Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034063 (pulmonary edema)
 10,665 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A smoke inhalation model was created in 22 adult male sheep with pine smoke inhalation through an endotracheal tube for 6 min. Arterial blood gases, HbCO, HbO2 and pulmonary compliance (Cdyn) were monitored, and the morphology of the tracheobronchial tree and pulmonary parenchyma were studied by light and electron microscopy. Severe carbon monoxide poisoning with fatal levels of HbCO (greater than 50 percent) was found at the end of smoke inhalation. Acute respiratory distress, progressive hypoxemia, decreased pulmonary compliance and increased P(A-a)O2 and Qs/QT occurred after injury. Tracheobronchial blockade by pseudomembrane cast, pulmonary edema, atelectasis and necrosis of pulmonary epithelia were demonstrated pathologically. The mechanisms of CO poisoning and ARF are discussed.
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PMID:The pathophysiology of carbon monoxide poisoning and acute respiratory failure in a sheep model with smoke inhalation injury. 230 76

The occurrence of pulmonary toxic reaction due to vinblastine sulfate alone or in combination with drugs other than mitomycin is not known. Acute respiratory distress is a rare phenomenon in patients receiving both chemotherapeutic agents. Two cases of fatal acute respiratory failure due to pulmonary edema occurred in patients receiving vinblastine-mitomycin for non-small-cell carcinoma of the lung. In view of the unpredictability of the reaction, observation of patients receiving this combination therapy is recommended.
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PMID:Fatal acute respiratory failure after vinblastine-mitomycin therapy in lung carcinoma. 403 52

Acute respiratory distress (ARD) in two nonimmune adults with imported mixed and vivax malarial infections with low and resolving parasite load is described. Malarial pulmonary edema exacerbated by hypoalbuminemia and fluid redistribution without overload occurred in the latter patient. ARD led to mortality in one of the two. ARD should be promptly recognized and managed.
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PMID:Respiratory distress in nonimmune adults with imported malaria. 1559 26

Acute respiratory distress is a common cause of emergency admission to hospital. Clinicians may face difficulties in terms of diagnosis (etiology), especially in older subjects, often presenting with multiple medical conditions. The Brain Natriuretic Peptid (BNP) assay is an interesting new diagnostic tool in this context, since it differentiates pulmonary dyspnea from pulmonary edema in these patients. However, this laboratory examination should be used with discretion and analyzed according to the clinical setting to avoid possible false positive results. Symptomatic treatment of respiratory distress (oxygen therapy and/or respiratory support) is essential. Except from some clearly identified medical conditions (for instance cardiogenic pulmonary edema in hypertensive subjects, acute asthma attacks or tension pneumothorax), the effect of a specific treatment is often limited, at least in terms of immediate outcome.
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PMID:[Acute respiratory distress]. 1673 6

Acute respiratory distress syndrome (ARDS) is characterized by sudden onset of respiratory distress, infiltrates on radiographs consistent with pulmonary oedema, hypoxaemia and increased work in breathing. Infiltrates on radiographs are bilateral, but may be patchy or diffuse and fluffy or dense. It is associated with absence of left heart failure and a PaO2/FiO2 ratio of < or =200. Ethylene vinyl alcohol copolymer dissolved in dimethyl sulfoxide (DMSO), which was approved by the US FDA in July 2005, is used as an embolic agent for cerebral arteriovenous malformation (AVM). It is a biocompatible liquid polymer that precipitates and solidifies on contact with blood, thus forming a soft and spongy embolus. We report a case of ARDS following therapeutic embolization with ethylene vinyl alcohol copolymer for cerebral AVM under general anaesthesia. Experienced perioperative physicians adopted standard anaesthetic technique and monitoring for this procedure. Acute respiratory distress and hypoxaemia developed in the patient following extubation of the trachea. Infiltrates seen on postprocedural chest radiographs were consistent with pulmonary oedema. DMSO, the solvent for the ethylene vinyl alcohol copolymer, is excreted via the lungs after administration and we postulate that DMSO was the possible cause of ARDS in this patient. Monitoring of haemodynamic parameters (invasive blood pressure, electrocardiography) and ventilatory parameters (ETCO2, SpO2, airway pressure monitoring) are important in the recognition of this possible event. One should be vigilant and anticipate this complication following therapeutic embolization with ethylene vinyl alcohol polymer for the treatment of cerebral AVM.
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PMID:Severe pulmonary oedema following therapeutic embolization with Onyx for cerebral arteriovenous malformation. 1817 30