Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034063 (pulmonary edema)
 10,665 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The dynamics of left ventricular contraction was studied in 107 patients with cardiac fibrillation 1 and 6-8 days after restoration of sinus rhythm by electroimpulsive therapy. It has been found that contraction of the left ventricle improves markedly 24 hours after the sinus rhythm is restored and practically does not change by the 6th -8th day after that. On the grounds of such dynamics of left ventricular contraction it is concluded that it is quite sufficient to observe complete bedrest after successful defibrillation for 24 hours, since the risk of normalization embolisms and pulmonary edema sharply diminishes beginning 24 hours after the sinus rhythm has been restored. It is shown that the dynamics of myocardial contration following restoration of the sinus rhythm cannot serve for the prognostication of the remote results of electroimpulsive therapy.
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PMID:[Dynamics of myocardial contraction in patients with auricular fibrillation after restoration of sinus rhythm by means of electric countershock]. 67 69

The Epstein-Barr virus nuclear antigen-leader protein (EBNA-LP) is required for high efficiency B lymphocyte growth transformation by the virus. To test the potential contribution of EBNA-LP to tumorigenesis in vivo, we produced transgenic mice carrying an EBNA-LP cDNA construct, using the widely expressed metallothionein promoter. Expression of EBNA-LP was detected in liver, kidney, heart, lung and spleen. There were no apparent oncogenic consequences of EBNA-LP expression. Unexpectedly however, at ages ranging from about 4 months to over a year, transgenic mice developed symptoms of congestive heart failure, including left ventricular dilatation, right ventricular hypertrophy, left atrial thrombosis, pulmonary oedema and hydrothorax. Fibrillation was not apparent in the electrocardiograph; however a reduction in T-wave amplitude suggested that the development of an abnormality of ventricular repolarization may precede the manifestation of overt symptoms. The highly predictable development of dilated heart failure in these transgenic mice suggests they may be a useful model for the pathophysiological changes associated with human dilated cardiomyopathy.
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PMID:Dilated heart failure in transgenic mice expressing the Epstein-Barr virus nuclear antigen-leader protein. 839 79