Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034063 (pulmonary edema)
 10,665 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Leiomyosarcoma of the esophagus is a rare neoplasm. We reported a very rare case of esophageal leiomyosarcoma associated with pulmonary edema by the compression of the left atrium. A 67-year-old man was admitted with a 3-month history of chest pain, exertional dyspnea and dysphagia. Chest X-ray computed tomography showed posterior mediastinal tumor. Esophageogastroscopy and fiberoptic bronchofiberscopy showed no direct invasion of the tumor. By echocardiography, the left atrium was found to be compressed by the tumor and pulmonary hypertension (58/25 mmHg) and increased pulmonary wedge pressure (25 mmHg) was present. Open biopsy specimen demonstrated elongated cells suggestive of sarcoma. At autopsy, the tumor was confirmed to be leiomyosarcoma and to be originated from the lower esophagus.
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PMID:[Leiomyosarcoma of the esophagus associated with pulmonary edema by the compression of the left atrium]. 175 20

Uterine leiomyosarcoma is an uncommon malignant neoplasm that frequently metastasizes through the bloodstream to distant organs such as the lung, bone, and brain. We report on and discuss a patient who had sudden onset of acute heart failure with pulmonary edema and bilateral pleural effusions, resulting from a high-grade uterine leiomyosarcoma metastatic to the left atrium. Surgical removal of the tumor terminated the acute heart failure and pulmonary edema. Other unusual features of this case include the metastatic leiomyosarcoma to the left atrium with expression of acute heart failure and the pulmonary tumor lesion obscured by the shadows of pleural effusion, pulmonary edema, and the breast.
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PMID:Acute heart failure as manifestation of metastatic uterine leiomyosarcoma to the heart and lung. 1498 39

In this paper, the authors report the case of a 28-year-old man with pulmonary vein leiomyosarcoma presenting subacute respiratory distress. Thoracic computed tomography and transoesophagal ultrasonographic examination of the heart suggested the diagnosis of a heart tumour revealed by the obstruction of the mitral valve and pulmonary oedema. Emergency cardiac surgery revealed the mass to be a leiomyosarcoma, probably extending from the right inferior pulmonary vein and extending into the left atrium. The clinical evolution was complicated because of a sudden local relapse. The patient underwent a second cardiac intervention involving lower right lobectomy followed by adjuvant chemotherapy with an ifosfamide-adriamycin combination. This treatment failed to control the disease and a third cardiac intervention was necessary with second-line gemcitabine-paclitaxel adjuvant chemotherapy. Further recurrences were observed with metastases first in the scalp and then in the spine and adrenal glands leading to the death of the patient 2 years after the diagnosis.
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PMID:[Pulmonary vein leiomyosarcoma extending into the left atrium]. 2108 28

In this case report we present the history of a patient admitted with recurrent pulmonary edema. Transesophageal echocardiography showed a tumour in the left atrium, occluding the ostium of the mitral valve and mimicking intermittent mitral stenosis. Cardiac surgery followed by pathological examination revealed that the tumour was a leiomyosarcoma. Images from the echocardiography as well as the pathological findings are shown and discussed. The present case report illustrates that atrial tumors comprise also sarcomas, suggesting the use of careful, rapid diagnostic procedures and treatment to prevent dissemination of malignancy.
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PMID:Cardiac leiomyosarcoma, a case report. 2369 44

Pulmonary metastases are a rare but aggressive and life-threatening complication of leiomyosarcoma. We discuss a case of a 48-year-old woman with stage 4b leiomyosarcoma who presented with dyspnea and hemodynamic instability secondary to a large lung metastasis with massive pleural effusion. This particular subset of patients is vulnerable to re-expansion pulmonary edema in a disease with poor survival rates.
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PMID:Pleural Effusion with Mediastinal and Hemidiaphragm Mass Effect: A Case Report. 3161

Gemcitabine and docetaxel combination chemotherapy is the standard of care for patients with unresectable recurrent or metastatic leiomyosarcoma of the uterus. Although they are generally well-tolerated agents, they can also cause severe and life-threatening pulmonary toxicities. Here, we describe a case of grade 4 pneumonitis due to gemcitabine and docetaxel in a 74-year-old woman with recurrent, metastatic uterine leiomyosarcoma. Despite early recognition of chemotherapy-induced lung injury and early administration of corticosteroid, she developed noncardiogenic pulmonary edema, diffuse alveolar hemorrhage, and acute respiratory distress syndrome. She required multiple intubations and a tracheostomy. Physicians should not only be aware of gemcitabine and docetaxel's potential to cause life-threatening pulmonary injuries but also recognize the variability in clinical presentations and treatment responses, the radiographic findings of these lung toxicities, and the need for early corticosteroid therapy in these cases.
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PMID:Grade 4 Pneumonitis in a Patient Treated with a Combination of Gemcitabine and Docetaxel for Recurrent Leiomyosarcoma of the Uterus. 3208 16