with mitoxantrone administration, each cat was monitored for response to treatment. Forty-nine cats had been refractory to 1 or more treatment modalities prior to inclusion in this study. The most common signs of toxicosis after treatment with mitoxantrone were vomiting, anorexia, diarrhea, lethargy, sepsis secondary to myelosuppression, and seizures. Two cats died of complications that may have been attributed to mitoxantrone: 1 of cardiomyopathy and the other of pulmonary edema of an undetermined cause. Older cats were more likely to develop signs of toxicosis after the third or fourth mitoxantrone treatment than younger cats (P < or = 0.05). Cats with signs of toxicosis during the 21-day interval after administration of the first dose of mitoxantrone were significantly (P < or = 0.05) more likely to develop signs of toxicosis during the 21-day interval between the second and third doses of mitoxantrone.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Toxicoses and efficacy associated with administration of mitoxantrone to cats with malignant tumors. 832 Jan 52

We encountered a case of pheochromocytoma which was characterized by the sudden onset of acute renal failure and pulmonary edema. Acute renal failure was rapidly improved after surgical removal of the tumor. This patient was also found to have a hypertrophied, dilated and hypokinetic left ventricle as assessed by echocardiography. Two years after tumor resection, cardiac size and function were normalized. This shows that a catecholamine-induced cardiomyopathy is reversible.
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PMID:A case of pheochromocytoma complicated with acute renal failure and cardiomyopathy. 843 46

beta-Adrenergic receptor agonist tocolysis has been reported to cause noncardiogenic pulmonary edema. We report an association between chronic terbutaline therapy and cardiomyopathy in peripartum women. Among 15 gravidas who had peripartum heart failure, 4 had received prolonged terbutaline tocolysis. Although those four patients had completely normalized ventricular function, only 7 of the 11 others recovered. We suggest that gravidas receiving long-term beta-sympathomimetic tocolysis undergo close evaluation of cardiac function.
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PMID:Peripartum heart failure associated with prolonged tocolytic therapy. 843 16


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